PostDoc @Doudna_lab 🧬| PhD @Cambridge_Uni | @Harvard @imperialcollege - I like epigenetics and editing genes. Life begins at the end of your comfort zone✨✈️🌍⛵️🎿
So excited to see our latest work out!
Science MagazineIn a new Science study, researchers report the design of synthetic RNA-guided nucleases that match or exceed the activity of natural enzymes, revealing how structure-guided design can generate functional genome-editing proteins with substantially different sequences. https://scim.ag/45fbSFf
Thanks to @nature.com and @scattercushion.bsky.social for featuring our latest work published in @science.org!
NatureScientists have harnessed AI models to create synthetic CRISPR proteins that edit the genome more efficiently than those seen in nature go.nature.com/4f8AN3n
So excited to see our paper out in Science! Beyond grateful to my co-leads @petrskopintsev.bsky.social @evandeturk.bsky.social, all co-authors & collaborators, everyone in Doudna lab, and @innovativegenomics.bsky.social Being EsAIn in the DouDNA lab, it couldn't have been any other way ✨
Doudna LabOur AI-guided design of RNA-guided nucleases is now out in @science.org 💻🧬 We used structure and evolutionary data to generate minimal, active and divergent gene editors! www.science.org/doi/10.1126/... Congrats to @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social & team!
Synthetic microbiomics 🙌 Genome-scale editing with bridge recombinases - Congrats to @jayman1466.bsky.social @sophswartz.bsky.social, Agnes & team!
Cress LabOur lab is proud to present our latest work harnessing Bridge Recombinase for genome-scale editing in diverse bacteria, microbiome editing, and programmable horizontal gene transfer.
An RNA-guided system that recognizes a noncontiguous DNA code? 🤯 Check out the latest work from the Doudna Lab on the discovery of VIPR. Really exciting biology!
Doudna LabWe present VIPR, a phage-encoded RNA-guided system that recognizes DNA with a noncontiguous code unlike CRISPR. Tiny, programmable, possibly ancestral to CRISPR immunity; VIPR is built around a striking RNA-DNA-DNA triplex.
First co-led work from the Doudna lab 🤜🤛 We designed minimal RNA-guided nucleases with AI, and even did Cryo-EM during an earthquake (!) Huge honor working with @petrskopintsev.bsky.social, @evandeturk.bsky.social, Jennifer Doudna and co-authors, everyone at D-Lab and @innovativegenomics.bsky.social
Doudna Lab✨New preprint! 🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al! Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬 🔗👇
Incredible work by @owentuck.bsky.social, Jason Hu et al 👏🏼 Antiviral systems repeatedly acquire nuclease–protease pairs to fight viruses ⚔️
Innovative Genomics InstituteNew in Science Magazine from the Doudna Lab and first author Owen Tuck: Recurrent acquisition of nuclease-protease pairs in antiviral immunity. Read here: https://ow.ly/pIWQ50XtEtM
Super cool work by @erinedoherty.bsky.social and @jnoms.bsky.social ! 💪🏼 Viruses hack bacterial immunity by breaking down the nucleotide signals that trigger defence 🦠🧬
Erin DohertyWork I co-led with @jnoms.bsky.social is now online at @cp-cellhostmicrobe.bsky.social ! We revealed a previously unrealized diversity of viral immune-evasion proteins that selectively destroy different cyclic nucleotide signals used in bacterial immunity. www.sciencedirect.com/science/arti...
So honored to receive the Best Thesis Prize❤️ @cambridgeuni.bsky.social @cruk-ci.bsky.social still feels surreal. Thank you to CRUK, my supervisors for believing in my ideas, and my former lab members, friends and family for always supporting me. So grateful to be part of such an inspiring community!
Cancer Research UK Cambridge InstituteCongratulations to @isabelesain.bsky.social, who is awarded the 2024 CRUK Cambridge Institute PhD Thesis Prize. In her doctoral research, Bel discovered a new molecular mechanism in cancer gene regulation opening up a new therapeutic window for cancer treatments. www.cruk.cam.ac.uk/news/bel-esa...