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Excited to share a 6 yr long journey to develop & validate a biomarker-based acute #Lyme disease diagnostic test using urine. Herculean effort by Osas and Saadman, which wouldn’t have be possible w/o outstanding collabs @harvard.edu, @tuftslyme.bsky.social, @pireschembio.bsky.social #Microsky

🆒 new pub! Rapid evolution of Klebsiella pneumoniae biofilms in vitro -> adaptations selected during infection by @gretazabo.bsky.social & Linus Sandegren *hypermucoidy evolves via 📈c-di-GMP, overlaps w/ mutations in UTI and wound isolates. *pleasure to advise this! www.nature.com/articles/s41...

Rapid evolution of Klebsiella pneumoniae biofilms in vitro delineates adaptive changes selected during infection - Nature CommunicationsBiofilm formation on implanted medical devices facilitates infection by the pathogen Klebsiella pneumoniae. Here, Zaborskytė et al. use experimental evolution to show that the bacteria rapidly evolve ...www.nature.com

Advancing “Science of Science” Research to Understand and Strengthen the Biomedical Research Ecosystem 🧪 "This topic encourages research projects focused on a better understanding of the biomedical research ecosystem and strengthening the study of the 'science of science' within biomedicine."

‼️Please share‼️ Nemudryi lab is looking for postdocs to join our team and study: 🦠 Bacterial phage defense mechanisms 🧬 RNA repair & CRISPR-based RNA editing Excited about RNA, host-virus interactions & mechanistic biology? Let's talk! Apply: explore.jobs.ufl.edu/en-us/job/53...

📣Huge preprint 🔔 Today we share something our group has been working toward for a long time, led by @lucasmoriniere.bsky.social We asked can we predict which receptor a phage targets from its genome sequence alone? For most phages, we couldn’t. So Lucas set out to do something I had only dreamed of.

New paper 🔔 Collaboration @sullivan-lab.bsky.social Marissa Gittrich led the work Klebsiella phage biology has focused almost entirely on capsulated strains, but capsule loss is the #1 resistance mechanism under phage predation. We used a naturally acapsular host to reveal the receptor landscape

🚨Preprint! Happy to share the research from my PhD “Genome delivery of a contractile tailed phage and its superinfection exclusion mechanism”. We use cryoEM to study the genome ejection of the phage T4, revealing how the tape measure protein regulates the process. www.biorxiv.org/content/10.6...

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🖥️ 🧬 ⚛️ 🔬 Plz spread the word. 2-week computational biology workshop in Singapore. No registration fee or expenses for US citizens. Protein annotation, function, structural modeling, and simulation. ~35 attendees. Lectures and hands-on tutorials with intensive instructor interaction. compbioasia.net

📣new preprint from the phagefoundry.org team 🎉 Jessica Trinh and Catherine Mageeney (Sandia National Laboratories)!! Systematic analysis of prophages from ~1000 Acinetobacter baumannii isolates, induction & screening. We found this 😎 looking phage with bunch of 💍💍

🧵 New preprint! Our 4-lab team evolved Streptococcus pneumoniae in antibiotic-treated mice of varying immune states and discovered something surprising: bacteria rarely evolved resistance. Instead, they found a different way to survive — by rewiring RNA turnover. 🔗 www.biorxiv.org/content/10.6...

Happy to share a preprint—the last chapter of my dissertation with @mcsymbiont.bsky.social and Co—on what happens when bacterial endosymbionts accumulate huge numbers of pseudogenes during early genome reduction. www.biorxiv.org/content/10.6...

Check out our exciting new paper out now in @plos.org where Dr Ahmad manipulated #peptidoglycan chemistry to understand Lyme disease and arthritis 👇👏 #Microsky #glycotime journals.plos.org/plospathogen...

Peptidoglycan architecture dictates protein interactions, tissue tropism, and arthritis in the Lyme disease spirochete Borrelia burgdorferiAuthor summary Many of the pathogenic mechanisms by which Borrelia burgdorferi causes disease involve cell envelope interactions with host components. To further elucidate the role of peptidoglycan in...journals.plos.org

I’m thrilled to share our work on phage triggers of the bacterial immune system in its final form @natmicrobiol.nature.com www.nature.com/articles/s41...

A phage protein screen identifies triggers of the bacterial innate immune system - Nature MicrobiologyA library of 400 phage protein-coding genes is used to find a trove of antiphage systems, revealing systems that target tail fibre and major capsid proteins.www.nature.com

Are you a graduate student or postdoc who wants to apply your science to policy? The Gulf Research Program’s Science Policy Fellowship provides experience for one year on the staff of federal, state, local, NGO in the Gulf region and impt networking. www.nationalacademies.org/programs/GUL...

Gulf Research Program Science Policy FellowshipsThe Gulf Research Program’s Science Policy Fellowship helps scientists hone their skills by putting them to practice for the benefit of Gulf Coast communities and ecosystems. Fellows gain first-hand e...www.nationalacademies.org

Here, we find that many Genomic islands have origins of transfer (oriT) mobilisable by conjugation, incl. known Pathogenicity & defense islands. iOriT use only an oriT for transfer by hitching on conjugative elements: they make abundant, diverse, ancient families of mobile genetic elements. See🧵

🚨Call for papers🚨 Microbial Evolution: Impacts on Human Health in the society journal Evolution, Medicine, and Public Health Guest Editors: Bob Woods, Silvie Huijben & Camilo Barbosa EIC: me This will be great, please submit and share! academic.oup.com/emph/pages/m...

A prophage-encoded sRNA limits phage infection of adherent-invasive E. coli #PLoSPathogen from @prsecor.bsky.social journals.plos.org/plospathogen...

A prophage-encoded sRNA limits phage infection of adherent-invasive E. coliAuthor summary Prophages—viral genomes integrated into bacterial chromosomes—are common in enteric bacteria and can profoundly influence bacterial physiology and ecological fitness. Here we show that ...journals.plos.org

The final form of my 2nd postdoc paper with the Bassler Lab! Turns out our favorite quorum-sensing phage isn’t a one-off, but rather a member of a globally dispersed family of phages that sense a universal autoinducer. #phagesky #microsky journals.asm.org/doi/10.1128/...

A family of linear plasmid phages that detect a quorum-sensing autoinducer exists in multiple bacterial species | mBioThe discovery of quorum-sensing responsive linear plasmid phages has transformed understanding of phage-bacterial interactions by demonstrating inter-domain chemical communication. To date, however, e...journals.asm.org

Bacterial genomes encode a rich repertoire of antiphage systems, but we still know surprisingly little about when these systems are actually expressed. In this preprint, Lucas Paoli et al, ask what shapes antiphage systems expression in native contexts. www.biorxiv.org/content/10.6...

Environment and physiology shape antiphage system expressionBacteria and archaea encode on average ten antiphage systems. Quorum sensing, cellular, or transcription factors can regulate specific systems (CRISPR-Cas, CBASS). Yet, a systematic assessment of anti...www.biorxiv.org

Phages are full of genes of unknown function that are likely adaptive in specific conditions. New preprint: Phage TnSeq identifies essential genes rapidly and knocks all non-essentials. We would like to send a pool of phiKZ mutants to anyone wanting it! Reach out tinyurl.com/bdcfrejh