Principal Investigator at Leiden University Medical Center Host-Defence | Structural biology | Single-molecule Biophysics http://www.loefflab.com
Excited to see this online! The structure of the CAST type I holo-complex. Congrats to all involved! By the labs of @martinjinek.bsky.social & @sternberglab.bsky.social.
cryoEM papersStructural basis of RNA-guided DNA integration by type I CRISPR-associated transposases www.biorxiv.org/content/10.64898/2026.05.18.725949v1 #cryoEM
Happy to share our latest pre-print on the Druantia defense system. We find that Type III Druantia uses a cooperative helicase-nuclease mechanism to sense and degrade replication-associated forked DNA structures. www.biorxiv.org/content/10.6... A🧵
www.biorxiv.org