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Профиль

Jun Ishigohoka

Профиль Vively

Evolutionary biologist. Phenotypic noise < bird migration genomics Tübingen < Plön < Kiel < Sapporo < Tokyo https://junishigohoka.github.io/

⟳ Репост от Jun Ishigohoka

Very cool pair of papers demonstrating little link between amount of additive genetic variation and amount of nucleotide variation within species: journals.plos.org/plosbiology/... www.pnas.org/doi/10.1073/...

Levels of additive genetic variation vary substantially between speciesAdaptive potential determines how populations respond to environmental change. This study compiles evolvability estimates from over 170 multicellular species, revealing substantial variation across th...journals.plos.org
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⟳ Репост от Jun Ishigohoka

New paper out in Phil. Trans. B! We set out to understand how seasonal migration evolves by combining a common garden experiment and scATAC-seq of the hypothalamus in ancestral migratory and derived resident populations of the Eurasian blackcap. 1/n

Differential epigenetic regulation underlies evolutionary transition of seasonal migrationAbstract. Seasonal migratory animals can evolve residency through adaptation. The threshold model of quantitative genetics predicts that residency evolvesdoi.org
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⟳ Репост от Jun Ishigohoka

Genotype-by-environment-by-environment (GxExE) interactions have the potential to shape adaptation in response to multiple stressors https://www.biorxiv.org/content/10.64898/2026.07.21.739626v1

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⟳ Репост от Jun Ishigohoka

Researchers have discovered a contagious cancer in catfish – just the fourth example of tumour cells that spread naturally from one animal to another go.nature.com/4fsoLR3

Rare contagious cancer discovered in wild catfishTransmissible tumours have been found in only a few types of animal, but there might be many more out there.go.nature.com
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⟳ Репост от Jun Ishigohoka

Neural correlates of seed-eating in songbirds royalsocietypublishing.org/rspb/article... Our new paper showing that songbirds that dehusk seeds with the beak and tongue have an enlarged trigeminal nucleus in the brainstem, particularly the part where the tongue is represented.

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⟳ Репост от Jun Ishigohoka

Our latest paper on how transcription factor binding sites for global regulators can evolve in bacteria is now published in eLife! Mutation by mutation, we are uncovering the regulatory landscapes of bacteria. elifesciences.org/digests/1037...

Step by mutational stepNew bacterial regulatory interactions can evolve more readily than previously appreciated, providing new insights into the evolution of gene regulation.elifesciences.org
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⟳ Репост от Jun Ishigohoka

New #microsky#AMR Perspective paper with @penamiller.bsky.social rdcu.be/fqBJo ANTIBIOTIC RESISTANCE (IE MIC) AND TOLERANCE ARE NOT BACTERIAL TRAITS! Please read on if you want an explanation for this provocative claim.

Beyond resistance and tolerance: rethinking evolutionary responses to antibiotics from the perspective of individual bacterial cellsNature Communications - Beyond resistance and tolerance: rethinking evolutionary responses to antibiotics from the perspective of individual bacterial cellsrdcu.be
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⟳ Репост от Jun Ishigohoka

📢 happy to share our new paper in @molecology.bsky.social Common chiffchaff subspecies diverge in the same migration-related region as willow warblers (see thread): onlinelibrary.wiley.com/doi/10.1111/...

Common Chiffchaffs (<fi>Phylloscopus collybita</fi>) Diverge in a Genomic Region Associated With Migration Differences in Willow Warblers (<fi>Phylloscopus trochilus</fi>)Despite technological advances in both tracking and sequencing technologies, finding the genetic mechanisms behind migratory traits remains a challenge. Recent studies have shown that migratory direc...onlinelibrary.wiley.com
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⟳ Репост от Jun Ishigohoka

#ERGAReads | 🐦‍⬛ 🦜 🪶 Insights into Convergent Evolution From Studying Amino Acid Patterns in Independent Lineages of Birds academic.oup.com/gbe/article/... #genomes #birds #convergentevolution #birdgenomics @genomebiolevol.bsky.social @erichjarvis.bsky.social

Insights into Convergent Evolution From Studying Amino Acid Patterns in Independent Lineages of BirdsAbstract. Vocal learning, the ability to imitate sounds, is a complex convergent trait crucial for spoken language and observed in a few independent lineagacademic.oup.com
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⟳ Репост от Jun Ishigohoka

