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Профиль

Paul Flicek

Профиль Vively

Data, genomics, evolution, science 🇺🇸🇬🇧

⟳ Репост от Paul Flicek

Monumental new paper from a great collaboration full of exceptional humans! www.nature.com/articles/s41...

Genetic background sets the trajectory of experimental cancer evolution - NatureExperimentally replaying tumour evolution in divergent mouse strains reveals the importance of interactions between genetic ancestry and acquired cancer-driving mutations in shaping the earliest stage...www.nature.com
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⟳ Репост от Paul Flicek

🧬NEW PAPER🧬 To what extent is cancer development deterministic? Does the germline genome affect that predictability? Find out in our #StrainDifferences paper @nature.com "Genetic background sets the trajectory of experimental cancer evolution" www.nature.com/articles/s41... 🧵[1/14]

Genetic background sets the trajectory of experimental cancer evolution - NatureExperimentally replaying tumour evolution in divergent mouse strains reveals the importance of interactions between genetic ancestry and acquired cancer-driving mutations in shaping the earliest stage...www.nature.com
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⟳ Репост от Paul Flicek

Simons Graduate Fellowships in #Ecology and #Evolution #science #scienceSky #evoSky www.simonsfoundation.org/grant/simons...

Simons Graduate Fellowships in Ecology and EvolutionThe purpose of these awards is to provide support for students entering U.S.-based Ph.D. programs with a plan to perform research in ecology and evolution. While we will consider all projects in ecolo...www.simonsfoundation.org
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⟳ Репост от Paul Flicek

Friday was my last day at NHGRI. After 10 wonderful years, my lab is headed to Johns Hopkins University genomeinformatics.github.io/movingday/

We're moving!Friday was my last day at NHGRI. After 10 wonderful years, my lab is headed one hour north on I-95 to set up shop at Johns Hopkins University. This is a very bittersweet move for me, as NHGRI has prov...genomeinformatics.github.io
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⟳ Репост от Paul Flicek

Look at the women at NASA. They are the ones pushing the boundaries of science, solving problems most people can’t even understand, and carrying this country forward, while our politicians right now posture and stumble through talking points. And they are doing it all with joy.👇

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⟳ Репост от Paul Flicek

Genome Biology and Evolution launches a new virtual collection on "Conservation Genomics" Read our accompanying Highlight: "Genome Science at the Forefront of Biodiversity's Greatest Challenges" 🔗 buff.ly/qBGcsG7 Access the new virtual collection 🔗 buff.ly/VxXZUKv #genome #evolution #congen

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⟳ Репост от Paul Flicek

Crushed to hear of Mark Batzer’s passing. He was the Boyd Professor at Louisiana State University. His influential research revealed how mobile elements shape the genomes of humans & other mammals. Mark’s personality, generosity & positivity were larger than life. He lifted everyone up. HUGE loss 💔

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⟳ Репост от Paul Flicek

Currently dorking out over this graph about child mortality with my brother. Just mind boggling to take in.

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⟳ Репост от Paul Flicek

My lab at hiring! - we have TWO postdoc positions (one computational, one wet lab focussed) at Yale @yaleschoolofmed.bsky.social, working closely with our group members at University of Cambridge, UK @cambridgeuni.bsky.social Please help to spread the word! Adverts with full details below ⬇️

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⟳ Репост от Paul Flicek

🌟NEW PREPRINT ALERT!🌟 We are very pleased to introduce #StrainDifferences: “Genetic background sets the trajectory of cancer evolution” www.biorxiv.org/content/10.1... 🧵[1/12]

Genetic background sets the trajectory of cancer evolutionHuman cancers are heterogeneous. Their genomes evolve from genetically diverse germlines in complex and dynamic environments, including exposure to potential carcinogens. This heterogeneity of humans,...www.biorxiv.org
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⟳ Репост от Paul Flicek

Associate Professor / Professor of Evolutionary Genomics www.jobs.cam.ac.uk/job/49389/

Associate Professor / Professor of Evolutionary Genomics - Job Opportunities - University of CambridgeAssociate Professor / Professor of Evolutionary Genomics in the Department of Genetics at the University of Cambridge.www.jobs.cam.ac.uk
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⟳ Репост от Paul Flicek

Abstract submissions are still open for the CSHL Network Biology meeting in March 11 - 15 2025 (abstract deadline: Jan 10). A large fraction of talks will be selected from the abstracts. On behalf of the organizers, we look forward to welcoming you there. meetings.cshl.edu/meetings.asp...

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⟳ Репост от Paul Flicek

8/tl;dr: In most situations, it is to the author's maximal benefit to license their manuscripts thusly: preprints: any CC license journal publication: CC BY only 🧪 #AcademicSky

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⟳ Репост от Paul Flicek

The use of the phrase “ancestry-specific variant” is increasing, particularly to describe rare Single-nucleotide variants (SNVs). But these alleles are not ancestry-specific. They have not yet been found elsewhere, but they will be. 1/n

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⟳ Репост от Paul Flicek

At the forefront of research involving long-read sequence data, JAX's @christinebeck.bsky.social & Peter Audano discuss how adjustments to the technical and analytical infrastructure are needed. Read more in their recent Genome Research paper 🧪🤝🖥️ 🧬 : www.jax.org/news-and-ins...

Improving whole genome sequence data analysesChristine Beck and Peter Audano are at the forefront of research involving long-read sequence data. They are particularly interested in structural variants, where segments of the genome are deleted, i...www.jax.org