Zhu, Zhuo & Zhen show that natural selection has shaped the evolution of CTCF binding sites in primates, driving both conservation and innovation in chromatin organization and contributing to human-specific regulatory evolution. 🔗 doi.org/10.1093/molbev/msag167 #societyjournal #evobio
Evolution of CTCF binding sites in the human genomeAbstract. The CCCTC-binding factor (CTCF) is a master regulator of topologically associating domains (TADs), which shape 3D genome architecture and gene redoi.org