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Microbes weaponizing secondary metabolites to make rivals vulnerable to phage attack 🧪🦠 www.nature.com/articles/s41...

Streptomyces secretes a siderophore that sensitizes competitor bacteria to phage infection - Nature MicrobiologyA secondary metabolite sensitizes competitor Bacillus subtilis to a wide panel of lytic phages by sequestering iron and preventing the activation of Spo0A.www.nature.com

🏆 Institut Pasteur Canetti Prize 2025 awarded to Céline Loot for her innovative contributions to infectious disease research. This annual Institut Pasteur prize (€15K) honors scientific excellence, funded by the Canetti family legacy. Congratulations Céline 👏

#mycrosky #synbio www.biorxiv.org/content/10.1...

Adapting CRISPR-associated transposons for rapid and high-throughput reverse geneticsCRISPR-associated transposons (CAST) use guide RNAs to direct their transposition and are being harnessed as tools for programmable genome engineering across diverse bacterial species. However, CAST s...www.biorxiv.org

Lost Science is a new NYT series of accounts from scientists who have lost their jobs or funding. You can send your story to the Times here www.nytimes.com/2025/10/08/c...

Have you wondered if some E. clones are so successful because of their plasmids? www.biorxiv.org/content/10.1... A combination of bioinf and lab work showed that some plasmids have coexisted for centuries, and that a specific colicin gene is able to kill other clones paving their way for success!

How do spontaneous mutations arise? In this latest #GENETICS review, Susan Lovett and @thalia.bsky.social provide a detailed overview of bacterial genetics experiments instrumental in understanding how genomes change. buff.ly/CXJnTqn

www.biorxiv.org/content/10.1... #microsky

Pseudomonas aeruginosa lasR is a keystone gene in polymicrobial culturesThe airways of people with cystic fibrosis (CF) are often co-infected by Pseudomonas aeruginosa and a variety of other co-habiting microbes; the infections are polymicrobial. P. aeruginosa isolates fr...www.biorxiv.org

www.science.org/doi/10.1126/... #microsky #microbiome DGRs FTW

Targeted protein evolution in the gut microbiome by diversity-generating retroelementsDiversity-generating retroelements (DGRs) accelerate evolution by rapidly diversifying variable proteins. The human gastrointestinal microbiota harbors the greatest density of DGRs known in nature, su...www.science.org

Quite an interesting protein search AI model combining sequence, structure, and function text - faster and more accurate than similarity searches. Who has tried it🤩🙌? Only a few secs to search bacterial TFs and integrases #microsky 🧬🧪 www.nature.com/articles/s41...

A trimodal protein language model enables advanced protein searches - Nature BiotechnologyA protein foundation model represents protein sequence, structure and function.www.nature.com

www.nature.com/articles/s41... #microsky #genomics #phagesky #phage defense

De novo discovery of conserved gene clusters in microbial genomes with Spacedust - Nature MethodsThis work presents Spacedust, a tool for de novo identification of conserved gene clusters from metagenomic data.www.nature.com

#ResultatScientifique🔎| Des scientifiques ont révélé comment le plasmide pOXA-48 rend les bactéries ultra-résistantes aux antibiotiques 🦠 🤝 @cnrs.fr @mmsb-lyon.bsky.social @cnrs-rhoneauvergne.bsky.social ✍️ @sbigot.bsky.social 📕 @natcomms.nature.com | buff.ly/u3Cy4Db

1. Kevin Gross and I just posted a new science-of-science preprint. This one explores the looming peer review crisis. As many of you know, it's becoming significantly more difficult for journal editors to find scholars willing to serve as peer reviewers for submitted manuscripts.

Will anyone review this paper? Screening, sorting, and the feedback cycles that imperil peer reviewScholarly publishing relies on peer review to identify the best science. Yet finding willing and qualified reviewers to evaluate manuscripts has become an increasingly challenging task, possibly even ...arxiv.org

A bacterial host factor confines phage localization for excluding the infected compartment through cell division @cp-cellreports.bsky.social from Sigal Ben-Yehuda www.sciencedirect.com/science/arti...

A bacterial host factor confines phage localization for excluding the infected compartment through cell divisionViruses frequently induce the formation of specialized subcellular compartments to facilitate their replication and assembly. Here, we describe a “hos…www.sciencedirect.com

Today in the journal Science: BioEmu from Microsoft Research AI for Science. This generative deep learning method emulates protein equilibrium ensembles – key for understanding protein function at scale. www.science.org/doi/10.1126/...

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@cnrsecologie.bsky.social regrette profondément l'adoption de cette loi à la vision court-termiste & ses conséquences graves sur l’environnement, qui méprise santé & bien-être de la population & le rôle des espèces sauvages dans la prod. agricole. La communauté scientifique n'a pas été entendue.

🚨🚨New paper out in @natcomms.nature.com!! Come for the first large-scale analysis of plasmid copy number across species, stay for one of the most intriguing results of my lab: universal scaling laws in plasmid biology! 📈🧬 👉 www.nature.com/articles/s41...

Universal rules govern plasmid copy number - Nature CommunicationsPlasmids exhibit a broad range of sizes and copies per cell, and these two parameters appear to be negatively correlated. Here, Ramiro-Martínez et al. analyse the copy number of thousands of diverse b...www.nature.com

Harnessing Small RNAs as Synthetic Post-transcriptional Regulators in Bacteria pubs.acs.org/doi/10.1021/...

Harnessing Small RNAs as Synthetic Post-transcriptional Regulators in BacteriaBacteria can respond to environmental changes by expressing small RNAs (sRNAs), which regulate mRNAs by complementary base-pairing. This regulatory mechanism allows bacteria to rapidly adapt their proteome. In recent years, sRNAs have gained attention as blueprints for synthetic regulators allowing control over user-defined targets. Multiple aspects need to be considered for efficient application of these versatile, on-demand, and easy-to-use tools. Advances in computational prediction and bioengineering concepts are the dawn of systematic synthetic sRNA biology. We provide an overview of sRNAs and alternative post-transcriptional regulators, highlight the requirements for successful regulation, and provide guidelines for design, construction, and sRNA application.pubs.acs.org

Researchers uncover a new class of retropepsin-like proteases in P. aeruginosa that are required for biofilm formation & bacterial survival under stress conditions, including antibiotic exposure, making them appealing therapeutic targets. #mBio: asm.social/2sq

Check out these amazing lipid-monolayer-trapping oligomeric OMPs published by @lalouxlab.bsky.social and Lovering Labs. The BAM complex in these bugs must be wild! www.nature.com/articles/s41...

A porin-like protein used by bacterial predators defines a wider lipid-trapping superfamily - Nature CommunicationsThis study reveals that an outer membrane protein from the predator Bdellovibrio bacteriovorus forms a pentameric assembly that traps a lipid monolayer within. This allows the discovery of two superfa...www.nature.com

Where is the money going? In the case of for-profit publishers it's very clear: Your open access fees fund corporate profit margins. Profit margins for large academic publishers can far exceed those of household names like Amazon and Apple. chart source: bit.ly/4leULKi #scipub #academicsky