Профиль

Pablo Cárdenas R.

Профиль Vively

🦠 🧬 🇨🇴 • pathogens + evo + synbio + modeling • prof and lab leader at @mseelab.org • banner pic by Melanconnie

1,2 тыс. подписчиков472 подписок165 публикаций
⟳ Репост от Pablo Cárdenas R.
C. Brandon Ogbunu

A study I regularly circle back 2 from Dr. Pablo Cardenas-Ramirez, PI of @mseelab.org. Just now making use of the amazing computational tool (Opqua) that it introduces. With it, 1 can model fitness landscape scale ?s (e.g. valley crossing) @ the host-parasite scale www.science.org/doi/10.1126/...

Genomic epidemiological models describe pathogen evolution across fitness valleysA software tool creates flexible epidemiological simulations of evolving pathogens and shows how competition limits evolution.www.science.org
Pablo Cárdenas R.

Tetsu is an incredible scientist, mentor, and all-around person—can't recommend this lab enough. So stoked to be neighbors and get projects rolling!

Tetsuhiro Harimoto

I’ll be starting a lab as an Assistant Professor at Cornell @cornellengineering.bsky.social in 2026! We’ll combine synthetic biology and materials science to engineer microbes into living materials & therapies. We're recruiting PhD students & postdocs - please get in touch! 🔗 harimotolab.com

⟳ Репост от Pablo Cárdenas R.
Richard Neher

Building on the UShER tree of millions of SARS-CoV-2 genomes maintained by Angie Hinrichs, Hugh Haddox and Georg Angehrn (and others in @matsen.bsky.social lab and @jbloomlab.bsky.social) have looked into how the neutral mutation rate varies along the genome: [1/N] www.biorxiv.org/content/10.1...

The mutation rate of SARS-CoV-2 is highly variable between sites and is influenced by sequence context, genomic region, and RNA structureRNA viruses like SARS-CoV-2 have a high mutation rate, which contributes to their rapid evolution. The rate of mutations depends on the mutation type (e.g., A→C, A→G, etc.) and can vary between sites ...www.biorxiv.org
⟳ Репост от Pablo Cárdenas R.
Tom Peacock

Really proud to share our preprint describing early adaptation of H5N1 to US dairy cattle, and showing how these mutations enhance the ability of the virus to infect other mammals, such as pigs and humans. With @influenzal.bsky.social @vidhid.bsky.social @drclairesmith.bsky.social and many more!

Polymerase mutations underlie adaptation of H5N1 influenza virus to dairy cattle and other mammals.In early 2024, an unprecedented outbreak of H5N1 high pathogenicity avian influenza was detected in dairy cattle in the USA. The epidemic remains uncontrolled, with spillbacks into poultry, wild birds...www.biorxiv.org
⟳ Репост от Pablo Cárdenas R.
Solid Evidence

I’m pleased to share that we FINALLY submitted our latest manuscript on SARS-CoV-2 cryptic lineages and what they tell us about the origins of COVID-19. This was a ton of work. medrxiv.org/cgi/content/... 1/

Detecting SARS-CoV-2 Cryptic Lineages using Publicly Available Whole Genome Wastewater Sequencing DataBeginning in early 2021, unique and highly divergent lineages of SARS-CoV-2 were sporadically found in wastewater sewersheds using a sequencing strategy focused on the most mutagenic region of SARS-Co...medrxiv.org
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