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A long-standing mystery in cholesterol biology: why is ER cholesterol sensing so switch-like rather than gradual? Our answer: cholesteryl ester phase separation in the ER membrane, which converts small lipid changes into a cooperative transcriptional response. www.biorxiv.org/content/10.6...

ER cholesteryl ester phase separation underlies switch-like cholesterol sensingCellular lipid homeostasis requires mechanisms that detect subtle changes in lipid abundance and trigger rapid, coordinated responses. The INSIG/SCAP/SREBP2 pathway provides a central feedback system ...www.biorxiv.org

How does an adenovirus transform from an immature particle into an infectious virus? See our new preprint for a closer look at how protease activity orchestrates structural changes that enable adenovirus maturation and infectivity. www.biorxiv.org/content/10.6...

🚀 My first Cryo-EM structures are OUT on the PDB! 🎉Super excited about this milestone as PhD, it’s been a journey, and I’m grateful to finally have these as my first Cryo-EM structures! 🙌 🔁Thank you for sharing!❤️ Read @daaninthelab.bsky.social et. al.: www.science.org/doi/10.1126/... ⬇️ 2nd video

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I'm not sure folks have realized just how crazy the second half of 2026 and 2027 will be for global temperatures – on the back of a record-smashing El Niño event. Here is my latest estimate of where both years will end up compared to global temperatures since 1850.

Take a look at our new paper on the structure of the EHD2 that, upon oligomerization, forms rings that remodel the plasma membrane and form caveolae. Beautiful work by Elena, Vasya @vasiliimikirtumov.bsky.social, Jeff & Oliver Dumke's team; take a look: www.nature.com/articles/s41...

Ebola may have been spreading for months in the DRC before anyone recognized it. A new reconstruction suggests the outbreak was already widespread in the gold-mining town of Mongbwalu by January. It wasn’t officially declared until 15 May. Why did no-one raise the alarm? My story for @science.org 🧪

EXCLUSIVE: Congo’s Ebola epidemic started at least 4 months before it was detectedA remote mining town gripped by fear saw hundreds of suspected cases before the government declared an outbreak, report sayswww.science.org

We are excited to share two preprints reporting a mosquito-specific receptor for chikungunya virus and other alphaviruses! 🤩 www.biorxiv.org/content/10.6... www.biorxiv.org/content/10.6... @harvardmicro.bsky.social @harvardvirology.bsky.social @hhmi-science.bsky.social

How do poxviruses initiate infection after getting into the cytoplasm? With Tom Calcraft, @miguel-virus-cells.bsky.social & Peter Rosenthal, @crick.ac.uk we solved the structure of the vaccinia virus portal that mediates viral assembly and early mRNA and subsequent genome release. rdcu.be/fwGTn

In situ structure of the poxvirus portal complexNature - Cryo-electron tomography uncovers the structure of a conserved hexameric ‘portal complex’ that spans the core wall in vaccinia virus, and shows how it is associated with viral...rdcu.be

my god www.reuters.com/world/africa...

US government map of Africa mislabels every country at global conferenceA U.S. government ​map of Africa mislabeled every country during a State Department presentation at a global conference ‌in Brazil this week, causing a stir among attendees who took screenshots and po...www.reuters.com

One month left to apply (deadline August 31st)! 👇 #Virology #AcademicJobs #FacultyJobs #FacultyPosition #TenureTrack #GroupLeader

Wie weit sind wir wirklich im Kampf gegen HIV? Ein aktueller Blick auf den Stand der Forschung und auf die Herausforderungen, die noch vor uns liegen.👇 www.tagesschau.de/wissen/gesun... #HIV #AIDS (HMB)

So steht es um die weltweite Aids-BekämpfungIn Rio de Janeiro treffen sich von heute an Tausende Menschen zur internationalen Aids-Konferenz - dem größten und wichtigsten Forum zum Thema HIV und Aids. Wie steht es um die Forschung? Ein Überblic...www.tagesschau.de

Small new user-requested feature in 2.0 beta 5 - Surface Morphometrics can export obj in arbitrary voxel coordinates to make tools like Surforama easier to use.

Rand Paul swiftly moved from wet markets to "natural immunity". Rambling. Quoting Martin Kulldorff. Time to post one of my favorite xkcd drawings xkcd.com/2557/ ▫️42/ #faucihearing

Electron counting enables cryo-electron ptychography for near-atomic-resolution cryo-electron microscopy https://www.biorxiv.org/content/10.64898/2026.07.25.736262v1

Lipids build the membranes of all cells, but identifying their precise functions is extremely challenging. Here’s our attempt to change that: How to find and understand lipid-protein interactions, by Katelyn Cook & company. www.biorxiv.org/content/10.6...

Congratulations to Ellen Zhong, Princeton University, for receiving the 2026 K.H. Kuo Award for Outstanding Young Scientist in Structural Biology www.bsc.org.cn/KuoSymposium...

Congratulations to Chris Russo, MRC Laboratory of Molecular Biology, for receiving the 2026 K.H. Kuo Award for Distinguished Scientist in Biological Electron Microscopy www.bsc.org.cn/KuoSymposium...

Breaking news: Shanghai Jiao Tong University School of Medicine will launch a “comprehensive investigation” into the previously undisclosed death last year of a 6-year-old girl who had received an experimental gene therapy from one of its scientists. Learn more: https://scim.ag/4yJXPoU

A question: does anyone know about communities or groups for scientists who are committed to writing without the use of LLMs / genAI?

This story is now published in @natplants.nature.com ! 🎉🎩 Check out the final article here: nature.com/articles/s41477-026-02361-1 Very similar to the original bioRxiv preprint, with the addition of some cool polysome analysis (in the supplementals)! Thanks and congrats to everyone involved! 🙏

Chloroplast-encoded small subunit extensions reshape the Chlamydomonas chlororibosome - Nature PlantsUsing in situ cryo-electron tomography, researchers found a unique ‘arm’ domain on the small subunit of Chlamydomonas chlororibosomes. This discovery suggests that chlororibosome structure is more evo...www.nature.com