Nature Microbiology publishes the latest research and commentary in all areas of microbiology. https://www.nature.com/nmicrobiol/
Out Now! A microbial PPARadigm for gut protection #MicroSky
A microbial PPARadigm for gut protectionNature Microbiology, Published online: 30 July 2026; doi:10.1038/s41564-026-02423-2Two independent studies converge on the nuclear receptor PPARα as a key node in gut microbiome communication, highlighting it as a potential therapeutic target in intestinal diseases.go.nature.comOut Now! Microbiota-derived 10-hydroxystearic acid activates PPARα to restore gut epithelial barrier integrity and enhance anti-retroviral therapy #MicroSky
Microbiota-derived 10-hydroxystearic acid activates PPARα to restore gut epithelial barrier integrity and enhance anti-retroviral therapyNature Microbiology, Published online: 30 July 2026; doi:10.1038/s41564-026-02433-0Lactiplantibacillus plantarum-derived fatty-acid metabolite, 10-hydroxystearic acid, interacts directly with PPARα to alter histone crotonylation and the transcriptional landscape which leads to gut barrier functional repair and enhanced viral suppression in non-human primate models when combined with anti-retroviral therapy.go.nature.comOut Now! Combined phage therapy and faecal microbiota transplantation to treat recurrent urinary tract infection: a case series #MicroSky
Combined phage therapy and faecal microbiota transplantation to treat recurrent urinary tract infection: a case seriesNature Microbiology, Published online: 30 July 2026; doi:10.1038/s41564-026-02409-0In a small case series, combined phage therapy and faecal microbiota transplantation was safe and led to sustained reductions in recurrence, severity and antibiotic use in women with recurrent urinary tract infections, even without complete eradication of Escherichia coli.go.nature.comOut Now! Cell-autonomous immunity as an integrated immune network against bacterial and viral pathogens #MicroSky
Cell-autonomous immunity as an integrated immune network against bacterial and viral pathogensNature Microbiology, Published online: 30 July 2026; doi:10.1038/s41564-026-02428-xThis Review summarizes the current knowledge about the cell-intrinsic factors that act against pathogenic bacteria and viruses and the immune evasion strategies that pathogens have to counteract cell-autonomous immunity.go.nature.comOut Now! Phage hijacks host phosphorothioate DNA modification machinery to circumvent bacterial Ssp defences #MicroSky
Phage hijacks host phosphorothioate DNA modification machinery to circumvent bacterial Ssp defencesNature Microbiology, Published online: 29 July 2026; doi:10.1038/s41564-026-02387-3The phage-encoded protein PptA enables its DNA to masquerade as the host and evade cleavage, providing a potential foundation for engineering therapeutic phages that could bypass this widespread defence system.go.nature.comOut Now! Gut microbiota restricts intestinal lipid uptake via modulation of bile phosphatidylcholine metabolism in mice #MicroSky
Gut microbiota restricts intestinal lipid uptake via modulation of bile phosphatidylcholine metabolism in miceNature Microbiology, Published online: 29 July 2026; doi:10.1038/s41564-026-02434-zLipidomics and proteomics in mice colonized with variable gut microbiota reveal an important role of gut microbes in restricting lipid uptake via triggering Myd88 signalling and the degradation of phosphatidylcholine in bile.go.nature.com
Delighted to have this collaborative work out in @natmicrobiol.nature.com on how A. muciniphila deploys its sulfatases, both their localisation and substrate specificity, to metabolise colonic mucin www.nature.com/articles/s41... #glycotime.
