Профиль

A "phytoscreen" of 43 fruits/vegetables reveals garlic as a potent deterrent of mating (up to 80% reduction) & egg laying in Drosophila, driven by diallyl disulfide. PMID:41999745, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00338-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A 14-protein plasma signature predicts lung cancer risk over 5 years ahead, enhancing prevention strategies post-CANTOS, despite high Treat NNT. Insightful! PMID:42242224, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00522-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cysteine's sulfur is split between glutathione & iron-sulfur clusters, crucially enhancing CD8⁺ T cell growth, effector function, & anti-tumor immunity. PMID:42276031, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00570-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Groundbreaking multi-omics & AI reveal 20+ senotype cell states in aging & disease, unveiling unique tissue programs & paving the way for 10+ senotherapeutics. PMID:42276030, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00587-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Deep-Phase is a neural network framework that analyzes microscopy images to link pharmacological changes to condensate morphology, advancing understanding of biomolecular organization. Key findings reveal… PMID:42242225, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00569-6

Rational design of Gi-biased CB1 agonists, LZD503 & LZD505, reduces side effects, advancing non-opioid therapies and targeting therapeutic efficacy in pain relief. PMID:41980782, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00287-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A new in vivo gene switch, activated by electromagnetic fields (EMFs), enables precise control of gene expression. Key discovery: Cyb5b acts as an EMF sensor. PMID:41985457, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00330-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A study "replayed" 100+ monoclonal germinal center reactions to map B cell affinity evolution, revealing dynamics crucial for enhancing antibody effectiveness. PMID:42248140, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00572-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Aging disrupts tissue homeostasis via mesenchymal drift, where cells lose identity and gain mesenchymal traits, linking multiple aging hallmarks in a feedback cycle. PMID:42208498, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00455-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Revolutionary findings show LEAPER 2.0 achieves long-term exon skipping in DMD, using circ-arRNAs for muscle regeneration in monkeys and humans. Exciting progress! PMID:42269605, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00589-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Single-cell profiling of DNA-protein interactions via D&D-seq reveals crucial insights into TF binding dynamics, chromatin accessibility, and histone modifications, advancing understanding of gene regulation. PMID:42242226, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00573-8

New ABA-inducible CRISPR-dCasRx tools for precise m⁵C RNA editing: dynamic, reversible, with minim… PMID:42286694, Genome Biol 2026 @OTSociety @NAR_Open https://doi.org/10.1186/s13059-026-04150-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

IDMME and IDMDE: inducible CRISPR-dCasRx platforms for spatiotemporal RNA m5C editing | Genome Biology | Springer Nature LinkRNA 5-methylcytosine (m5C) is a dynamic epigenetic mark implicated in tumorigenesis, however, existing editors lack spatiotemporal regulation and reversibidoi.org

Genomic instability can mislocalize DNA to cytoplasm, triggering intercellular transfer via cytoskeleton. This reveals unexpected pathways of DNA signaling. Fascinating! PMID:42161273, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00508-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cryo-EM reveals the VPS13A-BLTP complex with XK scramblase, elucidating lipid transfer mechanisms between organelles, highlighting 3D structural dynamics. PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Donor-derived CD19-CAR T cells post-allogeneic HSCT show that CAR-modified TSCM cells have 2-3x better expansion/persistence, leading to complete responses at low doses, no lymphodepletion needed! PMID:42066750, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00383-1 #Medsky #RNA 🧪

New insights reveal that the brain clears protein waste more efficiently than thought, tracing distinct drainage routes and hotspots to CSF using a non-invasive genetic system. PMID:42214342, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00515-5 #Medsky #Pharmsky #RNA #ASHG 🧪

A genome-scale genetic interaction map of HAP1 cells reveals ~89,000 interactions and organizes genes into modules linked to protein complexes. A game-changer for gene co-essentiality! PMID:42049019, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00345-4 #Medsky #Pharmsky #RNA 🧪

Study reveals how mouse primary olfactory system spatially maps social odors via MERFISH, detailing olfactory receptor expression in MOE & OB. Key insights boost understanding of sensory detection. 🐭✨ PMID:42054995, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00389-2 #Medsky 🧪

Introducing RegVelo: A novel deep learning framework that merges splicing kinetics & gene regulatory networks to enhance single-cell dynamics analysis. Key insights reveal mechanisms of cell fate transitions! PMID:42119563, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00457-5

New research highlights MARCH7 as a key E3 ubiquitin ligase that regulates ferroptosis by ubiquitylating NCOA4, maintaining intracellular iron homeostasis and preventing cell death. PMID:42049018, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00388-0 #Medsky #Pharmsky #RNA 🧪