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🚨Join us at the University of Geneva! We're seeking an outstanding junior researcher to apply for an ERC or SNSF Starting Grant with our institutional support in host–pathogen interactions, bacteriology, virology, parasitology, or mycology. www.unige.ch/medecine/mim... Please share!

We've been learning a lot about how Enterococcus faecalis interacts with neutrophils lately. In our latest preprint, @harisantypas.bsky.social describes how lactic acid from E. faecalis dampens neutrophil metabolism leading to NETosis and phagoytosis suppression. #microsky

Frederick's @frederickreinhart.bsky.social paper on E. faecalis egress from host cells following intracellular replication is now up at #PLOS Pathogens. 😎 Check it out! dx.plos.org/10.1371/jour...

Gelatinase regulates the egress of intracellular replicating populations during Enterococcus faecalis infectionAuthor summary Pathogenic bacteria are traditionally classified as either “intracellular” or “extracellular”, but growing evidence suggests that many extracellular bacteria also adopt transient intrac...dx.plos.org

What if quorum sensing doesn’t promote biofilms - but restrains it? 🤔 New work from @harisantypas.bsky.social shows that the Fsr QS system in Enterococcus faecalis acts as a brake on biofilm formation and pathogenesis during infective endocarditis (IE). www.nature.com/articles/s41...

Loss of Fsr quorum sensing promotes biofilm formation and worsens outcomes in enterococcal infective endocarditis - Nature CommunicationsInfective endocarditis (IE) is an understudied biofilm-associated infection. Here, analyses of preclinical and clinical data reveal that the Fsr quorum sensing (QS) system of Enterococcus faecalis is ...www.nature.com

Lactic acid lover? Check out @ronni.bsky.social 's new work in @cp-cellhostmicrobe.bsky.social showing how Enterococcus faecalis-derived LA suppresses macrophage activation, in turn promoting bacterial persistence and polymicrobial wound infection in vivo. www.sciencedirect.com/science/arti...

Enterococcus faecalis-derived lactic acid suppresses macrophage activation to facilitate persistent and polymicrobial wound infectionsMacrophage activation is essential for innate immunity and antimicrobial defense. We show that Enterococcus faecalis suppresses macrophage activation …www.sciencedirect.com

Strep/Enterococcal colleagues! Streptococcal Biology GRC/GRS are open for applications. Acceptances are underway and the meeting is on track to fill up. If you’re aiming for a short talk (lots of slots), registering early matters for full consideration. Share widely! www.grc.org/streptococca...

Enterococcus fans: Check out our latest on E. faecalis EET, advancing our understanding of both the fundamental physiology of this bug and new mechanisms of its virulence. This is the product of a thrilling collaboration with friends in Singapore @gthibault.bsky.social led by @aarontan.bsky.social.

🧵Enterococcus faecalis is not just an extracellular organism. 🧵 A growing body of work shows it can survive + REPLICATE inside host cells, and that intracellular life may seed persistence, dissemination, and reinfection. 1/n #MMBR @asm.org journals.asm.org/doi/10.1128/...

Enterococcus faecalis: an overlooked cell invader | Microbiology and Molecular Biology ReviewsSUMMARYEnterococcus faecalis and Enterococcus faecium are human pathobionts that exhibit a dual lifestyle as commensal and pathogenic bacteria. The pathogenic lifestyle is associated with specific conditions involving host susceptibility and intestinal ...journals.asm.org

🤩 Long ago in 2021, Irina Afonina saw E. faecalis prophage tail fibers co-purify with membrane vesicles, but we didn't know their fxn: pmc.ncbi.nlm.nih.gov/articles/PMC.... In this new preprint, Mike Gilmore and colleagues show us what the tail fibers (aka efagins) actually do! Super cool work. 🤩

The composition and function of Enterococcus faecalis membrane vesiclesMembrane vesicles (MVs) contribute to various biological processes in bacteria, including virulence factor delivery, antimicrobial resistance, host immune evasion and cross-species communication. MVs are frequently released from the surface of both ...pmc.ncbi.nlm.nih.gov

Excited to share our first look at Enterococcus faecium infection biology: diabetic wounds are complex, and E. faecium persists despite early immune responses. In diabetic mice, it shows impaired clearance + sustained neutrophil recruitment, worsening healing.

Why does daptomycin resistance appear so fast in Enterococcus? We finally have a clue. DAP resistance in enterococci pops up quickly. What’s been missing is why resistance-associated membrane changes look the way they do, and why the classic path of mutations is so predictable.

We're just 6 months away from @keystoneSymposia.bsky.social Beyond #Antibiotics : Emerging Strategies Combating #BacterialInfection, May 2026 in Breckenridge! 👉Scholarship and short talk abstract deadlines are Jan 7! 🧐 keysym.us/KSBeyondAntibiotics26 #KSBeyondAntibiotics26

Beyond Antibiotics: Emerging Strategies for Combating Bacterial Infection | Keystone SymposiaJoin us at the Keystone Symposia on Beyond Antibiotics: Emerging Strategies for Combating Bacterial Infection, May 2026, in Breckenridge, with field leaders!keysym.us

💕 Such a joyful day celebrating the wedding of our longest-standing lab member Pei Yi (since 2012!) and former PhD student Kelvin. 💍 Their special day brought together generations of the Kline Lab family - a wonderful reminder of the friendships and community that science builds along the way. 💕