MIT Professor Susumu Tonegawa, renowned molecular biologist and Nobel laureate, dies at 86 news.mit.edu/2026/mit-pro... #neuroscience

MIT Professor Susumu Tonegawa, renowned molecular biologist and Nobel laureate, dies at 86Susumu Tonegawa, a renowned MIT professor of biology and neuroscience and a Nobel laureate, has died at the age of 86. His discovery of how the immune system generates many different antibodies earned...news.mit.edu
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⟳ Репост от Jun Ishigohoka

I am very happy to share that our article, "Splicing of a core circadian clock gene regulates seasonal adaptations by a winter gating mechanism," is now available in Science Advances. 🎊 (1/4) www.science.org/doi/10.1126/...

Splicing of a core circadian clock gene regulates seasonal adaptations by a winter gating mechanismThe circadian clock integrates photoperiodic and temperature cues by RNA splicing to promote seasonal plasticity.www.science.org
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⟳ Репост от Jun Ishigohoka

New preprint! We sequenced 175 'Alalā (Hawaiian crow) genomes to understand why >50% of eggs fail to hatch in a species recovered from just 9 individuals. What we found was a both exciting and surprising. www.biorxiv.org/content/10.6...

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⟳ Репост от Jun Ishigohoka

How do aerodynamic constraints and evolutionary pressures shape the diversity of flight in true flies? By integrating wing shape, wing motion and #aerodynamics, this study uncovers similarities as well as striking divergences in flight performance. 🧪 #AcademicSky #evolution plos.io/4b4LMbJ

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⟳ Репост от Jun Ishigohoka

Immune cells exist as continuous clouds, not discrete categories. In this Perspective, @tal-shay.bsky.social &co reframe immune identity through systems biology, and propose that immunotherapies should aim at dynamics of the cell cloud. 🧪 #AcademicSky #immunology plos.io/4oWuoLG

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⟳ Репост от Jun Ishigohoka

Seafaring turtles navigate by moving in one direction at a time during ocean migrations, even when doing so causes them to go off course for a while, new research suggests. Learn more in #ScienceAdvances: https://scim.ag/4xNAwtR

Records of compass heading for long-distance ocean migrators show mid-ocean reorientationRecords of compass headings show that migrating green turtles only occasionally reorient during ocean crossings.scim.ag
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⟳ Репост от Jun Ishigohoka

The lab is at #SMBE2026! Come see @junishigohoka.bsky.social talk on Wednesday in the "Fitness Landscapes" symposium @3:50pm. Jun will talk about our theoretical and experimental efforts to understand the implications of *probabilistic* GP maps for evolution (in contrast w *deterministic* GP maps).

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⟳ Репост от Jun Ishigohoka

Paper alert!🧬🐦💻 Divergent selection is the textbook explanation for narrow inversion clines. Our blackcap inversion cline doesn't fit: it is wide, and the inversion is always the rarer arrangement. We show that negative frequency-dependent selection shifting between populations underlies this!

Shifting Balancing Selection Underlies an Inversion Cline in Eurasian BlackcapWe investigated what factor contributes to a cline of a chromosomal inversion of the Eurasian blackcap, which differs from typical inversion clines maintained by divergent selection. Using a simulati...onlinelibrary.wiley.com
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⟳ Репост от Jun Ishigohoka

A fundamental study of individual variation and contribution of learning to behavioural individuality. Conclusions are supported by compelling, rigorous analysis across a number of experiments in thousands of individuals across genotypes and conditions.

Learning is a fundamental source of individualityAltmetric provides a collated score for online attention across various platforms and media.See more detailsbuff.ly
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⟳ Репост от Jun Ishigohoka

awesome work by @junishigohoka.bsky.social highlighting the underappreciated role of shifting balancing selection. jun used demography inference, pogen simulation under our blackcap demography, and ABC to (i) identify the type of balancing selection and (ii) estimate its spatially varying parameters

Jun Ishigohoka

Paper alert!🧬🐦💻 Divergent selection is the textbook explanation for narrow inversion clines. Our blackcap inversion cline doesn't fit: it is wide, and the inversion is always the rarer arrangement. We show that negative frequency-dependent selection shifting between populations underlies this!

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