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New Online! Structure and function of the outer kinetochore

Structure and function of the outer kinetochoreNature Reviews Molecular Cell Biology, Published online: 03 August 2026; doi:10.1038/s41580-026-00988-8The kinetochore orchestrates chromosome segregation. The KMN complex, which forms the core of the outer kinetochore binds to microtubules, recruits regulators and functions as a switch for the spindle assembly checkpoint. Recent integrative imaging, biochemical and structural studies have revealed how the KMN assemblies ensure accurate chromosome segregation.dlvr.it

New Online! Structure and function of the centromere and inner kinetochore

Structure and function of the centromere and inner kinetochoreNature Reviews Molecular Cell Biology, Published online: 03 August 2026; doi:10.1038/s41580-026-00989-7The kinetochore is a macromolecular complex that assembles on centromeric chromatin and connects spindle microtubules to the chromosome. This Review discusses recent advances in determining the organization of centromeric chromatin and the complete structure and function of the inner kinetochore, which are crucial for accurate chromosome segregation.dlvr.it

ICYMI: New Online! Exchange dynamics and kinetic control of gene regulation complexes

Exchange dynamics and kinetic control of gene regulation complexesNature Reviews Molecular Cell Biology, Published online: 30 July 2026; doi:10.1038/s41580-026-00991-zRecent evidence reveals how gene expression complexes form transient assemblies that continually exchange their subunits under kinetic control. This Perspective proposes that these dynamics form the basis of RNA processing and gene regulation.dlvr.it

ICYMI: New Online! At high noon, plants apply a condensate sunscreen

At high noon, plants apply a condensate sunscreenNature Reviews Molecular Cell Biology, Published online: 30 July 2026; doi:10.1038/s41580-026-01008-5MBS1 condensates induced by high light conditions shield chloroplasts and prevent accumulation of singlet oxygen, thereby conferring tolerance without reduction in photosynthesis.dlvr.it

ICYMI: New Online! Regulation of RNA transcript elongation in metazoans and its relevance to disease

Regulation of RNA transcript elongation in metazoans and its relevance to diseaseNature Reviews Molecular Cell Biology, Published online: 30 July 2026; doi:10.1038/s41580-026-01003-wThis Review discusses how transcript elongation by RNA polymerase II is regulated and how obstacles such as nucleosomes are overcome. Also discussed are the roles of transcription surveillance machineries, which ensure mRNA integrity and suppress spurious transcription, and how elongation defects contribute to diseases.dlvr.it

ICYMI: New Online! Modulating the degree of X-inactivation escape to establish causal links to sex-biased disease

Modulating the degree of X-inactivation escape to establish causal links to sex-biased diseaseNature Reviews Molecular Cell Biology, Published online: 29 July 2026; doi:10.1038/s41580-026-01007-6Gene escape from X-chromosome inactivation can cause sex-biased diseases. A workflow is presented to help find escape genes and experimentally manipulate their expression.dlvr.it

New Online! Exchange dynamics and kinetic control of gene regulation complexes

Exchange dynamics and kinetic control of gene regulation complexesNature Reviews Molecular Cell Biology, Published online: 30 July 2026; doi:10.1038/s41580-026-00991-zRecent evidence reveals how gene expression complexes form transient assemblies that continually exchange their subunits under kinetic control. This Perspective proposes that these dynamics form the basis of RNA processing and gene regulation.dlvr.it

New Online! At high noon, plants apply a condensate sunscreen

At high noon, plants apply a condensate sunscreenNature Reviews Molecular Cell Biology, Published online: 30 July 2026; doi:10.1038/s41580-026-01008-5MBS1 condensates induced by high light conditions shield chloroplasts and prevent accumulation of singlet oxygen, thereby conferring tolerance without reduction in photosynthesis.dlvr.it

New Online! Regulation of RNA transcript elongation in metazoans and its relevance to disease

Regulation of RNA transcript elongation in metazoans and its relevance to diseaseNature Reviews Molecular Cell Biology, Published online: 30 July 2026; doi:10.1038/s41580-026-01003-wThis Review discusses how transcript elongation by RNA polymerase II is regulated and how obstacles such as nucleosomes are overcome. Also discussed are the roles of transcription surveillance machineries, which ensure mRNA integrity and suppress spurious transcription, and how elongation defects contribute to diseases.dlvr.it

New Online! Modulating the degree of X-inactivation escape to establish causal links to sex-biased disease

Modulating the degree of X-inactivation escape to establish causal links to sex-biased diseaseNature Reviews Molecular Cell Biology, Published online: 29 July 2026; doi:10.1038/s41580-026-01007-6Gene escape from X-chromosome inactivation can cause sex-biased diseases. A workflow is presented to help find escape genes and experimentally manipulate their expression.dlvr.it

ICYMI: New Online! Mitochondrial tRNA biogenesis, modifications and disease relevance

