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Профиль

Julia Frunzke

Профиль Vively

Professor at Forschungszentrum Jülich and HHU Düsseldorf. Phage-host interaction, regulatory networks, metabolic engineering, SPP 2330

⟳ Репост от Julia Frunzke

📰 Nice, @vbio.bsky.social (the German Life Sciences association) posts about our work with #bacteriophages in #Plant #Protection. 🧪 #PlantScience #SciCom www.vbio.de/aktuelles/de... @fz-juelich.de @frunzkelab.bsky.social @guidogrossmann.bsky.social

Viren als Pflanzenschützer: Das Potenzial von BakteriophagenBakterien können nicht nur Menschen und Tiere krank machen, sondern auch Pflanzen. Weltweit verursachen bakterielle Pflanzenkrankheiten erhebliche Ernteverluste. Für die Landwirtschaft ist das ein wac...www.vbio.de
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⟳ Репост от Julia Frunzke

2/10 The biological roles of most bacterial natural products remain unknown. A few were shown to provide antiphage phenotypes, as early as 1945 by Doris Jones and more recently by the @themaxwelllab.bsky.social and @frunzkelab.bsky.social labs. Ex: www.nature.com/articles/s41...

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⟳ Репост от Julia Frunzke

Latest science in press 🗞️: Biosustainable plant protection using #viruses (bacteriophages) 🧪 🦠 #PlantScience #botany #PlantMicrobeInteractions @fz-juelich.de @ceplas.bsky.social @mibinet.bsky.social www.fz-juelich.de/en/news/arch...

Viruses as Plant Protectors: Jülich Research Highlights the Potential of BacteriophagesResearchers at Forschungszentrum Jülich are investigating how natural viruses that specifically infect bacteria can help plants fight off bacterial pathogens. These bacteriophages open up new prospect...www.fz-juelich.deBorjana Arsova

‪ #Bacteriophages help sustainable plant protection ✅#Phages restore 🌱 growth during 🦠 infection. ✅🧬 shows ⬇️🌱immunity & ⬇️bacterial virulence. #Biocontroll #PlantSci 🧪 #PMI @frunzkelab.bsky.social @guidogrossmann.bsky.social @mibinet.bsky.social @fz-juelich.de www.cell.com/cell-reports...

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⟳ Репост от Julia Frunzke

www.hhu.de/news-einzela...

Mikrobiologie: Veröffentlichung in Cell ReportsForschende der Heinrich-Heine-Universität Düsseldorf (HHU) und des Forschungszentrums Jülich (FZJ) untersuchten, wie natürliche Viren, die gezielt Bakterien befallen („Bakteriophagen“), Pflanzen vor b...www.hhu.de
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⟳ Репост от Julia Frunzke

Our paper out in Science today: The Metis defense system senses molecular byproducts released when a phage degrades the bacterial genome, and then prevents replication of the phage in the infected cell Congratulations @ostermanilya.bsky.social and co-authors!

Bacteria sense virus-induced genome degradation via methylated mononucleotidesPhages often degrade the genome of their bacterial host to individual nucleotides. Here we describe Metis, a bacterial defense system that directly senses phage-mediated host genome degradation. Metis...www.science.orgOsterman Ilya

Excited to share that our Metis story is now published in Science! 🎉 Bacteria can sense phage-induced degradation of their genome and activate immunity. Many thanks to everyone who contributed to this work. 📄 www.science.org/doi/10.1126/... More details in my earlier thread 🧵⬇️

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⟳ Репост от Julia Frunzke

@sebastianbeier.bsky.social has fixed some minor issues in our read trimmer Trimmomatic for R0.41 since the latest release just a few months ago academic.oup.com/bioinformati.... github.com/usadellab/Tr.... Please note, that the website trimmomatic.com is not ours and send you to commercials.

Trimmomatic: a decade of feature-rich, high-performance NGS read preprocessingAbstractMotivation. Trimmomatic is a widely adopted tool for preprocessing high-throughput sequencing data, particularly from Illumina platforms. Since itsacademic.oup.com
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⟳ Репост от Julia Frunzke

Happy to share our latest finding on ComFB, a new #cdiGMP receptor in bacteria Team effort w/ @freecyano.bsky.social at @sfb1381.bsky.social ComFB regulates type IV pilus-dependent functions via sequestering TFs (CRP1/2) @hhu.de @biologyunifreiburg.bsky.social www.sciencedirect.com/science/arti...

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⟳ Репост от Julia Frunzke

🚨 Registration for VEGA26 is 👏 officially open 👏 🚨 The 5th edition of our Viral EcoGenomics and Applications symposium will be held November 18-19, 2026, on the UC Berkeley campus 🧬 🦠 🔬 🧫 Event website ➡️ jgi.doe.gov/work-with-us... Registration link ➡️ cvent.me/e0RnA0

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⟳ Репост от Julia Frunzke

How can we harness the vast functional diversity of microbes on our planet? Join us at EMBL Heidelberg from 8–10 December 2026 to hear about ongoing efforts to decode gene function and organisation in human gut microbes, and to present your own research. www.embl.org/about/info/c...

