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📢PUBLISHED @natgenet.nature.com 📰Genome-wide association analyses of gestational phenotypes identify context-specific genetic effects. By Siyang Liu, Fengxiang Wei and colleagues. ⬇️ www.nature.com/articles/s41...

Genome-wide association analyses of gestational phenotypes identify context-specific genetic effects - Nature GeneticsGenome-wide analyses in up to 121,579 pregnant women from China identify genetic associations across 111 phenotypes, including gestation-specific effects and interactions with gestational timing.www.nature.com

📢PUBLISHED @natgenet.nature.com 📰Intrinsically disordered regions restrain genomic targeting of RNA and histone demethylases in mammals and plants. By Liudan Jiang, Chuan He and colleagues. ⬇️ www.nature.com/articles/s41...

Intrinsically disordered regions restrain genomic targeting of RNA and histone demethylases in mammals and plants - Nature GeneticsIntrinsically disordered regions impose regulatory restraints on gene-activating demethylases, limiting chromatin engagement and preserving genomic stability. This function is a key determinant of the...www.nature.com

📢PUBLISHED @natgenet.nature.com 📰Pangenome-resolved structural variation drives adaptation and trait evolution in cucumber. By Jiantao Guan, Shengping Zhang and colleagues. ⬇️ www.nature.com/articles/s41...

Pangenome-resolved structural variation drives adaptation and trait evolution in cucumber - Nature GeneticsPangenome analyses of chromosome-scale genome assemblies for 125 diverse cucumber accessions highlight structural variation shaped by selection for geographical adaptation, fruit-length diversificatio...www.nature.com

📢PUBLISHED @natgenet.nature.com 📰SUMOylation enhances DNMT1 function to repress mega-intergenic RNAs and viral mimicry. By Brian J. Liddicoat, Jesse J. Balic, @mafdawson.bsky.social and colleagues. ⬇️ www.nature.com/articles/s41...

SUMOylation enhances DNMT1 function to repress mega-intergenic RNAs and viral mimicry - Nature GeneticsThis study uses a highly selective inhibitor to elucidate DNMT1’s specific functions and their regulation. Notably, RFN4-mediated SUMOylation enhances DNMT1 mobility and DNA methylation, thereby promo...www.nature.com

📢PUBLISHED @natgenet.nature.com 📰Promoter strength and position govern promoter competition through transcript-dependent insulation. By Mervenaz Koska, Joanna Wysocka and colleagues. ⬇️ www.nature.com/articles/s41...

Promoter strength and position govern promoter competition through transcript-dependent insulation - Nature GeneticsBy inserting diverse promoters at the mouse Sox2 locus, Koska et al. show that promoter strength, position and transcript length tune promoter competition through transcription-dependent insulation, i...www.nature.com

📢PUBLISHED @natgenet.nature.com 📰Genome-wide association analyses of borderline personality disorder identify 11 loci and highlight shared risk with mental and somatic disorders. By Fabian Streit, Stephanie H. Witt and colleagues. ⬇️ www.nature.com/articles/s41...

Genome-wide association analyses of borderline personality disorder identify 11 loci and highlight shared risk with mental and somatic disorders - Nature GeneticsGenome-wide association analyses identify risk variants for borderline personality disorder and find genetic correlations with psychiatric disorders, behavioral traits and somatic diseases.www.nature.com

📢PUBLISHED @natgenet.nature.com 📰Pioneer transcription factors direct tissue-specific cohesin chromatin entry and three-dimensional genome organization. By Song Wang, Haiyang Guo and colleagues. ⬇️ www.nature.com/articles/s41...

Pioneer transcription factors direct tissue-specific cohesin chromatin entry and three-dimensional genome organization - Nature GeneticsAnalyses in prostate cancer cell lines show that FOXA1 mediates tissue-specific recruitment of NIPBL to chromatin to orchestrate three-dimensional genome organization, acting in concert with ETS1 and ...www.nature.com

💫PUBLISHED @natgenet.nature.com 📰Longitudinal changes in DNA methylation in IDH-mutant glioma fuel disease progression through altered cell state differentiation. By @masashi-nomura.bsky.social, @landau.bsky.social, Mario L. Suvà and colleagues. ⬇️ www.nature.com/articles/s41...

Longitudinal changes in DNA methylation in IDH-mutant glioma fuel disease progression through altered cell state differentiation - Nature GeneticsThe authors use single-cell multi-omics to interrogate longitudinal samples of isocitrate dehydrogenase mutant gliomas. Their analyses couple progression and hypomethylation with changes in differenti...www.nature.com

📢PUBLISHED @natgenet.nature.com 📰A progeria syndrome links DNA hypermethylation to age-related pathology. By Dan Sarni, Andrew Jackson and colleagues. ⬇️ www.nature.com/articles/s41...

A progeria syndrome links DNA hypermethylation to age-related pathology - Nature GeneticsThis study investigates the consequences of hypermethylation in a progeria syndrome caused by gain-of-function DNMT3A mutations, finding effects on adult stem cell function.www.nature.com

✨PUBLISHED @natgenet.nature.com 📰Multiscale analysis and functional validation of the cellular and genetic determinants of skeletal disease. By Ryan C. Chai, John P. Kemp and colleagues. ⬇️ www.nature.com/articles/s41...

