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Профиль

Jun Ishigohoka

Профиль Vively

Evolutionary biologist. Phenotypic noise < bird migration genomics Tübingen < Plön < Kiel < Sapporo < Tokyo https://junishigohoka.github.io/

academic.oup.com/mbe/article/...

The life history of recessive deleterious alleles as seen through the eyes of a honey bee (Apis mellifera)Abstract. Deleterious mutations arise continually in natural populations, yet their full life histories—from origin to elimination—are rarely observed direacademic.oup.com
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www.nature.com/articles/s41...

Theoretical morphospace reveals mixed optimisation of the avian wing planform for flight style - Nature CommunicationsHere, the authors examine bird wing planform shape and functional performance using theoretical morphospace and phylomorphospace. They find that, in a sample of 1138 extant bird taxa, planform shape i...www.nature.com
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New paper out in Phil. Trans. B! We set out to understand how seasonal migration evolves by combining a common garden experiment and scATAC-seq of the hypothalamus in ancestral migratory and derived resident populations of the Eurasian blackcap. 1/n

Differential epigenetic regulation underlies evolutionary transition of seasonal migrationAbstract. Seasonal migratory animals can evolve residency through adaptation. The threshold model of quantitative genetics predicts that residency evolvesdoi.org
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www.science.org/doi/10.1126/...

CD4+ T cells reactive to Epstein-Barr virus late lytic antigens are enriched in individuals with multiple sclerosisCD4+ T cells in MS preferentially recognize EBV viral particles rather than latent antigens, and responses are reduced by B cell–targeting therapies.www.science.org
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Glad to see my former study species blackcap appear in the final plenary by @mexpositoalonso.bsky.social #smbe2026

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#SMBE2026 I will talk about **evolutionary roles of non-genetic variation**. If you care about expression noise, developmental instability, microenv. variance, or selection experiments (or if you don't believe in genetic determinism), come join me in S20 "mapping fitness landscapes" (17:30, Pjerrot)

Society for Molecular Biology and Evolution

#SMBE2026 S20: Mapping fitness landscapes with mechanistic models, machine learning and experiments 🗓️ Wed Jul 1, 3:50pm 🔗 smbe2026.org/programme

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www.nature.com/articles/s41...

Distinct genetic architecture in the tails of complex traits - NatureGenome-wide analyses in multiancestry and European cohorts show that in complex traits, rare alleles have disproportionately large effects at the tails of the phenotypic spectrum compared with common ...www.nature.com
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Paper alert!🧬🐦💻 Divergent selection is the textbook explanation for narrow inversion clines. Our blackcap inversion cline doesn't fit: it is wide, and the inversion is always the rarer arrangement. We show that negative frequency-dependent selection shifting between populations underlies this!

Shifting Balancing Selection Underlies an Inversion Cline in Eurasian BlackcapWe investigated what factor contributes to a cline of a chromosomal inversion of the Eurasian blackcap, which differs from typical inversion clines maintained by divergent selection. Using a simulati...onlinelibrary.wiley.com
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logistic regression according to BioRender

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Homing pigeon navigation relies on superparamagnetic macrophages under overcast conditions | Science www.science.org/doi/10.1126/...

Homing pigeon navigation relies on superparamagnetic macrophages under overcast conditionsBirds use a variety of navigational strategies, including the geomagnetic field, especially when other cues are not available, such as under overcast or nocturnal conditions. Magnetite particles in th...www.science.org
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www.nature.com/articles/s41...

Specific expansion of motor cortical projections in a singing mouse - NatureHigh-throughput barcoded neuroanatomy&nbsp;of two closely related&nbsp;rodent&nbsp;species with&nbsp;divergent vocalizations reveals differences in long-range projection motifs in the brain that may s...www.nature.com
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elifesciences.org/articles/969...

Heterogeneity of Sonic Hedgehog response dynamics and fate specification in single neural progenitorsComparing signaling response profiles and fate outcomes in single cells reveals logic and limits of signal interpretation.elifesciences.org
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www.pnas.org/doi/10.1073/...

Coalescence and translation: A language model for population genetics | PNASProbabilistic models such as the sequentially Markovian coalescent have long provided a powerful framework for population genetic inference, enabli...www.pnas.org
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www.sciencedirect.com/science/arti...

Strain variation identifies a neural substrate for behavioral evolution in DrosophilaSexual selection acts on heritable differences within species, driving the parallel diversification of signal production in one sex and behavioral res…www.sciencedirect.com
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