MBE publishes fresh insights into the patterns and processes that impact the evolution of life at molecular levels. 🔗 academic.oup.com/mbe 🏠 @official-smbe.bsky.social 🤝 @genomebiolevol.bsky.social #evobio #molbio #science #biology #societyjournal
If you think sex chromosomes in mammalian placentas are interesting you’ll want to know about seahorses academic.oup.com/mbe/article/...
Independent Evolution of Sex Chromosomes and Male Pregnancy–Related Genes in Two Seahorse SpeciesAbstract. Unlike birds and mammals, many teleosts have homomorphic sex chromosomes, and changes in the chromosome carrying the sex-determining locus, termeacademic.oup.com
I got tired of doomGPTing so moved onto doomMBEing recently academic.oup.com/mbe/article/...
Reconstruction of Ancestral Protein Sequences Using Autoregressive Generative ModelsAbstract. Ancestral sequence reconstruction (ASR) is an important tool to understand how protein structure and function changed over the course of evolutioacademic.oup.comthis is relieving academic.oup.com/mbe/article/...
Robustness of Ancestral Sequence Reconstruction to Among-site and Among-lineage Evolutionary HeterogeneityAbstract. Ancestral sequence reconstruction is typically performed using homogeneous evolutionary models, which assume that the same substitution propensitacademic.oup.com
We (@rileyshultz.bsky.social) tracked a recessive mutation from birth to death in honey bees. It causes ivory eyes. We collaborated across the continent to identify the mutation and it's downstream effects. Ultimately it is purified through selection on drones. We think Hamilton would be pleased!
Molecular Biology and EvolutionShultz @beeharpur.bsky.social et al. documented the trajectory of a spontaneous deleterious mutation from its origin in a single queen to its extinction, directly observing how haplodiploidy exposes recessive alleles to immediate purifying selection 🔗 doi.org/10.1093/molbev/msag156 #societyjournal
Chen, Qu & Zhang perform kingdom-wide evolutionary analyses across 364 Archaeplastida genomes and find massive PPR gene expansions in early-diverging land plants, predominantly driven by dispersed duplication associated with retroposition. 🔗 doi.org/10.1093/molbev/msag168 #societyjournal #PlantSky
Kingdom-wide evolutionary characterization of RNA editing factors in ArchaeplastidaAbstract. RNA editing, a post-transcriptional modification in plant mitochondria and plastids, is essential for environmental adaptation and diverse physiodoi.orgKayhani et al. find that introgression of warm-adapted alleles was largely successful despite the risk of introducing mitonuclear incompatibilities that could result from genome-wide shifts toward the paternal allele in Tigriopus californicus. 🔗 doi.org/10.1093/molbev/msag158 #societyjournal
Introgression of thermal tolerance alleles drives adaptation despite risk of mitonuclear conflictAbstract. Hybridization may offer a form of genetic rescue from warming temperatures through the introgression of heat-adapted alleles from a high-tolerancdoi.org@prateekverma.bsky.social Albari & Marshall evaluate the potential of Y-linked genome editors to suppress or eliminate a mouse population on a small, isolated island - results suggest YLEs as a promising, ecologically manageable biocontrol tool 🔗 doi.org/10.1093/molbev/msag165 #societyjournal
Y-linked editors for invasive rodent controlAbstract. Invasive rodents are major contributors to biodiversity loss, particularly on islands where native species have evolved in their absence. Geneticdoi.orgGarrecht, @plantevodevo-ab.bsky.social et al. conducted a comprehensive analysis of streptophyte algae and land plants, finding that the LUG and SEU genes have existed for at least 800 Myr, with specific domains remaining nearly invariant. 🔗 doi.org/10.1093/molbev/msag154 #societyjournal #PlantSky
800 million years of co-evolution in the green plant lineage: the case of LEUNIG and SEUSS transcriptional co-regulatorsAbstract. The evolution of land plants has involved significant restructuring and expansion of gene networks responsible for developmental processes, leadidoi.orgZhu, Zhuo & Zhen show that natural selection has shaped the evolution of CTCF binding sites in primates, driving both conservation and innovation in chromatin organization and contributing to human-specific regulatory evolution. 🔗 doi.org/10.1093/molbev/msag167 #societyjournal #evobio
Evolution of CTCF binding sites in the human genomeAbstract. The CCCTC-binding factor (CTCF) is a master regulator of topologically associating domains (TADs), which shape 3D genome architecture and gene redoi.orgHuang et al. elucidate a unique biomineralization strategy in the apple snail and identify potential molecular targets for disrupting capsule formation, offering new avenues for controlling this globally invasive species. 🔗 doi.org/10.1093/molbev/msag164 #societyjournal #evobio #invasive
Egg capsule mineralization via vaterite transportation in the invasive apple snail Pomacea canaliculataAbstract. The invasive apple snail Pomacea canaliculata utilizes calcified egg capsules as a key adaptation for terrestrial reproduction; however, the biomdoi.org
Genomic Imprint of Chromosomal Inversions and Demographic History in Island Populations of Deer Mice academic.oup.com/mbe/article/...
The Genomic Imprint of Chromosomal Inversions and Demographic History in Island Populations of Deer MiceAbstract. Populations that colonize islands experience novel selective pressures, fluctuations in size, and changes to their connectivity. Owing to their uacademic.oup.com
New article! I had the pleasure of collaborating (also with @fcocubillosr.bsky.social, Claudio Martínez & @litinice.bsky.social) on this work, led by Dr Francisco Salinas, investigating the genomic structure of a horizontally acquired region (Region B) in #yeast. academic.oup.com/mbe/article/...
Genetic background shapes the transcriptional activity and phenotypic contribution of a horizontally acquired region in yeastAbstract. Horizontal Gene Transfer (HGT) is the movement of genetic material across species. In Saccharomyces cerevisiae, a DNA segment known as Region B wacademic.oup.com@jechave.bsky.social & Carpentier extend the Mutation-Stability-Activity model for enzyme sequence evolution, identifying constraints that operate in each enzyme family, exploring their relative importance, and biophysical and selective determinants 🔗 doi.org/10.1093/molbev/msag162 #societyjournal
Why structural divergence varies among residues in enzyme evolution: contributions of mutation, stability, and activity constraintsAbstract. In enzyme evolution, structural divergence varies among residues, forming residue-dependent structural divergence profiles. The evolutionary consdoi.org
In a new paper, IGI researchers at UC Berkeley & UC San Diego develop a novel approach to controlling invasive rodent populations: Y-linked genome editors, combining scalability with a level of control that has previously been difficult to achieve: https://ow.ly/8mMx50Zs8of 🧪
Our new paper on Y-linked CRISPR editors for invasive rodent control is featured by @innovativegenomics.bsky.social. innovativegenomics.org/news/a-new-a... #CRISPR #RodentControl
A New Approach to Controlling Invasive Rodent Populations with CRISPRA New Approach to Controlling Invasive Rodent Populations with CRISPR - Innovative Genomics Institute (IGI)innovativegenomics.org