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"Here we apply DNA Typewriter, a prime editing-based recorder that writes stochastic symbolic insertions to an engineered genomic TAPE in strictly sequential order, to trace mouse development from zygote (E0) to late organogenesis (E13.5)" www.biorxiv.org/content/10.6...

In vivo reconstruction of the cell lineage history of a developing mouse with DNA Typewriter, from zygote to late organogenesisThe complete cell lineage of C. elegans, mapped over four decades ago, was tractable because the animal is small, transparent, and lineage invariant. Most animals are none of these, having orders of m...www.biorxiv.org

Flo’s excellent summary is the perfect illustration of how science works. We uncover new data and change or refine our understanding and our hypotheses Pretending otherwise is misrepresenting (or perhaps outright ignoring, though some people should know better) reality

RNA-seq tells us how much RNA is present in the cell. But to understand gene regulation, we need to easily measure the synthesis and decay rates driving this abundance. We introduce AIR-seq: analog intrinsic recoding sequencing. (1/6) www.biorxiv.org/content/10.6...

Analog intrinsic recoding measures RNA dynamics without chemical conversionSteady-state RNA abundance measurements mask the synthesis and decay rates that shape gene expression. Analog intrinsic recoding sequencing (AIR-seq) repurposes the base-pairing properties of N4-hydro...www.biorxiv.org

Am about to lift the following from a thread I did once in the Olim Bird Place, but if I leave a legacy behind, please let it be the legacy of coining the term The Chortlemuffin effect. The Chortlemuffin Effect describes a citational chain leading to bullshit. /1

Beyond providing insight into the centromere paradox, this work demonstrates that complete chromosome reconstruction is now possible from wild-caught flies, opening new opportunities for population, functional, and quantitative genomics in Drosophila. Preprint here: www.biorxiv.org/content/10.6...

A conserved architectural domain shapes centromere evolution in DrosophilaCentromeres ensure faithful chromosome segregation despite being embedded within rapidly evolving repetitive DNA, a contradiction known as the centromere paradox. While centromere identity is defined ...www.biorxiv.org

It will continue to grow and spin out of control the longer we ignore it I understand that competition for attention is very tough in this crazy world, but as Kai says this Ebola outbreak is something that should be receiving a lot more attention- and a lot more help

New -cytosis term has dropped on bioRxiv "We term this process ‘skoupocytosis’ after the Greek word for garbage” www.biorxiv.org/content/10.6...

Microglia extract neuronal proteolytic organelles via skoupocytosisNeurons face unique challenges in maintaining protein homeostasis due to their tortuous morphology and extended processes. Proteolytic organelles are typically transported retrogradely towards their s...www.biorxiv.org

Check out this either somewhat significant or highly significant factoid.

A great new resource for future comparisons across model systems, species, and disease states, on @biorxivpreprint.bsky.social: a consensus atlas of human brain development, identifying cell type-specific maturation trajectories across the lifespan 🧪🧬🧠📈 www.biorxiv.org/content/10.6...

A consensus atlas of human brain development defines cell type-specific maturation trajectories across the lifespanHuman neurodevelopment is a continuous process that begins prenatally and extends into postnatal life. Current transcriptomic datasets are limited, fragmented across analytical frameworks, precluding ...www.biorxiv.org

Could Excel be conscious? We surveyed more than Jan 1 1900 people to find out.

It took quite a bit of digging through the replies and quote tweets to understand what Thorp is and isn't saying here, but people dunking by saying gpt isn't a search engine have misunderstood. He's saying he used gpt to retrieve links to specific references he was previously familiar with.