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Very happy to share our new article published @ChemBioChem on enzymatic GalNAc-labelling of oligonucleotides. Big congrats to @pierrenicolasbizat.bsky.social and all authors! @ipdbsc.bsky.social @pasteur.fr @cnrs.fr @chem4life.bsky.social chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

Thrilled to share our recent pre-print where we studied the stereochemical outcome of phosphorothioate bond formation during ligation. Congratulations to Erwann and Nazarii. Great collaboration with Roche. @pasteur.fr @chem4life.bsky.social @cnrs.fr @ipdbsc.bsky.social chemrxiv.org/doi/full/10....

Notre équipe était aux Journées Francophones de Virologie : poster pour Sacha Frick et Lucas Facchinetti, présentation orale pour @emilie-giraud.bsky.social. Bravo à eux ! Merci aux organisateurs pour ce beau congrès. #Virologie #JFV2026 @pasteur.fr @chem4life.bsky.social @ipdbsc.bsky.social

Very happy to share our recent article on the synthesis of Ru-complex modified DNA by SPAAC together with @gassergroup.bsky.social Congrats to all authors! @ipdbsc.bsky.social @chem4life.bsky.social @pierrenicolasbizat.bsky.social chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

Incorporation of Ruthenium Polypyridyl Complexes Into DNA Oligonucleotides by Copper‐Free Click ChemistryAlternative methods for the preparation of naïve libraries for SELEX experiments are in dire need, particularly when hydrophobic, bulky, and complex modification patterns are considered. Here, we exp...chemistry-europe.onlinelibrary.wiley.com

Our PhD student Syrine presented her work at the "Assises de Génétique Humaine et Médicale" in Cannes. Bravo to her for a great poster! @pasteur.fr @ipdbsc.bsky.social @chem4life.bsky.social #PhDLife #Genetics #HumanGenetics #Research #InstitutPasteur #ScientificConference

Very happy to share our new preprint on the selection of COT-modified aptamers. Great work by undergraduate student Charlotte. Congrats to all! chemrxiv.org/engage/chemr... Stay tuned for the published version. @pasteur.fr @chem4life.bsky.social @hollensteinlab.bsky.social @chemrxiv.bsky.social

Probing three-dimensional cyclooctatetraene as nucleobase modification in aptamer selectionDecoration of aptamers with chemical modifications at the level of nucleobases grants access to alternative binding modes which often result in improved binding properties. Most functional groups invo...chemrxiv.org

Avec Jeanne, nous avons présenté un poster aux Journées départementales de BSC. @pasteur.fr @chem4life.bsky.social @ipdbsc.bsky.social #congresscientifique #institutpasteur

Dear all, The next thematic meeting day from SCT will take place at Institut Pasteur Of Lille, France, on June 3rd ! Registration : www.sct-asso.fr/form.php?lan... Abstract submission : www.sct-asso.fr/form.php?lan...

Thrilled to share our article published @chemsocrev.bsky.social on sugar modified nucleic acids. Congrats to Debashis! Great collaboration with Laurence Mulard. @pasteur.fr @ipdbsc.bsky.social @chem4life.bsky.social @cnrs.fr pubs.rsc.org/en/content/a...

Natural, modified and conjugated carbohydrates in nucleic acidsStorage of genetic information in DNA occurs through a unique ordering of canonical base pairs. However, this would not be possible in the absence of the sugar–phosphate backbone which is essential fo...pubs.rsc.org

Dear all, The Department of Structural Biology and Chemistry is pleased to invite you to the Half-Day of Drug Discovery this Tuesday, March 4th, at 1:30 PM in the Auditorium François Jacob. Program details : research.pasteur.fr/fr/event/hal... #InstitutPasteur #DBSC #Chem4Life #CNRS #DrugDiscovery

HALF-DAY DRUG DISCOVERY, Department of Structural Biology and Chemistry - ResearchInstitut Pasteur, ParisAuditorium François JacobMarch 4, 2025 PROGRAM 13:30 OPENING 13:40 Suzanne PEYROTTES (IBMM, Montpellier) “Discovery of an AcycloNucleoside Phosphonate (ANP) as potent inhibitor ...research.pasteur.fr

I am very happy to share my first publication. ✨ Our review with @hollensteinlab.bsky.social and Nazarii Sabat on biocatalytic approaches for the synthesis of oligonucleotides. 🧬 @pasteur.fr @chem4life.bsky.social chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

Recent advances in biocatalytic and chemoenzymatic synthesis of oligonucleotidesAccess to synthetic oligonucleotides is crucial for applications in diagnostics, therapeutics, synthetic biology, and nanotechnology. Traditional solid phase synthesis is limited by sequence length a...chemistry-europe.onlinelibrary.wiley.com

Congratulations !

The Structural Biology and Chemistry Department at Institut Pasteur is seeking a junior or mid-career researcher to lead a new group in Medicinal Chemistry, Chemical Biology or Structural Biology research.pasteur.fr/en/call/call...

Call for applications 2025 - Creation of new research groups at the Institut Pasteur - ResearchThe Institut Pasteur launches an international call to recruit new junior research group leaders in the application of cutting-edge transdisciplinary approaches to the exploration of host-microbe, tis...research.pasteur.fr