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1/4 Excited to share our new preprint on phage genome editing: Targeted DNA nicking enables efficient, single-step and counterselection-free editing of bacteriophage genomes Preprint: lnkd.in/dv4g5kW6

🚀 Excited to share that I’ve been awarded an EMBO Installation Grant to establish my research group at the EMBL Partnership Institute, Vilnius University Life Sciences Center! The grant provides €50,000/year for 5 years to build an internationally competitive lab and advance genome editing research.

🚀 New publication alert! 🚀 We just published in @natbiotech.nature.com: 👉 Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotes doi.org/10.1038/s415...

Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotes - Nature BiotechnologyAppend editing of ADP-ribosyl to thymine is used for precise modifications in bacteria and eukaryotes.doi.org

🚀 Join the Patinios Lab at the VU LSC - EMBL Partnership Institute for Genome Editing Technologies! We are looking for a Postdoctoral Researcher to join our growing team! 🔎

Excited to see our SIBR work out in Trends in Biotechnology :) doi.org/10.1016/j.ti... This is the first study I have coordinated from start to finish, and it brings me immense satisfaction to see it published. For a brilliant description of the tech check this: www.linkedin.com/feed/update/...

SIBR2.0 is now out in a preprint!! doi.org/10.1101/2024...

Streamlined and efficient genome editing in Cupriavidus necator H16 using an optimised SIBR-Cas systemCupriavidus necator H16 is a promising microbial platform strain for CO2 valorisation. While C. necator is amenable to genome editing, existing tools are often inefficient or rely on lengthy protocols...doi.org

How about a new genome editing tool?? #Append Editing, #ADPr-TAE, #Homologous recombination, #Base mutagenesis. doi.org/10.1101/2024... Thread: 🧵

Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotesBase editors create precise genomic edits by directing nucleobase deamination or removal without inducing double-stranded DNA breaks. However, a vast chemical space of other DNA modifications remains ...doi.org