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⟳ Репост от Julia Frunzke

Open postdoc position in my lab on HGT and interbacterial competition. We seek candidates with a PhD in microbiology (or related fields)+ strong 1st-author publications. Curious, highly motivated, and dedicated team players ready to contribute fully are encouraged to apply. Details: tiny.cc/cz01101

Open Positions-tiny.cc
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⟳ Репост от Julia Frunzke

Beyond AMGs: Phage-encoded transcription and sigma factors as understudied virocell reprogramming tools #phage #phagesky Trends in Microbiology www.cell.com/trends/micro...

Beyond AMGs: Phage-encoded transcription and sigma factors as understudied virocell reprogramming toolsPhages, the most abundant biological entities on Earth, infect bacteria and reprogram them into ‘virocells’ with altered physiology and ecology. While metagenomic studies have largely inferred reprogr...www.cell.com
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⟳ Репост от Julia Frunzke

📣 We are hiring! In the collaborative research center 'Plant Ecological Genetics' @teamthomma.bsky.social searches a PhD candidate to study the role of plant-associated microbiota in plant density responses and inter-plant competition. See project A07: sl1nk.com/b7z0doc Deadline July 10!

Encurtador de LinkEncurtador de Link | O melhor encurtador de links e urls gratuito da internet.sl1nk.com
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⟳ Репост от Julia Frunzke

Dr. Michael Sauer, FEMS Board Member and ÖGMBT President, invites you to join him this year in Vienna as collaboration takes centre stage at the FEMS Regional COLLAB. Discover how collaboration can transform ideas into impact. ⏰ 23 June EB Deadline: buff.ly/pg2yXvN

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⟳ Репост от Julia Frunzke

As promised: We have an open 2-year postdoc position in my lab at HHU Düsseldorf, starting September 2026. Come join us and help pioneering structural biology of fungal GPCRs! More about the lab: altegoerlab.de Apply here: karriere.hhu.de/index.php?ac... Please share with interested candidates!

Postdoc (m/f/d) structural biology of fungal G-Protein coupled receptorskarriere.hhu.deAltegoerlab

We just received funding for a 2yr postdoc position on cryoEM of fungal gpcrs. Official call will open soon. Contact me if you‘re interested!

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⟳ Репост от Julia Frunzke

NAD to the bone: How bacteria put phages under aRES-t … and how phages fight back Preview of work IDing aRES, bacterial proteins that deplete cellular NAD+, generating products that cannot be utilized by phage NAD+ regeneration pathways www.cell.com/cell-host-mi...

NAD to the bone: How bacteria put phages under aRES-t … and how phages fight backIn this issue of Cell Host & Microbe, Osterman et al. discover aRES, a new family of bacterial immune proteins that deplete cellular NAD+, generating cleavage products that cannot be utilized by canon...www.cell.com
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⟳ Репост от Julia Frunzke

Our review on structural mechanisms of #CO2 fixation machinery by #cyanobacteria @theplantjournal.bsky.social is out🎉🎉 When #CO2 is limiting, #cyano concentrate it. Discover how they thrive? @hhu.de @ceplas.bsky.social @mibinet.bsky.social @sfb1381.bsky.social onlinelibrary.wiley.com/doi/10.1111/...

Functional and structural insights into cyanobacterial CO2 concentrating mechanisms: from compartmentalization to regulationLife on Earth depends on photosynthetic CO2 fixation via the Calvin–Benson–Bassham cycle to form organic carbon. This process evolved first in cyanobacteria and was later conveyed to eukaryotes, givi...onlinelibrary.wiley.com
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⟳ Репост от Julia Frunzke

#Biofilm matrices containing filamentous phages help #Pseudomonas aeruginosa tolerate antibiotics. @abultarafder.bsky.social @tbharat-lab.bsky.social &co show that #nanobody disruption of #phage Pf4 #LiquidCrystalline droplets restores #antibiotic susceptibility @plosbiology.org 🧪 plos.io/4xkd6Mw

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⟳ Репост от Julia Frunzke

Happy to share our latest pre-print on the Druantia defense system. We find that Type III Druantia uses a cooperative helicase-nuclease mechanism to sense and degrade replication-associated forked DNA structures. www.biorxiv.org/content/10.6... A🧵

www.biorxiv.org
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⟳ Репост от Julia Frunzke

Our paper is out! Hiding in plain sight among Cas12a nucleases, Cas12a3 cleaves not its RNA target but the 3′ ends of tRNA. Huge thanks to all who made this possible, especially the Beisel lab, Biao & Dirk for the structure, & @sebastianglatt.bsky.social for all things tRNA. doi.org/10.1038/s415...

RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial immunity - NatureCas12a3 nucleases constitute a distinct clade of type V CRISPR–Cas bacterial immune systems that preferentially cleave the 3′ tails of tRNAs after recognition of target RNA to induce growth arres...www.nature.com
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⟳ Репост от Julia Frunzke

David Attenborough has raised awareness of the natural world and its myriad interconnections on which humans depend go.nature.com/48RTqVz

Happy 100th birthday David Attenborough! Nature salutes youNature - The science communicator has raised awareness of the natural world andits myriad interconnections on which humans depend.go.nature.com
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