Mitochondrial tRNA biogenesis, modifications and disease relevanceNature Reviews Molecular Cell Biology, Published online: 24 July 2026; doi:10.1038/s41580-026-00999-5Mitochondrial tRNA (mt-tRNA) biogenesis has evolved to support a degenerate mt-tRNA structure and a simplified genetic code. Liu and colleagues provide a fascinating overview of mt-tRNA biology, discuss how mt-tRNA-associated perturbations directly cause disease, and examine how emerging knowledge will lead to targeted therapeutics.dlvr.it

ICYMI: New Online! Mechanisms, regulation and clinical relevance of necroptosis

Mechanisms, regulation and clinical relevance of necroptosisNature Reviews Molecular Cell Biology, Published online: 21 July 2026; doi:10.1038/s41580-026-01002-xNecroptosis, a programmed cell death characterized by the formation of membrane pores and cell lysis, can be triggered by both cell-extrinsic and cell-intrinsic signals. This Review discusses mechanistic insights into necroptosis pathways mediated by receptors and by Z-nucleic acids.dlvr.it

New Online! Mitochondrial tRNA biogenesis, modifications and disease relevance

Mitochondrial tRNA biogenesis, modifications and disease relevanceNature Reviews Molecular Cell Biology, Published online: 24 July 2026; doi:10.1038/s41580-026-00999-5Mitochondrial tRNA (mt-tRNA) biogenesis has evolved to support a degenerate mt-tRNA structure and a simplified genetic code. Liu and colleagues provide a fascinating overview of mt-tRNA biology, discuss how mt-tRNA-associated perturbations directly cause disease, and examine how emerging knowledge will lead to targeted therapeutics.dlvr.it

ICYMI: New Online! Cellular and signalling mechanisms that regulate the blood–brain barrier

Cellular and signalling mechanisms that regulate the blood–brain barrierNature Reviews Molecular Cell Biology, Published online: 20 July 2026; doi:10.1038/s41580-026-01000-zThis Review summarizes the latest advances in blood–brain barrier (BBB) research, highlighting how emerging findings on the modulation of BBB function and heterogeneity by cellular interactions and signalling pathways might shape BBB-targeted therapeutics.dlvr.it

New Online! Mechanisms, regulation and clinical relevance of necroptosis

Mechanisms, regulation and clinical relevance of necroptosisNature Reviews Molecular Cell Biology, Published online: 21 July 2026; doi:10.1038/s41580-026-01002-xNecroptosis, a programmed cell death characterized by the formation of membrane pores and cell lysis, can be triggered by both cell-extrinsic and cell-intrinsic signals. This Review discusses mechanistic insights into necroptosis pathways mediated by receptors and by Z-nucleic acids.dlvr.it

New Online! Cellular and signalling mechanisms that regulate the blood–brain barrier

Cellular and signalling mechanisms that regulate the blood–brain barrierNature Reviews Molecular Cell Biology, Published online: 20 July 2026; doi:10.1038/s41580-026-01000-zThis Review summarizes the latest advances in blood–brain barrier (BBB) research, highlighting how emerging findings on the modulation of BBB function and heterogeneity by cellular interactions and signalling pathways might shape BBB-targeted therapeutics.dlvr.it

ICYMI: New Online! Factories, clusters, hubs, condensates — many names, one principle

Factories, clusters, hubs, condensates — many names, one principleNature Reviews Molecular Cell Biology, Published online: 15 July 2026; doi:10.1038/s41580-026-01001-yAlready thirty years ago, DNA replication, transcription and repair machineries were proposed to form and function in nuclear ‘factories’, later also dubbed hubs and condensates.dlvr.it

ICYMI: New Online! A demonstration that multivalent interactions drive condensate formation

A demonstration that multivalent interactions drive condensate formationNature Reviews Molecular Cell Biology, Published online: 13 July 2026; doi:10.1038/s41580-026-01004-9A demonstration that phase separation of biomolecules is promoted by multivalent interactions, which form dynamic polymer networks with cellular functions.dlvr.it

New Online! Factories, clusters, hubs, condensates — many names, one principle

Factories, clusters, hubs, condensates — many names, one principleNature Reviews Molecular Cell Biology, Published online: 15 July 2026; doi:10.1038/s41580-026-01001-yAlready thirty years ago, DNA replication, transcription and repair machineries were proposed to form and function in nuclear ‘factories’, later also dubbed hubs and condensates.dlvr.it

New Online! A demonstration that multivalent interactions drive condensate formation

A demonstration that multivalent interactions drive condensate formationNature Reviews Molecular Cell Biology, Published online: 13 July 2026; doi:10.1038/s41580-026-01004-9A demonstration that phase separation of biomolecules is promoted by multivalent interactions, which form dynamic polymer networks with cellular functions.dlvr.it