Danger fuels immune escapeExtracellular ATP (eATP) is an immunogenic danger signal. In this issue of Immunity, Hu et al. report that in the tumor microenvironment, eATP signals through the receptor P2RY2 on cancer cells, triggering the COX-PGE2 pathway and thereby immune suppression and immunotherapy resistance. These findings identify eATP as the upstream signal driving PGE2 expression, with therapeutic implications.dlvr.it
Danger fuels immune escapeExtracellular ATP (eATP) is an immunogenic danger signal. In this issue of Immunity, Hu et al. report that in the tumor microenvironment, eATP signals through the receptor P2RY2 on cancer cells, triggering the COX-PGE2 pathway and thereby immune suppression and immunotherapy resistance. These findings identify eATP as the upstream signal driving PGE2 expression, with therapeutic implications.dlvr.it