Antibody–drug conjugates in solid tumors: Efficacy, challenges, and opportunities. New review from Nakul M. Shah and Funda Meric-Bernstam @mdanderson.bsky.social: rupress.org/jem/article/... #SolidTumors
Профиль
Journal of Experimental Medicine
Профиль VivelyJournal of Experimental Medicine publishes immunology, cancer, stem cells, microbial pathogenesis, vascular biology, and neurobiology research. Published by Rockefeller University Press @rupress.org 🌐 rupress.org/jem
New content is available in our journal-based #CME activities: 📄 “Familial pulmonary alveolar proteinosis and type I interferonopathy by mutation of STAT2 (TIMS2)” from Gruber et al. @bogunoviclab.bsky.social doi.org/10.1084/jem.... Begin the activity 👉 mskcc.cloud-cme.com/course/cours...
A nerve and #mastcell sentinel system releases extracellular condensates to induce #macrophage repair. New study from Lilian Salm, Monica Aida Lopez, Paul Kubes (@ucalgary.bsky.social @queensuresearch.bsky.social) and colleagues: rupress.org/jem/article/... #Neuroimmunology #InnateImmunity
Beyond barrier immunity: IL-17 safeguards the renal epithelium. Michail S. Lionakis @niaidnews.bsky.social discusses new work by Choi et al. of the Biswas lab (rupress.org/jem/article/...) in Insights: rupress.org/jem/article/... #InnateImmunity #inflammation #InfectiousDisease #HostDefense
Tissue-type plasminogen activator protects against kidney damage in invasive fungal infection. New study from Wonseok Choi, Partha S. Biswas @pittdeptofmed.bsky.social and colleagues: rupress.org/jem/article/... #InnateImmunity #inflammation #InfectiousDisease #HostDefense
Nakul M. Shah and Funda Meric-Bernstam review the rapidly evolving landscape of antibody–drug conjugates for #SolidTumors. The authors evaluate major design components, clinical efficacy of approved agents, and determinants of response and resistance. rupress.org/jem/article/...
“Very much appreciated being part of such an efficient and productive review process.” — Arielle Klepper, University of California, San Francisco (@ucsanfrancisco.bsky.social). Receive clear and constructive guidance on your next manuscript. 👉 hubs.la/Q048G2510
Familial pulmonary alveolar proteinosis and type I #interferonopathy by mutation of #STAT2 (TIMS2). New study from Conor Gruber, Dusan Bogunovic @bogunoviclab.bsky.social @columbiamed.bsky.social and colleagues: rupress.org/jem/article/... #HumanDiseaseGenetics #Immunodeficiency #InnateImmunity
Salm, Lopez, Kubes et al. reveal that peritoneal #mastcells, activated by sensory neurons, extend #cytonemes that hand off extracellular condensate to neighboring #macrophages, driving rapid aggregation & a repair phenotype. rupress.org/jem/article/... #Neuroimmunology #InnateImmunity #inflammation
JEM is pleased to present opportunities to engage in #CME @MSKCME. The latest activity is now available 👉 mskcc.cloud-cme.com/course/cours... 📄 New content: “Familial pulmonary alveolar proteinosis and type I interferonopathy by mutation of STAT2 (TIMS2)” (Gruber et al. doi.org/10.1084/jem....)
Insights: Choi et al. (rupress.org/jem/article/...) identify a downstream tPA–LRP1 axis that safeguards the renal epithelium during systemic #candidiasis, revealing a mechanism by which IL-17 preserves organ integrity. Michail Lionakis highlights the findings: rupress.org/jem/article/...
Wonseok Choi, Partha S. Biswas et al. show that tissue-type plasminogen activator protects against kidney damage, thereby highlighting a previously unrecognized tissue-protective signaling pathway that mitigates organ damage during #candidiasis. rupress.org/jem/article/...
ICYMI: this collection covers a range of topics including aleveolar macrophage differentiation and function, fibroblast diversity in GALT, MAIT (dys)function after neonate antibiotic use, ILC3 homeostasis, gut immune tolerance by RORγt+ regulatory T cells, and more 🔎 : 👉 rupress.org/jem/collecti...
Humans homozygous for rare or common hypomorphic IL23R variants are prone to #tuberculosis. From Diana Olguín Calderón, Laura E. Kilpatrick, Clément Conil, Quentin Philippot, Jean-Laurent Casanova @casanovalab.bsky.social, Stéphanie Boisson-Dupuis and colleagues: rupress.org/jem/article/...
Gruber, @bogunoviclab.bsky.social et al. identify #STAT2 mutations in a family with severe early-onset pulmonary alveolar proteinosis (PAP), a rare lung disease marked by alveolar surfactant accumulation. rupress.org/jem/article/...
#Inflammation rewires the enteric nervous system through neurogenic #monocyte recruitment. From Sravya Kurapati, Changsik Shin, Krisztina Szabo, Milena Bogunovic and colleagues: rupress.org/jem/article/... 📘 Part of our #Mucosal #Immunology collection: 👉 rupress.org/jem/collecti... #ICMI2026
✍️💻 Our latest #CME activity @mskcme.bsky.social is now available! New content 📄: “Familial pulmonary alveolar proteinosis and type I interferonopathy by mutation of STAT2 (TIMS2)” (Gruber et al. doi.org/10.1084/jem....) Begin the CME here 👉 mskcc.cloud-cme.com/course/cours...
ADAR1 loss-of-function variants altering RNA editing define a new #interferon-dependent #psoriasis subtype. New study from Florence Assan, Hervé Bachelez @institutimagine.bsky.social and colleagues: rupress.org/jem/article/... #HumanDiseaseGenetics
Nasal germinal centers and IgA class switch recombination depend on CCR6 and B cell receptor affinity. From Jingjing Liu, Liat Stoler-Barak, and @zivshulman.bsky.social: rupress.org/jem/article/... 📘 Part of our #Mucosal #Immunology collection: 👉 rupress.org/jem/collecti... #ICMI2026
🔬 From our July issue: rupress.org/jem/issue/22... Image shows Oil Red O staining of lung and bronchoalveolar lavage (BAL) cytospin cells. From Mínguez-Martínez et al. (doi.org/10.1084/jem....).