Профиль

David Bikard

Профиль Vively

Bacterial Immunity and Synthetic Biology enthusiast. Head of Lab at Institut Pasteur. Co-Founder of Eligo Bioscience.

1,8 тыс. подписчиков1,2 тыс. подписок127 публикаций
⟳ Репост от David Bikard
Nature Microbiology

Out Now! Phage hijacks host phosphorothioate DNA modification machinery to circumvent bacterial Ssp defences #MicroSky

Phage hijacks host phosphorothioate DNA modification machinery to circumvent bacterial Ssp defencesNature Microbiology, Published online: 29 July 2026; doi:10.1038/s41564-026-02387-3The phage-encoded protein PptA enables its DNA to masquerade as the host and evade cleavage, providing a potential foundation for engineering therapeutic phages that could bypass this widespread defence system.go.nature.com
⟳ Репост от David Bikard
Prof Jenny Rohn

“Resistance did not arise from mutation accumulation or strain displacement. Instead, it occurred because plasmid-borne resistance genes were transferred to the previously sensitive pathogens inside patients’ lungs”. Cool (sobering) study #AMR #MicroSky #IDSKy #CysticFibrosis

Nature Microbiology

Out Now! Within-patient gene transfer between transiently and chronically infecting bacteria causes extreme antibiotic resistance during lung infections #MicroSky

⟳ Репост от David Bikard
Spyros Lytras

Come work on exciting AI for biology projects in Paris!! 🇫🇷 Details and application below, deadline sept 1st!

Antigen Evolution & Design Lab

🚨 JOB ALERT🚨 We are very excited to be hiring the lab's ✨very first postdoc✨! Work on new AI technologies for decoding antigen protein evolution in a fresh research environment, at the heart of Paris 🇫🇷 Details & link to apply: research.pasteur.fr/en/job/postd... Deadline: Sep 1st

⟳ Репост от David Bikard
François Rousset

Systematic structural analyses reveal the function of viral genes + unveil conserved immune evasion strategies shared across distant viruses. Amazing work 🤯

Jason Nomburg

Happy to share the first preprint out of the Nomburg lab! Many aspects of cellular immunity are shared across the tree of life. Here, we show that some of these conserved aspects of cellular immunity are mirrored by conserved effectors of immune antagonism. Thread below! 1/15

⟳ Репост от David Bikard
Aude Bernheim

Out @cp-cellhostmicrobe.bsky.social, natural products meet bacterial immunity! We used genomics to identify lanthivirins: a family of >2,000 lanthipeptide BGCs that protect Actinobacteria against phages. Led by @hshomar.bsky.social & @mariegllm.bsky.social www.sciencedirect.com/science/arti...

A family of lanthipeptides with anti-phage functionBacteria produce natural products to adapt to their environments, with phage interactions as major ecological and evolutionary drivers. While some nat…www.sciencedirect.com
⟳ Репост от David Bikard
Osterman Ilya

🚨 We're hiring! My new lab at EMBL Hamburg is looking for a Research Technician. I'm looking for someone excited by phages, metabolism, enzymes, structural biology and bacterial immunity—if you know the right person, please share this post!🧵⬇️ Apply here: embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Research Technician (Osterman Group – Metabolism-driven immunity)EMBL Hamburg / CSSB The European Molecular Biology Laboratory (EMBL) is Europe’s flagship life sciences organization, with more than 110 independent research groups across Heidelberg, Hamburg, Grenobl...embl.wd103.myworkdayjobs.com
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⟳ Репост от David Bikard
artemisaev

Thrilled to share! We present the structure of a prototypical P2 OLD and reveal that its tRNAse activity is triggered by ssDNA hairpins in phage origins or unresolved termini in RecBCD-deficient cells. Great team effort with Wang, Bikard & Nudler labs. www.biorxiv.org/content/10.6...

OLD sentinel: an abortive tRNase surveys phage replication and DNA defects in RecBCD-compromised cellsOLD, an abortive immunity protein from prophage P2, consists of an ABC ATPase sensor and a TO-PRIM nuclease effector - a core architecture shared by a large protein family, including components of ant...www.biorxiv.org
⟳ Репост от David Bikard
Sorek Lab

Our paper out in Science today: The Metis defense system senses molecular byproducts released when a phage degrades the bacterial genome, and then prevents replication of the phage in the infected cell Congratulations @ostermanilya.bsky.social and co-authors!

Bacteria sense virus-induced genome degradation via methylated mononucleotidesPhages often degrade the genome of their bacterial host to individual nucleotides. Here we describe Metis, a bacterial defense system that directly senses phage-mediated host genome degradation. Metis...www.science.orgOsterman Ilya

Excited to share that our Metis story is now published in Science! 🎉 Bacteria can sense phage-induced degradation of their genome and activate immunity. Many thanks to everyone who contributed to this work. 📄 www.science.org/doi/10.1126/... More details in my earlier thread 🧵⬇️

⟳ Репост от David Bikard
Zeynep Baharoglu

Functional divergence and conservation in the QueC protein family (PF06508): from tRNA modification to anti-phage defense 🦠 portlandpress.com/biochemj/art...

Functional divergence and conservation in the QueC protein family (PF06508): from tRNA modification to anti-phage defenseAbstract. The QueC protein family (PF06508) is best known for its role in the biosynthesis of 7-deazaguanine derivatives, including the tRNA modification queuosine and the DNA base 7-cyano-7-deazaguan...portlandpress.com
⟳ Репост от David Bikard
Tung Le

Finally published. Many thanks to a wonderful collaborative team and scientific platforms!!! And thanks to editors and reviewers for enthusiasm and a great review. www.nature.com/articles/s41...

A bacterial CARD–NLR-like immune system controls the release of gene transfer agents - Nature MicrobiologyAn immunity-like system functions as a lysis control hub to promote gene transfer agent particle release from host bacterial cells, suggesting that bacterial immune systems may be co-opted to promote ...www.nature.comTung Le

1/ Excited to share our latest work on gene transfer agents (GTAs) in Caulobacter crescentus, led by Emma Banks in collaboration with Pavol Bardy and Mai Nguyen from York!!! See a brief thread below. shorturl.at/o6S1w

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