Brain endothelial cells orchestrate a neuroprotective antiviral state in the CNS in response to peripheral viral pattern sensingWest Nile virus and other neurotrophic arboviruses can cause life-threatening encephalitis. Lewy et al. identify a cross-organ immune circuit where viral pattern sensing in the skin potently counteracts viral encephalitis. Mechanistically, the establishment of this neuroprotective state depends on systemic type I interferon, which is sensed and relayed into the brain by endothelial cells to mitigate encephalitis.dlvr.it
Brain endothelial cells orchestrate a neuroprotective antiviral state in the CNS in response to peripheral viral pattern sensingWest Nile virus and other neurotrophic arboviruses can cause life-threatening encephalitis. Lewy et al. identify a cross-organ immune circuit where viral pattern sensing in the skin potently counteracts viral encephalitis. Mechanistically, the establishment of this neuroprotective state depends on systemic type I interferon, which is sensed and relayed into the brain by endothelial cells to mitigate encephalitis.dlvr.it