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Very happy to share a preprint on our contribution to identifying a polymerase capable of accepting heavily modified nucleotides. Great collaboration with Marc Delarue and John Chaput. Congrats to Maria! @pasteur.fr @ipdbsc.bsky.social @chem4life.bsky.social www.biorxiv.org/content/10.6...

Polymerase Evolution Enables Access to Glycosylated Xeno-Nucleic Acids with Expanded Chemical FunctionalityChemical modifications expand the functional repertoire of nucleic acids, but the extent to which complex glycans can be integrated into genetic polymers remains largely unexplored. Glycosylated nucle...www.biorxiv.org

Very happy to share our new article published @ChemBioChem on enzymatic GalNAc-labelling of oligonucleotides. Big congrats to @pierrenicolasbizat.bsky.social and all authors! @ipdbsc.bsky.social @pasteur.fr @cnrs.fr @chem4life.bsky.social chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

Very happy to share our new manuscript in Bioconjugate Chemistr on the enzymatic synthesis of Glyco-DNA Equipped with Oligosaccharides and Charged Monosaccharides. Congrats to Maria and Marc! @ipdbsc.bsky.social @pasteur.fr @cnrs.fr pubs.acs.org/doi/10.1021/... pubs.acs.org/doi/10.1021/...

Enzymatic Synthesis of Glyco-DNA Equipped with Oligosaccharides and Charged MonosaccharidesThe therapeutic and biotechnological utility of synthetic oligonucleotides is constrained by the limited chemical diversity of canonical nucleotides and their susceptibility to nuclease degradation. I...pubs.acs.org

Thrilled to share our recent pre-print where we studied the stereochemical outcome of phosphorothioate bond formation during ligation. Congratulations to Erwann and Nazarii. Great collaboration with Roche. @pasteur.fr @chem4life.bsky.social @cnrs.fr @ipdbsc.bsky.social chemrxiv.org/doi/full/10....

Very happy to share our pre-print on the enzymatic synthesis of DNA equipped with short oligosaccharides. Great collaboration with Marc Delarue and Laurence Mulard. Congrats to Maria Dalla Pozza and Marc! chemrxiv.org/doi/full/10.... @pasteur.fr @ipdbsc.bsky.social @cnrs.fr

Very happy to share our recent article on the synthesis of Ru-complex modified DNA by SPAAC together with @gassergroup.bsky.social Congrats to all authors! @ipdbsc.bsky.social @chem4life.bsky.social @pierrenicolasbizat.bsky.social chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

Incorporation of Ruthenium Polypyridyl Complexes Into DNA Oligonucleotides by Copper‐Free Click ChemistryAlternative methods for the preparation of naïve libraries for SELEX experiments are in dire need, particularly when hydrophobic, bulky, and complex modification patterns are considered. Here, we exp...chemistry-europe.onlinelibrary.wiley.com

Happy to share our review article @cp-trendschem.bsky.social on modified aptamers. Congrats to all authors! @pasteur.fr @ipdbsc.bsky.social @cnrs.fr doi.org/10.1016/j.tr...

Thrilled to share our article @J_A_C_S on the selection of Ru-modified aptamers. 7 years in the making. Congrats to all authors! Great collaboration with @gassergroup.bsky.social pubs.acs.org/doi/full/10.... @pasteur.fr @ipdbsc.bsky.social @cnrs.fr @pierrenicolasbizat.bsky.social

Selection of Ruthenium Polypyridyl Complex-Modified Aptamers for Photodynamic Therapy against Streptococcus PneumoniaPhotodynamic therapy (PDT) harnesses the combination of light, oxygen, and photosensitizers to induce cell death via reactive oxygen species (ROS) formation. Given its intrinsic properties, PDT repres...pubs.acs.org

Interested by 3D modified aptamers? Then check out our recent article by undergraduate student Charlotte and postdoc Usman. nature.com/articles/s4200… @ipdbsc.bsky.social @pasteur.fr @cnrs.fr

Very happy to share our preprint @ChemRxiv on the selection of Ru-modified aptamers. Long in the making. Congrats to all authors. Great collaboration with @gassergroup.bsky.social @pasteur.fr @ipdbsc.bsky.social @cnrs.fr 10.26434/chemrxiv-2025-dd90p

Very much looking forward presenting our research at #biotrans2025 in Basel. Thanks again for the kind invitation!

Very happy to share out new pre-print on the enzymatic GalNAc-labelling of oligonucleotides. Big congrats to undergraduate student Elisa and graduate student @pierrenicolasbizat.bsky.social! chemrxiv.org/engage/chemr... @pasteur.fr @ipdbsc.bsky.social @cnrs.fr

Towards the enzymatic labelling of oligonucleotides with triantennary N-acetyl galactosamineThe inclusion of chemical modifications into oligonucleotides stabilizes their backbones against nuclease mediated degradation and improves their biological activity. Even though cellular, tissue, and...chemrxiv.org

very happy to work with my colleague Bruno Pitard on therapeutic RNAs. We thank @inserm.fr for selecting our project and for the very generous funding! @pasteur.fr @ipdbsc.bsky.social @hollensteinlab.bsky.social

Thrilled to share our article published @chemsocrev.bsky.social on sugar modified nucleic acids. Congrats to Debashis! Great collaboration with Laurence Mulard. @pasteur.fr @ipdbsc.bsky.social @chem4life.bsky.social @cnrs.fr pubs.rsc.org/en/content/a...

Natural, modified and conjugated carbohydrates in nucleic acidsStorage of genetic information in DNA occurs through a unique ordering of canonical base pairs. However, this would not be possible in the absence of the sugar–phosphate backbone which is essential fo...pubs.rsc.org

Fantastic opportunity!

Very happy to share our new preprint on the selection of COT-modified aptamers. Great work by undergraduate student Charlotte. Congrats to all! chemrxiv.org/engage/chemr... Stay tuned for the published version. @pasteur.fr @chem4life.bsky.social @hollensteinlab.bsky.social @chemrxiv.bsky.social

Probing three-dimensional cyclooctatetraene as nucleobase modification in aptamer selectionDecoration of aptamers with chemical modifications at the level of nucleobases grants access to alternative binding modes which often result in improved binding properties. Most functional groups invo...chemrxiv.org

Happy to share a short interview (in french) on the synthesis of RNA oligonucleotides. Thanks to @franceculture.fr and @institutpasteur.bsky.social for the invitation. @hollensteinlab.bsky.social @cnrs.bsky.social @chem4life.bsky.social www.radiofrance.fr/francecultur...

Katalin Karikó, la reine de l'ARNmLes travaux révolutionnaires de la biochimiste Katalin Karikó et du médecin Drew Weissman ont ouvert la voie à l’utilisation thérapeutique de l’ARNm avec un premier cas mondialement reconnu : celui de...www.radiofrance.fr

Thrilled to share our review on biocatalytic methods for the synthesis of (modified) oligonucleotides. Congratulations to Pierre Nicolas and Nazarii! Thank you to Dr. Juan Jin and @rubenragg.bsky.social for their invitation!https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.202400987

Impressive work, 800 nt long oligo obtained SPOS: pubs.rsc.org/en/content/a...

Long oligos: direct chemical synthesis of genes with up to 1728 nucleotidesThe longest oligos that can be chemically synthesized are considered to be 200-mers. Here, we report direct synthesis of an 800-mer green fluorescent protein gene and a 1728-mer Φ29 DNA polymerase gen...pubs.rsc.org