Unique adaptations in sulfatases underpin colonic mucin degradation by Akkermansia muciniphila - Nature MicrobiologyStructural and biochemical follow-up of a serendipitous discovery reveals that Akkermansia muciniphila carbohydrate sulfatases are uniquely adapted to digest colonic mucins in collaboration with other...www.nature.comOut Now! Unique adaptations in sulfatases underpin colonic mucin degradation by Akkermansia muciniphila #MicroSky
Unique adaptations in sulfatases underpin colonic mucin degradation by Akkermansia muciniphilaNature Microbiology, Published online: 27 July 2026; doi:10.1038/s41564-026-02424-1Structural and biochemical follow-up of a serendipitous discovery reveals that Akkermansia muciniphila carbohydrate sulfatases are uniquely adapted to digest colonic mucins in collaboration with other members of gut microbiota.go.nature.com
Dear microbiome enthusiasts: I'm excited to be moving my lab to New York University this fall (& the NYU Institute for Engineering Health); with joint-appointment @isbscience.org I'm hiring a postdoc @ NYU to look at diet-driven evolution in the gut: apply.interfolio.com/189980 Please share! 🦠🤓
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio apply.interfolio.comOut Now! Antiviral GHP-88310 blocks contact-mediated and airborne transmission in a ferret model of measles-like disease #MicroSky
Antiviral GHP-88310 blocks contact-mediated and airborne transmission in a ferret model of measles-like diseaseNature Microbiology, Published online: 24 July 2026; doi:10.1038/s41564-026-02419-yAntiviral candidate GHP-88310 provides therapeutic benefit against measles-like disease and protects against productive direct-contact and airborne viral transmission when used for pre- and post-exposure prophylaxis.go.nature.comOut Now! Ebola virus persistence and the hidden cost of immune privilege #MicroSky
Ebola virus persistence and the hidden cost of immune privilegeNature Microbiology, Published online: 23 July 2026; doi:10.1038/s41564-026-02432-1Human brain organoids reveal how Ebola virus establishes persistent infection within the immune-privileged environment of the central nervous system.go.nature.comOut Now! Within-patient gene transfer between transiently and chronically infecting bacteria causes extreme antibiotic resistance during lung infections #MicroSky
Within-patient gene transfer between transiently and chronically infecting bacteria causes extreme antibiotic resistance during lung infectionsNature Microbiology, Published online: 23 July 2026; doi:10.1038/s41564-026-02414-3Antibiotic resistance gene acquisition by Pseudomonas aeruginosa and Achromobacter from transiently infecting bacteria drives rapid and extreme resistance to tobramycin during chronic lung infection within patients.go.nature.com
Delighted to share our last Kleb work. From developing a platform to asses in real time bugs effect on vessels to nail down the role of the T6SS and the CPS including in vvo work. Superb collaboration and hard work of PhD student @safimicro.bsky.social
Nature MicrobiologyOut Now! Klebsiella pneumoniae inhibits vasodilation through capsule and T6SS-dependent pathways #MicroSky
Out Now! Clarifying objectives to strengthen wastewater-based AMR surveillance #MicroSky
Clarifying objectives to strengthen wastewater-based AMR surveillanceNature Microbiology, Published online: 21 July 2026; doi:10.1038/s41564-026-02429-wClarifying objectives to strengthen wastewater-based AMR surveillancego.nature.comOut Now! Molecular and cellular insights into the parasitic infection of bloom-forming marine diatoms by Pirsonia diadema #MicroSky
Molecular and cellular insights into the parasitic infection of bloom-forming marine diatoms by Pirsonia diademaNature Microbiology, Published online: 21 July 2026; doi:10.1038/s41564-026-02421-4Ultrastructure expansion microscopy, live-cell imaging and time-resolved dual RNA sequencing reveal the infection dynamics of a microparasite, providing insights into how Pirsonia diadema shapes marine trophic networks.go.nature.comOut Now! Groundwater microbial communities across the terrestrial subsurface #MicroSky
Groundwater microbial communities across the terrestrial subsurfaceNature Microbiology, Published online: 21 July 2026; doi:10.1038/s41564-026-02427-yHere the authors propose the concept of ‘microbial frugality’ as an evolutionary outcome of life under the chronic energy limitation of the subsurface and a way to understand Earth’s hidden biogeochemical engine.go.nature.comOut Now! Klebsiella pneumoniae inhibits vasodilation through capsule and T6SS-dependent pathways #MicroSky
Klebsiella pneumoniae inhibits vasodilation through capsule and T6SS-dependent pathwaysNature Microbiology, Published online: 21 July 2026; doi:10.1038/s41564-026-02425-0Vasodilation is inhibited by Klebsiella pneumonia through a multipronged approach involving type VI secretion system activity and the VgrG4 effector, plus capsule, to limit eNOS-dependent and endothelial hyperpolarization routes to vasodilation.go.nature.comOut Now! Mapping in-cell protein contact sites reveals hijacking of paraspeckles during influenza A virus infection #MicroSky
Mapping in-cell protein contact sites reveals hijacking of paraspeckles during influenza A virus infectionNature Microbiology, Published online: 20 July 2026; doi:10.1038/s41564-026-02416-1In-cell cross-linking mass spectrometry maps protein contacts in influenza-infected human cells, revealing how the virus hijacks host membrane-trafficking factors and dismantles nuclear paraspeckles to enhance replication.go.nature.comOut Now! All-trans retinoic acid suppresses systemic inflammation induced by severe fever with thrombocytopenia syndrome virus in mice #MicroSky
All-trans retinoic acid suppresses systemic inflammation induced by severe fever with thrombocytopenia syndrome virus in miceNature Microbiology, Published online: 20 July 2026; doi:10.1038/s41564-026-02411-6Depletion of the vitamin A metabolite all-trans retinoic acid (ATRA) in patients infected with severe fever with thrombocytopenia syndrome virus correlates with severe inflammation. In mice, ATRA supplementation reduces IL-6 levels and hyperinflammation.go.nature.com