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Neurons don't just fire more for important sounds, their activity becomes more precisely timed and rhythmic Representations of spatial saliency in auditory cortex are selectively organized through temporal coordination www.biorxiv.org/content/10.6... #neuroscience

Representations of spatial saliency in auditory cortex are selectively organized through temporal coordinationSelective processing of behaviorally relevant sounds in complex environments requires dynamic modulation of auditory representations. Here, we show that behaviorally relevant sound locations selective...www.biorxiv.org

New results: Anesthesia may disrupt consciousness by weakening how brain regions influence one another. This is uneven, which may help explain bursts of activity seen under anesthesia. Disruption of interareal control during propofol anesthesia www.biorxiv.org/content/10.6... #neuroscience

Brain waves can act like holograms/radio signals. Traveling waves can carry spike-timing info, interfere like light waves in holography, and get processed in frequency stages. doi.org/10.3389/fnco... #neuroscience

Frontiers | A proposal for realizing cognitive functions using traveling waves, phase-locked and synchronized patterns, holography, neural mixing, and single sideband communicationsWaves are fundamental. In our view, waves in the brain may constitute and drive organized neural activity patterns on individual neural and population levels...doi.org

Lab & life Composing a science life with music www.nature.com/articles/s41... #neuroscience

Are brain rhythms a steady hum or a brief buzz? Both. Alpha and beta activity are relatively sustained, helping maintain ongoing brain state, supporting its role in top-down control. Universal rhythmic architecture uncovers two modes of neural dynamics www.nature.com/articles/s41... #neuroscience

Universal rhythmic architecture uncovers two modes of neural dynamics - Nature CommunicationsBrain oscillations are traditionally regarded as sustained rhythms. Here, the authors show that there are both high and low-rhythmicity bands, characterised by brief bursts, which can signal responses...www.nature.com

Dinner with these geeks. Neuroblox.ai Board of Directors.

Most neurons seem to be generalists, not specialists. Cortical circuits prioritize diversity over categorical structure. Rarely categorical, highly separable representations along the cortical hierarchy www.nature.com/articles/s41... #neuroscience www.newscientist.com/article/2581...

Rarely categorical, highly separable representations along the cortical hierarchy - NatureCortical circuits prioritize diversity over categorical structure, supporting a computational regime geared towards high-dimensional, highly separable neural representations.www.nature.com

Short-term synaptic plasticity improves network function, addressing limitations of models that rely only on persistent activity. Short-term plasticity-based working memory spiking model is resilient to synaptic heterogeneity doi.org/10.1103/zcmm... #neuroscience

Temporary synaptic plasticity holds information in the background, ready for use. If it works well and is simple enough for modern computers, 4 billion years of evolution likely found it first. Working Memory as Programmable Fast Weight Computation doi.org/10.64898/202... #neuroscience

Working Memory as Programmable Fast Weight ComputationWorking memory (WM) stores information after sensory input disappears and later retrieves it in a task-relevant format, but the mechanism unifying storage and retrieval remains unclear. Here we combine neural geometry analyses of macaque dorsolateral prefrontal cortex activity during a visuospatial delayed-match-to-sample task with computational modeling to test whether WM can be implemented as recurrent fast-weight computation. We found that the relational geometry of remembered locations was strongly expressed during sample presentation, degraded during the early delay, and reemerged before requirement in a partially distinct mnemonic subspace. A recurrent fast-weight programmer model, which implements a form of dynamic fast-weight memory closely related to linear Transformer computation, reproduced these latent-to-mnemonic dynamics. Direct inspection and perturbation of the model revealed that neural activity writes stimulus information into rapidly modifiable synaptic states, synaptic dynamics organize this latent memory over time, and recurrent readout queries the evolving state to generate task-relevant activity. These findings provide a unified account of WM storage and retrieval and suggest that biological WM and Transformer family architectures share an algorithmic principle of programmable temporary memory. ### Competing Interest Statement The authors have declared no competing interest. National Natural Science Foundation, T2488101doi.org

The brain uses a fixed set of building blocks and flexibly recombines them, allowing adapting to new tasks. Learning stabilizes temporal activity but not neuronal selectivity in prefrontal cortex doi.org/10.64898/202... #neuroscience

