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We are looking for a lab manager starting from January 2027, you can find more information on our members page pacesalab.com#members. We are also starting to look into hosting master students starting 2027.

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ICYMI: New Online! Regulation of RNA transcript elongation in metazoans and its relevance to disease

Regulation of RNA transcript elongation in metazoans and its relevance to diseaseNature Reviews Molecular Cell Biology, Published online: 30 July 2026; doi:10.1038/s41580-026-01003-wThis Review discusses how transcript elongation by RNA polymerase II is regulated and how obstacles such as nucleosomes are overcome. Also discussed are the roles of transcription surveillance machineries, which ensure mRNA integrity and suppress spurious transcription, and how elongation defects contribute to diseases.dlvr.it

We are excited to share two preprints reporting a mosquito-specific receptor for chikungunya virus and other alphaviruses! 🤩 www.biorxiv.org/content/10.6... www.biorxiv.org/content/10.6... @harvardmicro.bsky.social @harvardvirology.bsky.social @hhmi-science.bsky.social

Bordeaux, France, has now recorded more days above 40°C in 2026 alone than during the entire 105-year period from 1920 (when observations began) to 2025. This is deeply shocking.

New @talusbio.bsky.social #AI preprint just dropped 🚀 Meet Ptarmigan-1. It predicts which small molecules bind a protein, and which residues they hit, from sequence and 2D chemistry alone. No structures, no docking, no poses. www.biorxiv.org/content/10.6... Time for a 🧵 (1/13)

Structure-free, site-resolved contrastive learning extends small-molecule discovery beyond the reach of structure-based modelingVirtual screening asks which molecules, among an enormous space of drug-like chemistry, are worth synthesizing and testing against a protein target. Most modern methods answer by building and scoring ...www.biorxiv.org

Now out as a perspective in PLOS Biology. Where next for structural bioinformatics? journals.plos.org/plosbiology/...

New work from the Gygi and Cantley labs @harvardcellbio.bsky.social provides a unique structure-based protein kinase specificity atlas across the human proteome. An exciting resource for biological discovery! www.nature.com/articles/s41...

An AI-enabled structural atlas decodes kinase specificity across the human proteome - Nature BiotechnologyPhosphorylation potential and kinase specificity are assigned for the entire human proteome.www.nature.com

Huge congrats to the many authors who over MANY years worked on this (but especially @karaehunt.bsky.social , @trevorbrandt.bsky.social, Karina, @shaharsu.bsky.social and @remenecker.bsky.social. www.nature.com/articles/s41...

Rational design of disordered proteins for sequence–function investigation - NatureGOOSE enables the design and testing of thousands of disordered protein region sequences to reveal distinct sequence-to-function relationships.www.nature.com

Latest preprint on AlphaFold potential and limitations. We look in particular at the addition of ions to models.

À pourvoir, la fonction de président de @inserm.fr (Institut national de la santé et de la recherche médicale) vacante à compter du 31 janvier 2027. Candidatures attendues pour le 30 septembre 2026. #ESR

Come work on exciting AI for biology projects in Paris!! 🇫🇷 Details and application below, deadline sept 1st!