Профиль

Our ProteinGuide paper is finally out! Thanks to all the co-authors @junhaobearxiong.bsky.social, @ishangaur.bsky.social, @hnisonoff.bsky.social, @loltrogge.bsky.social, @jlistgarten.bsky.social, @savagecatsonly.bsky.social! @innovativegenomics.bsky.social www.nature.com/articles/s41...

Property guidance for protein sequence generative models with ProteinGuide - Nature BiotechnologyOn-the-fly conditioning of pretrained protein generative models guides protein generation toward specific properties.www.nature.com

Our new paper on Y-linked CRISPR editors for invasive rodent control is featured by @innovativegenomics.bsky.social. innovativegenomics.org/news/a-new-a... #CRISPR #RodentControl

A New Approach to Controlling Invasive Rodent Populations with CRISPRA New Approach to Controlling Invasive Rodent Populations with CRISPR - Innovative Genomics Institute (IGI)innovativegenomics.org

Scientists have harnessed AI models to create synthetic CRISPR proteins that edit the genome more efficiently than those seen in nature go.nature.com/4f8AN3n

CRISPR gets a power boost from AI-designed ‘molecular scissors’Researchers used artificial intelligence to design functional CRISPR enzymes not seen in nature.go.nature.com

I’m happy to share our pre-print exploring the activity and specificity trade-offs in adenine base editors. Thanks to my amazing co-authors Luke Oltrogge, @hnisonoff.bsky.social, and all the other contributors @jlistgarten.bsky.social @savagecatsonly.bsky.social @innovativegenomics.bsky.social 🧵1/7

Activity and specificity trade-offs in adenine base editorsAdenine base editors (ABEs) are CRISPR effectors that introduce A-T to G-C transitions in the genome using a nucleotide deaminase fused to a Cas protein. ABEs have been evolved to have very high editi...www.biorxiv.org

So excited to see our paper out in Science! Beyond grateful to my co-leads @petrskopintsev.bsky.social @evandeturk.bsky.social, all co-authors & collaborators, everyone in Doudna lab, and @innovativegenomics.bsky.social Being EsAIn in the DouDNA lab, it couldn't have been any other way ✨

🎧 Listening tip! Jennifer Doudna, Nobel laureate and #CRISPR co‑developer, discusses how #GenomeEditing supports the development of more resilient and nutritious crops, while also promoting broad access & public dialogue 🌱 https://ow.ly/Yb3v50ZjZ24

What’s the Future of Gene Editing? | Quanta MagazineIn the first episode of the new season of ‘The Joy of Why,’ Nobel Laureate Jennifer Doudna discusses how she discovered CRISPR’s genome-editing power, the breakthroughs and hurdles during its explosive growth, and what lies ahead for this groundbreaking technology.ow.ly

Huge congratulations to Doudna Lab postdoc, Santiago!

"In […] ‘The Joy of Why,’ Nobel Laureate Jennifer Doudna discusses how she discovered CRISPR’s genome-editing power, the breakthroughs and hurdles during its explosive growth, and what lies ahead for this groundbreaking technology." #Conversations #CRISPR #GeneEditing #JenniferDoudna

What’s the Future of Gene Editing? | Quanta MagazineIn the first episode of the new season of ‘The Joy of Why,’ Nobel Laureate Jennifer Doudna discusses how she discovered CRISPR’s genome-editing power, the breakthroughs and hurdles during its explosiv...www.quantamagazine.org

“The Joy of Why” is back. In our first episode of the new season, pioneering biochemist Jennifer Doudna talks about how her early, “rebellious,” decision to study RNA led her to a Nobel Prize. Tune in: podcasts.apple.com/us/podcast/w...

What’s the Future of Gene Editing?Podcast Episode · The Joy of Why · June 11 · 51mpodcasts.apple.com

CRISPR is commonly thought of as a repair tool for the genome. This clever new approach to fighting some of the most challenging cancers takes CRISPR back to its roots in nature, using it to seek and selectively destroy cells with a cancer signature. 🧬🧪

#CRISPR enzyme precisely detects and shreds #DNA in #cancer mutations once considered 'undruggable' #Chemistry #Health #Science #Technology

CRISPR enzyme precisely detects and shreds DNA in cancer mutations once considered 'undruggable'In 2020, Jennifer Doudna won the Nobel Prize in chemistry for her work on the CRISPR-Cas9 gene-editing technology that allows scientists to precisely modify DNA by cutting it at specific locations. Si...medicalxpress.com

The Nobel Prize winning CRISPR technology was applied to treating a patient with sickle cell anemia. Jennifer Doudna, pictured here, shared the Nobel Prize (2020) with Emmanuelle Charpentier for CRISPR. A reminder that work on CRISPR was supported by #NIH funding. 🧪

Видео

Super excited to share the final project of my postdoc career! We found that Borgs and mini-Borgs are widespread across diverse ecosystems. They don't just exist in Banfield Lab — they are everywhere! 🌎

🎙️ON AIR: We're talking to @innovativegenomics.bsky.social's @urnov.bsky.social and science writers @philipcball.bsky.social and @michael-marshall.bsky.social about how sequencing the human genome changed our understanding of life. ❓What are your questions about DNA mapping? 📻 Listen:

What Did Mapping The Genome Get Us? | KQEDWe look back at J. Craig Venter’s scientific contributions and consider whether our expectations for the medical and scientific transformations from DNA mapping have been realized.buff.ly

Our lab is proud to present our latest work harnessing Bridge Recombinase for genome-scale editing in diverse bacteria, microbiome editing, and programmable horizontal gene transfer.

We present VIPR, a phage-encoded RNA-guided system that recognizes DNA with a noncontiguous code unlike CRISPR. Tiny, programmable, possibly ancestral to CRISPR immunity; VIPR is built around a striking RNA-DNA-DNA triplex.

It's #CancerControlMonth. 🧪 UCSF and Innovative Genomics Institute group develops in-vivo, site-specific engineering approach to reprogram T cells, providing a pathway for more efficient, precise, & widely accessible T-cell therapies. Charlotte H. Wang, Jennifer Doudna, Justin Eyquem

In vivo site-specific engineering to reprogram T cells | NatureEngineered T cells, reprogrammed to express chimeric antigen receptors (CAR) or T cell receptors (TCR), have transformed cancer treatment and are being explored as therapeutics for autoimmune and infectious diseases. Enhancing T cell function through genome editing, either by disrupting endogenous genes or precisely inserting DNA payloads, has shown considerable promise1. However, the ex vivo manufacturing process is lengthy and costly, limiting accessibility of these therapies. In vivo generation of CAR T cells could overcome these barriers, but current methods rely either on...www.nature.com