Learning stabilizes temporal activity but not neuronal selectivity in prefrontal cortexIntelligent behavior requires neural representations to change with new demands while preserving learned structure. The prefrontal cortex is central to this ability, but the mechanisms are unclear. Here, we tracked medial prefrontal neurons for months as mice learned an association task with successive rule switches. Learning progressively stabilized when individual neurons were active during a trial, but not what task variables they responded to. Neurons repeatedly gained, lost, or changed selectivity even after their activity profile had stabilized. We developed Sparse Tensor Component Analysis to show that, rather than reflecting random drift, dynamic single-neuron selectivity arose through rule-dependent recombination of a fixed set of task representations. Thus, learning established a stable temporal scaffold in the prefrontal cortex within which neurons participated flexibly in different representations. ### Competing Interest Statement The authors have declared no competing interest. European Research Council, https://ror.org/0472cxd90, 758032 Deutsche Forschungsgemeinschaft, https://ror.org/018mejw64, JA 1999/6-1, JA 1999/8-1 ONE Munich Strategy Forum, N/Adoi.org

Unilateral Striatal Deep Brain Stimulation Improves Cognitive Control doi.org/10.1523/JNEU... #neuroscience

Unilateral Striatal Deep Brain Stimulation Improves Cognitive ControlDeep brain stimulation (DBS) of the ventral capsule/ventral striatum (VCVS) can treat obsessive-compulsive disorder (OCD) and other psychiatric conditions. Yet, optimizing its clinical efficacy is a m...doi.org

“We humans tend to overestimate how special we are” www.nytimes.com/2026/07/21/s...

Monkeys Understand Shapes in Almost the Same Way as Humans (Gift Article)Our geometric intuition, long considered something that sets us apart, seems to be shared with other primates.www.nytimes.com

NY Times obit for Susumu Tonegawa www.nytimes.com/2026/07/21/s...

Susumu Tonegawa Dies at 86; Nobel Laureate Showed How Antibodies Fight Infectionwww.nytimes.com

"alpha band activity functions as a malleable “sampling rate” for speech processing" Alpha rhythms in the left auditory cortex set the speed limit for speech comprehension doi.org/10.1073/pnas... #neuroscience

The primate claustrum as a hub for precision weighting of prediction errors across the cortical hierarchy. journals.plos.org/plosbiology/... #neuroscience

The primate claustrum as a hub for precision weighting of prediction errors across the cortical hierarchyUnderstanding how signals are exchanged across the cerebral cortex is a central challenge for theories of perception and cognition. This Essay puts forward a roadmap for investigating cortical network...journals.plos.org

Huzzah! MIT names Emery N. Brown an "Institute Professor," its highest faculty honor picower.mit.edu/news/mit-nam... #neuroscience

MIT names Emery N. Brown an "Institute Professor," its highest faculty honorBrown, a renowned neuroscientist, anesthesiologist and statistician, has made numerous seminal contributions to basic science and clinical care alike. He joins two other professors in earning the hono...picower.mit.edu

New release: Neuroblox 0.9. Introducing the Neuroblox GUI: a visual environment for building, simulating, and analyzing biophysically grounded brain circuits. github.com/Neuroblox/Ne... #neuroscience

New Results! A biologically grounded simulation can predict how a drug changes brain circuits and even uncover new biomarkers without being trained on the data first. Mechanistic simulation identifies predictive dose-dependent biomarkers of propofol anesthesia doi.org/10.64898/202... #neuroscience

Mechanistic simulation identifies predictive dose-dependent biomarkers of propofol anesthesiaUnderstanding how receptor-level pharmacological modulation reorganizes large-scale brain circuits remains a central challenge in neuropharmacology. We introduce a multiscale mechanistic model with ex...doi.org

Adaptive, closed-loop systems may be the future of the BCIs that will restore or improve function. The emerging field of cognitive brain–computer interfaces www.cell.com/trends/cogni... #neuroscience

The emerging field of cognitive brain–computer interfacesBrain–computer interfaces (BCIs) have achieved transformative success in restoring movement and communication. However, extending these approaches to decoding or recovery of cognitive function, such a...www.cell.com

The prefrontal cortex across scales: laminar architecture, white-matter constraints, and distributed control in cognition link.springer.com/article/10.1... #neuroscience

The prefrontal cortex across scales: laminar architecture, white-matter constraints, and distributed control in cognition - Brain Structure and FunctionThe prefrontal cortex (PFC) is often treated as the anatomical seat of executive control. We defend a distributed but structurally constrained account. The PFC is not an exclusive executive locus; it ...link.springer.com