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Online now: The liver-secreted protein FGL1 restrains a subset of innate-like B cell responses via the receptor TACI

The liver-secreted protein FGL1 restrains a subset of innate-like B cell responses via the receptor TACINegative regulatory ligands have been underexplored for B cells. Su et al. identify fibrinogen-like protein 1 (FGL1) as a new inhibitory ligand for a transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI) on a subset of B cells, exploring the biochemistry, function, and potential application of the FGL1/TACI interaction in lupus-like autoimmune disease.dlvr.it

In partnership with the @alleninstitute.org we’re delighted to be hosting the @cellpressevents.bsky.social Neuro-immune axis: Charting the periphery #CPSNeuroimmune27 at the New York Academy of Medicine, USA, Sept 13–15, 2027. http://dlvr.it/TTm7rT

Online now: Bile acids in cancer: From metabolism to immunomodulation

Bile acids in cancer: From metabolism to immunomodulationFang and Schneider review how bile acids connect host metabolism, microbial ecology, and tumor immunity. They present a spatial and cell-type-aware framework for bile acid immunomodulation and discuss therapeutic opportunities to remodel bile acid-immune circuits in cancer.dlvr.it

Online now: TCR origin and specificity to environmental or self-antigens on distinct antigen-presenting cells determine peripheral Treg cell differentiation

TCR origin and specificity to environmental or self-antigens on distinct antigen-presenting cells determine peripheral Treg cell differentiationUsing CRISPR-based TCR editing, Chi et al. systematically compare gut TCRs recognizing dietary, microbial, and self-antigens to define the principles that govern peripheral Treg cell differentiation. They find that TCR identity encodes pTreg cell generation, phenotype, and antigen-presenting cell dependence, establishing TCR specificity as a primary organizer of peripheral immune tolerance.dlvr.it

Online now: Environmentally induced cell stiffening shapes metastatic site selection by tuning the immune vulnerability of cancer cells

Environmentally induced cell stiffening shapes metastatic site selection by tuning the immune vulnerability of cancer cellsAdherent cells mimic the mechanical properties of their surroundings, becoming stiffer in more rigid environments and softer in more compliant ones. Elbanna et al. find that this environmentally induced stiffening response shapes metastatic site distribution by preferentially sensitizing cancer cells to cytotoxic lymphocytes in stiff contexts, such as the bone.dlvr.it

Online now: Disease-associated microglia adopt stage-specific phenotypes that regulate T cell fate and immunity in glioma

Disease-associated microglia adopt stage-specific phenotypes that regulate T cell fate and immunity in gliomaHow brain-resident microglia regulate T cell immunity during glioma progression remains unclear. Qian et al. show that disease-associated microglia (DAMs) are not fixed suppressors but instead evolve with tumor stage. DAMs transition from antigen-presenting and checkpoint-regulatory states to T cell-clearing programs, shaping local T cell responses in the brain.dlvr.it

Online now: Purine and pyrimidine-based bacterial cyclic dinucleotides egress the phagosome and activate the innate immune sensor STING

Purine and pyrimidine-based bacterial cyclic dinucleotides egress the phagosome and activate the innate immune sensor STINGInnate immune recognition of bacteria is thought to center on cell-surface or endosomal pattern recognition receptors such as TLRs. Ragland et al. identify an intraphagosomal cyclic dinucleotide (CDN)-host transporter-STING axis, wherein cytoplasmic STING acts as a common sensor of diverse bacteria, capable of detecting a broad array of CDN species, including pyrimidine-based CDNs.dlvr.it

Online now: The transcription factor BACH1 couples chromatin priming and repression to enable macrophage plasticity and adaptation

The transcription factor BACH1 couples chromatin priming and repression to enable macrophage plasticity and adaptationMacrophage plasticity and function involve precise regulation of transcriptional programs. Tzerpos et al. find that the transcription factor BACH1 establishes early chromatin accessibility while maintaining transcriptionally repressive states in naive macrophages before activation. This dual activity—termed pioneer repression—regulates macrophage adaptation and inflammatory kinetics in vivo.dlvr.it

Online now: Autophagy maintains high endothelial venule identity and function during inflammation

Autophagy maintains high endothelial venule identity and function during inflammationHigh endothelial venules (HEVs) facilitate lymphocyte entry into lymph nodes by displaying peripheral node addressin (PNAd), yet how PNAd is regulated remains poorly understood. Jacobs et al. reveal that autophagy preserves HEV identity and function by sustaining PNAd production. Loss of autophagy impairs lymphocyte recruitment, while targeting this pathway dampens inflammation in mouse models of psoriasis.dlvr.it

Online now: Activation of the auricular vagus nerve reflex suppresses airway inflammation

Activation of the auricular vagus nerve reflex suppresses airway inflammationBioelectronic technologies are being deployed to treat many inflammatory conditions using transcutaneous auricular nerve stimulation. Shibuya et al. employ viral tracing, chemogenetics, and optogenetics to unveil a sensory skin-lung vagal reflex that suppresses allergic airway inflammation. They identify the neuropeptide CGRPβ as a key mediator and provide a rationale for transcutaneous bioelectronic neuromodulation in asthma.dlvr.it