🧬 Delighted to share our new Nature Communications paper! We show how MCM2-7 double hexamers become active helicases and trigger DNA melting in vivo. Led by Chris Weekes & L. Maximilian Reuter. Congratulations to the whole team! doi.org/10.1038/s414... #DNAReplication
Mechanisms of MCM2–7 helicase activation and initial DNA melting at near base-pair resolution - Nature CommunicationsDNA replication begins when inactive helicases are switched on to unwind DNA. Here, the authors map this activation in yeast, revealing where DNA first melts and how helicase splitting, factor release...doi.org
