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☀️🔥 New RNA-modification newsletter, heat-wave edition: wobble mods, QueC evolution, tRNA thiolation, host signals rewiring virulence translation, bacterial mRNA fate, and a bonus chapter on ribosome heterogeneity, hibernation & dormancy. 🦠 Stay cool, modify your RNAs.

☀️🔥🏜️ RNA Modifications Newsletter - June-July 2026Issue #12rnamodifupdates.substack.com

NTU's School of Biological Sciences is hiring faculty, Assistant Professor to Full Professor. The environment is collaborative and the start-up funding is genuinely generous. Four research areas. Campus visits 28 Sep to 2 Oct 2026. Apply here www.ntu.edu.sg/sbs/about-us...

Such a fantastic week at #KSBeyondAntibiotics26! Amazing science, timely conversations about AMR & bacterial infections, and AWESOME people. Thanks to my co-organizers and everyone who joined us in beautiful Breckenridge! @dariavantyne.bsky.social @maribyndloss.bsky.social @kimingeneva.bsky.social

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A nice story by Ami Bhatt's lab. A transposable element insertion upstream of a folate transporter formed a strong promoter, increasing transcription and improving relative fitness under folate limitation. We have recently reported that folate biosynthesis www.nature.com/articles/s41...

Transposable elements are driving rapid adaptation of Enterococcus faecium - NatureOver three decades, rapid expansion of the transposable element ISL3 has reshaped Enterococcus faecium, which helps to explain this pathogen’s growing clinical threat.www.nature.com

Here is it! Super new science from us on horizontal gene transfer & bact defense systems! Liyana OW YONG discovered the first-of-its-kind defense factor AbjA that triggers 'abortive conjugation' as a defense mechanism, by targeting the T4SS! How neat?! #MicroSky 1/7 www.biorxiv.org/content/10.6...

Important study by Chris Connor and Ben Howden (both not on here?) @unimelb.edu.au 'Global dissemination of optrA-mediated linezolid resistance in enterococci', major roles of mobile genetic elements in the dissemination of this important resistance determinant academic.oup.com/jac/article/...

Global dissemination of optrA-mediated linezolid resistance in enterococciAbstractObjectives. Acquired resistance to last-line linezolid has emerged in Enterococcus spp. and can be conferred by the optrA gene. Here, we study theacademic.oup.com

Study 2: Culture-enriched metagenomic sequencing reveals within-patient diversity and transmission of vancomycin-resistant Enterococcus faecium www.medrxiv.org/content/10.6...

Culture-enriched metagenomic sequencing reveals within-patient diversity and transmission of vancomycin-resistant Enterococcus faeciumColonization of the gastrointestinal (GI) tract by vancomycin-resistant Enterococcus faecium (VREfm) often precedes bloodstream infection and serves as a reservoir for onward patient transmission in h...www.medrxiv.org

Vancomycin tolerance and dispersion of dual species biofilms of Clostridioides difficile and Vancomycin-resistant Enterococcus faecium https://www.biorxiv.org/content/10.64898/2026.03.09.710618v1

Adaptation of Enterococcus faecalis to intestinal mucus revealed by a human colonic organoid model #mSystems from Alexandre Persat with @kimingeneva.bsky.social journals.asm.org/doi/10.1128/...

Adaptation of Enterococcus faecalis to intestinal mucus revealed by a human colonic organoid model | mSystemsGut microbiota interactions with mucus during early intestinal colonization are critical for establishing stable communities and influencing host health. Using human colonic organoids combined with Tn-seq and live imaging, this study reveals how Enterococcus faecalis adapts to the mucosal surface by forming microcolonies and reprogramming its metabolism. This integrative approach provides a powerful platform to study other microbiota members in the native-like environment of the large intestine and evaluate potential therapeutic interventions.journals.asm.org

⏰ Last chance to save $250! Register for Beyond Antibiotics by 11:59pm MST on March 5. Join @joeyzacks.bsky.social, @kimingeneva.bsky.social, @dariavantyne.bsky.social & @maribyndloss.bsky.social to spark new collaborations. 🎥 youtu.be/8Ppjx-MnvxA keysym.us/KSBeyondAnti... #KSBeyondAntibiotics26

KSQA: Drs. Joseph P. Zackular & Mariana X. Byndloss (Beyond Antibiotics)YouTube video by KeystoneSymposiayoutu.be

🧵 After years out of the field, I and my lab are again working on bacterial type IV pili. We have just posted our first preprints, and I'm excited to share what we have discovered. This shows Neisseria gonorrheae bacteria infecting a human epithelical cell. Here, you can see the pili in red. 1/

The American Academy of Microbiology proudly announces the election of 63 fellows to the Class of 2026. Over the past 50 years, the Academy has elected +2,700 distinguished scientists. This year, the new fellows hail from 14 countries. Read press release: asm.social/2OC

New in JB: Weiss, Tamayo et al. describe a very cool microbial interaction wherein Enterococcus faecalis, an opportunist found in the inflamed gut, impacts phase-variation noted by chaining & rough colony morphology of C. diff. journals.asm.org/doi/10.1128/... @asm.org #JBacteriology

Abstract deadline Mon for 6th Clinical & Scientific Advances in UTI, the premier biennial gathering of our international community. Privileged to be co-organising this year. See you in Nashville! utiga.org/2026-6th-csa... #UTI #UTISky #IDSky #MicroSky @globaluti.bsky.social utiga.org/2026-6th-csa...

Scientist's way of saying 'I ❤️ you' "I found this paper/preprint that made me think of your project." "I checked the mice/cells/plates already." "I just sent you the edits you requested." "I have a slide/diagram that will work for that." "I had that problem with [lab equipment], I have a fix."

🎉 New paper out! Taking a closer look at Enterococcus thailandicus, a species long considered of low clinical relevance. doi.org/10.1016/j.nm...

⏰ Deadline Jan 7 (11:59 pm MST) to submit a short talk abstract or apply for a scholarship for the Keystone Symposium Beyond Antibiotics. Hear from @joeyzacks.bsky.social, @maribyndloss.bsky.social: youtu.be/8Ppjx-MnvxA keysym.us/KSBeyondAnti... @kimingeneva.bsky.social & @dariavantyne.bsky.social

KSQA: Drs. Joseph P. Zackular & Mariana X. Byndloss (Beyond Antibiotics)YouTube video by KeystoneSymposiayoutu.be

'In 2021, 11,021 deaths and 353,634 DALYs were attributable to VREfm worldwide, (...) 2,991 deaths and 82,025 DALYs attributable to VREfs. (...) VREfm burden is projected to continue rising across all indicators by 2050, while VREfs shows a sustained decline.' www.sciencedirect.com/science/arti...

Global burden, inequalities and projections of vancomycin-resistant Enterococcus faecium and Enterococcus faecalis, 1990–2050: a systematic global analysisVancomycin-resistant Enterococcus faecium (VREfm) and Enterococcus faecalis (VREfs) are major antimicrobial resistance threats. Previous assessments r…www.sciencedirect.com

Thrilled to share that neutrophils produce extra long fibrillar components named proteoglycofili or PGF. PGF are released by living neutrophils and do not contain DNA. They might look like NETs but are not NETs… www.cell.com/cell-reports...

Proteoglycofili are glycosaminoglycan-containing fibrillar components released by neutrophils to neutralize bacteriaAlternative to the formation of NETs, André et al. describe here that viable neutrophils may release a fibrillar component named proteoglycofili or PGF upon stimulation. PGF formation is associated wi...www.cell.com