Thrilled to share our recent pre-print where we studied the stereochemical outcome of phosphorothioate bond formation during ligation. Congratulations to Erwann and Nazarii. Great collaboration with Roche. @pasteur.fr @chem4life.bsky.social @cnrs.fr @ipdbsc.bsky.social chemrxiv.org/doi/full/10....
Chemoenzymatic Access to Stereodefined Phosphorothioate Oligonucleotides by Stereoselective DNA Ligation | ChemRxivRecent studies have demonstrated that stereopure oligonucleotide phosphorothioates (PS), with defined configuration, provide significant advantages over stereorandom mixtures in therapeutic oligonucle...chemrxiv.org