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Many thanks for this cool collaboration. It is so nice to see the complete story. Love that in vivo work can reveal mechanistic insights, like the MCM2-7 exit gate during helicase activation or the first base pairs that are unwound at replication origins. Well done!

Thanks Christoph! Have a lovely Christmas and a happy New Year.

Many thanks!

Hi Pedro. Thanks a lot for your reply. We have done an AlphaFold protein interaction screen and wonder if the data are true. Any advice would be greatly appreciated

Agreed