Профиль

It’s finally here! 🎉 Delayed a bit by the classic post-PhD lab change, but very happy to see this work published. Thank you @lionelguy.bsky.social and @sellinlab.bsky.social 😄

Most updates from our lab nowadays found at LinkedIn: www.linkedin.com/in/mikael-se...

Thrilled to share that our study on how the pcnB gene sustains Shigella virulence is now published in PLOS Pathogens: journals.plos.org/plospathogen... In short: pcnB ➝increased virulence-plasmid replication ➝ elevated T3SS expression ➝ enhanced invasion/spread within the intestinal epithelium.

The pcnB gene sustains Shigella flexneri virulenceAuthor summary Bacterial infections represent a major global threat. Understanding the genetic determinants promoting infections is crucial to overcome this threat. Shigella is an intracellular bacter...journals.plos.org

Organoider, miniatyrorgan som odlas från mänskliga stamceller, är mycket användbara i forskning. I framtiden kommer de ha en stor betydelse även inom transplantationsvården. #Organoid #UppsalaUniversitet #Forskning

Видео

@eurjimmunol.bsky.social

With key contributions from Grisna Isabel Prensa and Julia Andersson, and made possible through our long-standing collaboration with the Pejler laboratory.

Mast cell subsets respond uniquely to Salmonella infection. Read all about it in our latest paper in EJI. Another chapter in our deciphering of mast cell interactions with enterobacteria, driven by Chris von Beek. onlinelibrary.wiley.com/doi/10.1002/...

Mast Cell Phenotypic Heterogeneity Impacts the Interplay with Pathogenic Salmonella Typhimurium BacteriaMast cell phenotypic features influence anti-bacterial response. Connective tissue-like mast cells sense Salmonella through combined Toll-like-receptor (TLR) signaling and recognition of Type-III-sec....onlinelibrary.wiley.com

Such a rewarding collab it has been with our colleagues at #Novavax to dissect the MoA of their potent Matrix-M adjuvant. This project has really put the imaging skills of @erixoneriksson.bsky.social to the test. The fruits of this joint labour out now in NPJ Vaccines www.nature.com/articles/s41...

Matrix-M adjuvant triggers inflammasome activation and enables antigen cross-presentation through induction of lysosomal membrane permeabilization - npj Vaccinesnpj Vaccines - Matrix-M adjuvant triggers inflammasome activation and enables antigen cross-presentation through induction of lysosomal membrane permeabilizationwww.nature.com

Alert! The abstract deadline for the Microbial Pathogenesis & Host Response meeting has been extended to July 7 meetings.cshl.edu/meetings.asp...

Microbial Pathogenesis & Host ResponseCold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.meetings.cshl.edu

Thanks for the invitation to share our work and to see the wide span of efforts on understanding and controlling #salmonella presented at this weeks #I3S congress, set in beautiful St Malo. i3scongress.innozh.fr

Congrats, @alexandraboegli.bsky.social !

📢ONLINE @natgenet.nature.com 📰A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen. By @mldm.bsky.social, @lbarquist.bsky.social, Mikael E. Sellin and colleagues. ⬇️ www.nature.com/articles/s41...

A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen - Nature GeneticsA genome-wide screen using human gut epithelial organoids combined with transposon-directed insertion sequencing identifies over 100 Shigella flexneri genes required for epithelial colonization.www.nature.com

@mldm.bsky.social showcasing our recently published Shigella gut organoid infection screen at #EESMicrobiology this week.

The abstract submission deadline for Understanding and predicting microbial evolutionary dynamics 2025 is soon approaching! Make sure to submit by 23:59 BST on 7 July 2025. microb.io/Abstracts #MicroEvo25

New preprint out: www.biorxiv.org/content/10.1... We followed up on our recent Nature Genetics paper mapping Shigella colonization in intestinal organoids with a deep dive into one of the screen hits: pcnB. #Shigella #virulence #microsky

Thanks @sydneylmiles.bsky.social and @sergemostowylab.bsky.social for writing such a sharp and thoughtful editorial, which covers all the main points and potential caveats of our study published yesterday. www.nature.com/articles/s41...

Organoid models advance dysentery control - Nature GeneticsShigella is a major human pathogen with a stark lack of pipelines linking genome content to clinical pathogenesis. An innovative study using large-scale organoid models, combined with genome-wide muta...www.nature.com

Thanks @scilifelab.se for the highlight of our recently published study @natgenet.nature.com. Link to the full paper here: rdcu.be/eqGgf

The study would not have been possible without the relentless drive of @mldm.bsky.social and the very fruitful collaboration with Laura Jenniches and @lbarquist.bsky.social at the @helmholtz-hiri.bsky.social and many other colleagues. @andrenmateus.bsky.social, @erixoneriksson.bsky.social

Our latest work combines human gut epithelial #organoid culture with experimental #Shigella #infections, transposon mutagenesis, and statistical modeling. This has led to the mapping of the comprehensive geneset that drives Shigella epithelial colonization. Out @natgenet.nature.com: rdcu.be/eqGgf

A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogenNature Genetics - A genome-wide screen using human gut epithelial organoids combined with transposon-directed insertion sequencing identifies over 100 Shigella flexneri genes required for...rdcu.be

I enjoyed this NPR story but thought it was a bit unclear regarding the origin of the name "Salmonella" and who should be credited with its discovery.