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In new study led by @bdadonaite.bsky.social, we show many influenza HAs (H5, H7, H9, H1, H2, H3) can use avian or human MHC-II to enter cells. We then use novel combo of deep mutational scanning & cryoEM to define how H5 HA binds to avian MHC-II. Preprint: doi.org/10.64898/202...

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Here are the slides I am presenting at this morning's @ceirrnetwork.bsky.social seminar related to characterizing the human neutralizing antibody landscape to human seasonal influenza for purposes such as vaccine strain selection: slides.com/jbloom/flu-s...

flu-seqneut-2025to2026Near real-time data on the human neutralizing antibody landscape to influenza virus to inform vaccine-strain selection in September 2025slides.com

In new study led by Brendan Larsen, we map functional constraint across the Nipah virus F protein to define constrained epitopes for antibody targeting and identify mutations that stabilize the prefusion conformation for vaccine immunogens. www.pnas.org/doi/10.1073/...

Functional and antigenic constraints on the Nipah virus fusion protein | PNASNipah virus is a highly pathogenic virus in the family Paramyxoviridae that utilizes two distinct surface glycoproteins to infect cells. The recept...www.pnas.org

In new study we examine constraints on evolution of endemic "common-cold" coronavirus 229E We find strong tradeoff between antibody neutralization & receptor binding, due to up-down position of spike RBD www.biorxiv.org/content/10.6... See lead author Sheri Harari's summary: x.com/SheriHarari/...

We have posted data providing real-time measurement of human neutralizing antibody landscape to seasonal influenza. Data explain spread of subclades K (H3N2) & D.3.1.1 (H1N1), identify subclade K subvariants w reduced neutralization, & can inform choice of strains for next vaccine.

In new study led by @ckikawa.bsky.social, we provide near real-time data on human neutralizing antibody landscape to influenza by measuring ~26,000 titers to >100 recent viral strains Data can inform vaccine selection & evolutionary/epidemiological modeling www.biorxiv.org/content/10.1...

Near real-time data on the human neutralizing antibody landscape to influenza virus to inform vaccine-strain selection in September 2025The hemagglutinin of human influenza virus evolves rapidly to erode neutralizing antibody immunity. Twice per year, new vaccine strains are selected with the goal of providing maximum protection again...www.biorxiv.org