Профиль

The Lambrechts Lab

Профиль Vively

Research unit @pasteur.fr investigating arbovirus transmission by mosquitoes.

⟳ Репост от The Lambrechts Lab

Come work on exciting AI for biology projects in Paris!! 🇫🇷 Details and application below, deadline sept 1st!

Antigen Evolution & Design Lab

🚨 JOB ALERT🚨 We are very excited to be hiring the lab's ✨very first postdoc✨! Work on new AI technologies for decoding antigen protein evolution in a fresh research environment, at the heart of Paris 🇫🇷 Details & link to apply: research.pasteur.fr/en/job/postd... Deadline: Sep 1st

⟳ Репост от The Lambrechts Lab

Flavivirus infectivity in mosquitoes like Aedes aegypti is shaped by mosquito-capsid interactions, shedding light on species-specific vector traits. PMID:41639463, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10100-x #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Mosquito–capsid interactions contribute to flavivirus vector specificity | NatureMultiple mosquito species serve as competent vectors to carry and transmit numerous flaviviruses1,2. Several long-standing scientific questions remain to be answered, including identification of the fundamental factors that facilitate flavivirus infectivity in mosquitoes and the genetic basis that contributes to the naturally occurring interspecies specificity of mosquitoes to flaviviruses3–8, such as Aedes aegypti mosquitoes to dengue virus (DENV). Here we report that circulating mature virions are inactivated by the acidity of mosquito haemolymph; thus, extracellular vesicles carrying replication-competent viral nucleocapsids serve as the predominant means of intercellular viral dissemination. Mechanistically, mosquito valosin-containing protein (VCP) binds to the viral capsid, thereby allowing the incorporation of nucleocapsids into extracellular vesicles. The capsid of a flavivirus (such as DENV) selectively binds to the VCP of its natural vector (Ae. aegypti), but not to that of adoi.org
⟳ Репост от The Lambrechts Lab

At last! Please check out our study now published @natcomms.nature.com on the #virus small #RNAs profiles across Aedes aegypti #mosquitoes from labs and around the world: www.nature.com/articles/s41...

Small RNA genomics of Aedes aegypti mosquitoes discovers infectious viruses that trigger an RNA interference response - Nature CommunicationsThis study is a small RNA genomics survey from global Aedes aegypti mosquito samples, and detected replicating viruses. This study then isolated several mosquito viruses into cell cultures to show tha...www.nature.com

🚨 We're hiring! A #postdoc position is available @lambrechtslab.bsky.social @pasteur.fr ➡️ Come join our team to investigate the #genomic variations underlying the adaptive potential and vectorial capacity of Aedes aegypti #mosquitoes 🦟 More details at this link: research.pasteur.fr/b/1Cov

Postdoctoral position in mosquito population genomics at Institut Pasteur in Paris - ResearchThe Insect-Virus Interactions Unit is looking for a postdoctoral researcher to investigate the genomic variations underlying a mosquito’s capacity to transmit human arboviruses. Description Our resear...research.pasteur.fr

🚨 A #postdoc position is available @lambrechtslab.bsky.social @pasteur.fr ➡️ Come join our team to investigate the #genomic variations underlying the adaptive potential and vectorial capacity of Aedes aegypti #mosquitoes 🦟 More details at this link: research.pasteur.fr/b/1Cov

Postdoctoral position in mosquito population genomics at Institut Pasteur in Paris - ResearchThe Insect-Virus Interactions Unit is looking for a postdoctoral researcher to investigate the genomic variations underlying a mosquito’s capacity to transmit human arboviruses. Description Our resear...research.pasteur.fr
⟳ Репост от The Lambrechts Lab

Two postdoc positions for a number of exciting epidemic modelling projects opening in my Unit at @pasteur.fr in beautiful Paris. Deadline for applications: 13th April. More details at the following link: research.pasteur.fr/job/two-post...

Two postdoctoral positions in epidemic modelling - ResearchJob description We are recruiting 2 postdocs to contribute to research projects in the Mathematical Modelling of Infectious Diseases Unit, at Institut Pasteur in Paris. The postdocs will develop state...research.pasteur.fr

🦟 🦠 Notre équipe et celle de @simonlorierelab.bsky.social au sein du laboratoire "Génomique Évolutive, Modélisation et Santé" (GEMS) @cnrsecologie.bsky.social @pasteur.fr avons élucidé les déterminants génétiques viraux de la transmissibilité du #virus #Zika par le #moustique Aedes aegypti

CNRS Écologie & Environnement

#RésultatScientifique🔎 Une étude publiée dans Nature Communications analysent pourquoi les moustiques transmettent plus efficacement les souches africaines du virus Zika que les souches asiatiques. ➡️ www.inee.cnrs.fr/fr/cnrsinfo/...

🦟 🦠 Notre équipe du laboratoire "Génomique Évolutive, Modélisation et Santé" (GEMS) @cnrsecologie.bsky.social @pasteur.fr a identifié un gène clé impliqué dans la sensibilité du #moustique Aedes aegypti au #virus de la #dengue www.inee.cnrs.fr/fr/cnrsinfo/...

Un gène antiviral découvert chez les moustiques favorise la transmission de la denguePourquoi certains moustiques sont-ils plus susceptibles de transmettre la dengue que d’autres ?www.inee.cnrs.fr
⟳ Репост от The Lambrechts Lab

Kicking off the new year with mosquitoes, metabolomics, & arboviruses! 🥳 🦟Our new preprint is out! We mapped the metabolism of the Aedes aegypti mosquito across its life cycle to find new ways to fight dengue virus. Check it out on: doi.org/10.64898/202... #VectorBiology #Metabolomics #Mosquito

Stage-resolved metabolomics reveals the methionine cycle as a key regulator of Aedes aegypti development and dengue virus susceptibilityDevelopmental transitions in the mosquito Aedes aegypti are central to vector competence and disease transmission, yet the underlying metabolic programs remain poorly defined. Here, we use untargeted ...doi.org
Следующие публикации