Multiscale analysis and functional validation of the cellular and genetic determinants of skeletal disease - Nature GeneticsThe study integrates cross-species single-cell and genomic analyses with functional validations to map the endosteal bone compartment, revealing musculoskeletal-disease-relevant cell types and transcr...www.nature.com

📢@natgenet.nature.com July issue's out! Featuring: ✅special focus on BRCA1 and BRAC2 ✅in vivo Perturb-seq of MDD risk genes ✅human vaginal microbiome genomic landscape ✅Chron's Disease single-cell RNA seq atlas ✅a graph-based mung bean pan-genome and much more! ⬇️ www.nature.com/ng/volumes/5...

@natgenet.nature.com is looking to hire a Cancer editor! Please repost and share with your contacts! This is a rare and exciting opportunity. springernature.wd3.myworkdayjobs.com/SpringerNatu...

Associate or Senior Editor, Nature GeneticsJob Title: Associate or Senior Editor, Nature Genetics Location: Shanghai, Beijing, Madrid, Milan or Pune, Hybrid Working Model Application Deadline: Aug 3rd, 2026 About Springer Nature Springer Natur...springernature.wd3.myworkdayjobs.com

📢PUBLISHED @natgenet.nature.com 📰 Interpretable, flexible and spatially aware integration of multiple spatial transcriptomics datasets from diverse sources By Jia Zhao, Hongyu Zhao and colleagues. ⬇️ www.nature.com/articles/s41...

Interpretable, flexible and spatially aware integration of multiple spatial transcriptomics datasets from diverse sources - Nature GeneticsINSPIRE addresses challenges to integrating diverse spatial transcriptomics datasets by combining deep learning with non-negative matrix factorization, revealing shared and context-specific spatial ge...www.nature.com

📢 PUBLISHED @natgenet.nature.com 📰Tumor DNA methylation subtypes predict immunotherapy outcomes in pleural mesothelioma patients in the NIBIT-EPI-MESO study By Luana Calabrò, Michele Ceccarelli, Michele Maio and colleagues. ⬇️ www.nature.com/articles/s41...

Tumor DNA methylation subtypes predict immunotherapy outcomes in pleural mesothelioma patients in the NIBIT-EPI-MESO study - Nature GeneticsProfiling of pleural mesothelioma samples from 91 patients identifies four DNA methylation subtypes that correlate with response to immune checkpoint inhibition and survivalwww.nature.com

📢 PUBLISHED @natgenet.nature.com 📰Genomic analyses implicate hormonal and metabolic dysregulation in polycystic ovary syndrome By Loes M. E. Moolhuijsen, Corrine K. Welt, Tugce Karaderi, Felix R. Day and colleagues. ⬇️ www.nature.com/articles/s41...

Genomic analyses implicate hormonal and metabolic dysregulation in polycystic ovary syndrome - Nature GeneticsGenome-wide analyses identify genetic loci and plasma proteins associated with polycystic ovary syndrome (PCOS). This study highlights the hormonal and metabolic foundations of the disease and explore...www.nature.com

📢OUT TODAY @natgenet.nature.com 📰Limited overlap between genetic effects on disease susceptibility and disease survival. By Zhiyu Yang, Nina Mars, Andrea Ganna and colleagues. ⬇️ www.nature.com/articles/s41...

📢OUT @natgenet.nature.com 📰Bryophytes hold a larger gene family space than vascular plants. By Shanshan Dong, Yang Liu and colleagues. ⬇️ www.nature.com/articles/s41...

Bryophytes hold a larger gene family space than vascular plants - Nature GeneticsA super-pangenome analysis incorporating 123 newly sequenced bryophyte genomes reveals that bryophytes exhibit a larger number of unique and lineage-specific gene families than vascular plants.www.nature.com

📢PUBLISHED @natgenet.nature.com 📰Rapid epigenomic classification of acute leukemia By Til L. Steinicke, Gabriel K. Griffin, Volker Hovestadt and colleagues. ⬇️ www.nature.com/articles/s41...

Rapid epigenomic classification of acute leukemia - Nature GeneticsThe authors present a molecular classification of acute leukemia using 5-methylcytosine signatures, together with a neural network-based classifier for clinical use.www.nature.com

📢PUBLISHED @natgenet.nature.com 📰Pan-UK Biobank genome-wide association analyses enhance discovery and resolution of ancestry-enriched effects. By Konrad J. Karczewski, Alicia R. Martin and colleagues. ⬇️ www.nature.com/articles/s41...

Pan-UK Biobank genome-wide association analyses enhance discovery and resolution of ancestry-enriched effects - Nature GeneticsGenome-wide analyses for 7,266 traits leveraging data from several genetic ancestry groups in UK Biobank identify new associations and enhance resources for interpreting risk variants across diverse populations.www.nature.com

📢PUBLISHED @natgenet.nature.com 📰Genetic and epigenetic screens in primary human T cells link candidate causal autoimmune variants to T cell networks. By Ching-Huang Ho, John P. Ray and colleagues. ⬇️ www.nature.com/articles/s41...