Online now: Purine and pyrimidine-based bacterial cyclic dinucleotides egress the phagosome and activate the innate immune sensor STING
Purine and pyrimidine-based bacterial cyclic dinucleotides egress the phagosome and activate the innate immune sensor STINGInnate immune recognition of bacteria is thought to center on cell-surface or endosomal pattern recognition receptors such as TLRs. Ragland et al. identify an intraphagosomal cyclic dinucleotide (CDN)-host transporter-STING axis, wherein cytoplasmic STING acts as a common sensor of diverse bacteria, capable of detecting a broad array of CDN species, including pyrimidine-based CDNs.dlvr.it