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Check out this wonderful piece by @vcallier.bsky.social on how parts of the human immune system can be traced back to the conflict between bacteria and phages!

Out now–our work on bacterial cGAS-like enzymes making 2′,3′-cGAMP! Read Uday's thread for updates since the preprint including determining our lab's first protein structure and developing a new system to study bacterial STING homologs in phage defense👇

I’m thrilled to share our work on phage triggers of the bacterial immune system in its final form @natmicrobiol.nature.com www.nature.com/articles/s41...

A phage protein screen identifies triggers of the bacterial innate immune system - Nature MicrobiologyA library of 400 phage protein-coding genes is used to find a trove of antiphage systems, revealing systems that target tail fibre and major capsid proteins.www.nature.com

Our work on the Panoptes antiphage system is published! Here we find that Panoptes "watches" the cytosol for phage immune evasion proteins–captured in this illustration by Clair Huffine of Insight Illustrations. A beautiful example of the effector triggered immunity paradigm.

Our new work understanding how phages are detected by the bacterial immune system is posted on bioRxiv! Check out Toni’s thread for a synopsis👇

Check out our new study on how bacteria defend themselves against a peculiar clade of organisms – predatory bacteria! This work was a monumental effort led by @hannahledvina.bsky.social (see her excellent summary👇). The bacterial immune system continues to amaze me...