Professor at Harvard Medical School, in love with a red-haired beautiful woman, his kids... and immunology. He/him/his. 🇮🇹 🇺🇸 Views my own.
Lot of fun participating to this important initiative @ImmunologyAAI! Lot of passionate attendees/trainees, that asked lot of interesting questions… #Immunology is def in good hands!
The American Association of ImmunologistsIn his lecture on “Molecular and Cellular Regulation of Inflammation,” Ivan Zanoni (Harvard Medical School / Boston Children’s Hospital) explained how phagocytes detect virulence factor activity to kickstart inflammation. #AAIcourses
Had so much fun writing this commentary for #msphere! Grateful for the opportunity to write about work that’s shaped my perspective on innate immunity and RNA virus infection journals.asm.org/doi/10.1128/...
mSphere of Influence: Damage in RNA virus infection—a feature or a bug? | mSphereHow does the body recognize viral infection? How do viruses engage the immune system
during replication? These seemingly simple questions led me to study pattern recognition,
a concept first proposed ...journals.asm.org#WeekendRead! #EveryCellIsAnImmuneCell! Jacobs, Bergers &co show @cp-immunity.bsky.social that high endothelial venules #HEVs utilize #autophagy to maintain their identity & recruit immune cells to secondary lymphoid organs during inflammation. Inhibiting autophagy in HEVs protects from #psoriasis!
Autophagy maintains high endothelial venule identity and function during inflammationHigh endothelial venules (HEVs) facilitate lymphocyte entry into lymph nodes by displaying
peripheral node addressin (PNAd), yet how PNAd is regulated remains poorly understood.
Jacobs et al. reveal t...www.cell.comHighly recommend 👇👇👇
Iannacone Lab🔬 Recruiting a Physician Scientist PhD student (San Raffaele, Milan) via AIRC-Cariplo-SEMM-UniMi program. Project: reprogramming tumor endothelium to restore anti-tumor immunity in liver cancer. Keep 20% clinical work. Deadline Sept 16. Apply: tinyurl.com/3vcp27dp #AIRC
Delighted to share an invited review from @labwaggoner.bsky.social written with Anusha Anukanth (Now @upmc.com) in @jimmunol.bsky.social We explore the plethora of functions ascribed to NK cells and what this means for health, disease, and therapy academic.oup.com/jimmunol/art...
#WeekendRead! #LiveForever! Tan, Andreasson &co show @science.org that PGE2 signaling via EP2 in aged tissue resident macrophages prevents neutrophil efferocytosis driving NETs, stromal cell signaling, & inflammaging! Targeting EP2 delays organ aging! doi.org/10.1126/science.aea3075
Restored clearance of senescent neutrophils by tissue-resident macrophages limits organ agingAging disrupts tissue homeostasis across organ systems. Here, we identify tissue-resident macrophages (TRMs) as central coordinators of age-related organ decline through impaired clearance of senescen...doi.orgCheck this out 👇👇👇 Amazing work @cp-immunity.bsky.social by Stephanie, @jkagan1.bsky.social, &co 👇👇👇
Jonathan KaganA new PAMP, a new innate immunity principle and a new preclinical application. I am so pleased to share our study on STING activation mechanisms in health and disease. Led by the fantastic Stephanie Ragland, follow the link below for a summary of all we learned. www.cell.com/immunity/ful...
A query: cGAS, STING, AIM2, NODs, NLRs, RLRs: All these PRRs are categorized as pathogen sensors, because they reside in the cytoplasm. In contrast, TLRs sense non-pathogens and pathogens. How confirmed is this dogma, beyond the usual (small) set of pathogens that we all study?
Online now: Nasal immunity in respiratory viral infection, transmission, and protection
Nasal immunity in respiratory viral infection, transmission, and protectionThe nasal mucosa is a key decision point during respiratory viral infection. Here, Kazer et al. review new understanding of how local host cell subsets respond during viral infection and how this knowledge may enable tissue-scale protection through mucosal vaccines.dlvr.it
#WeekendRead #EveryCellIsAnImmuneCell #Ironman! Liu, Sun &co show @cellcellpress that #allergens activate PAR1 on lung epithelial cells, elevating intracell levels of iron, leading to protease-independent GSDMD cleavage & release of pro-allergic IL33 & ILC2 activation! www.cell.com/cell/abstrac...
Iron drives protease-independent cleavage of gasdermin D in allergic airway diseasesAllergen exposure activates gasdermin D in lung epithelial cells through an iron-mediated,
protease-independent mechanism requiring the PAR1-ferritinophagy-PCBP2 axis. This
unconventional cleavage dri...www.cell.com
#JoinUs & present your #science!! Exciting #free satellite meeting just after #Cytokines2026 @cytokinesociety.bsky.social 👇👇👇
Achille Broggi🧪👨🏼🔬🔬Which is the best #IFN, and why is it IFN-λ? If you are also interested in this amazing #cytokine, and you're planning to attend the @cytokinesociety.bsky.social meeting in Glasgow this fall, we have you covered with a #free satellite workshop on the 22nd of october. ifnlworkshop.org
Excited to share this “Insight” @jem.org about an amazing new finding by Zhou, Zhang, Ye, Staeheli &co showing that type III interferons #IFNL also signal in #fibroblasts driving renal #fibrosis! #InterferonPower! #EveryCellIsAnImmuneCell! #FriendsOrFoes!
Journal of Experimental MedicineIFNλ works at mucosal surfaces by signaling in epithelial cells and selected immune cells. Zhou, Zhang et al. (rupress.org/jem/article/...) demonstrate that IFNλ also signals in kidney fibroblasts sustaining renal #fibrosis. @lozanzi.bsky.social highlights the findings: rupress.org/jem/article/...
#WeekendRead! #DoNotStress! #EveryCellIsAnImmuneCell! Bashir Zeng &co show @cp-cancercell.bsky.social that gut leakage due to chronic stress-induced steroids leads to translocation of an enterococcus to tumors, driving corticosterone by cancer-associated fibroblasts to inhibit anti-tumor B cells!
Chronic stress unleashes an intratumor phage-fibroblast-B cell circuit to promote tumor growthChronic stress disrupts the gut microbiota in patients with cancer; however, how stress-induced microbiota perturbations impact anti-tumor immunity re…www.sciencedirect.com#WeekendRead! #MomIsAlwaysMom! Fan Zheng Chen &co show @science.org that a maternal diet-derived fatty acid contained in breast milk potentiates Th1 responses in newborns protecting against bacteria & viruses throughout adulthood! doi.org/10.1126/scie...
Maternal trans-vaccenic acid shapes neonatal T cell development and early-life immune imprintingHow maternal nutrition influences neonatal immune development and imprinting through breastfeeding remains largely unclear. We report that maternal supplementation with trans-vaccenic acid (TVA), the ...doi.org
Would love to see fellow #IFNL enthusiasts in Scotland🏴 in October! Abstract submission is due early July and is separate from #Cytokines2026. 1 day free add on so register and submit an abstract soon 👇👇👇 Thanks @achillebro.bsky.social Rune and Charlotte for the talk invitation 😀 #BestIFN
Achille Broggi🧪👨🏼🔬🔬Which is the best #IFN, and why is it IFN-λ? If you are also interested in this amazing #cytokine, and you're planning to attend the @cytokinesociety.bsky.social meeting in Glasgow this fall, we have you covered with a #free satellite workshop on the 22nd of october. ifnlworkshop.org