Virus origins/diversity/evolution; mobilome; Archaea. Head of the Cell Biology and Virology of Archaea Unit at Institut Pasteur: https://research.pasteur.fr/en/team/archaeal-virology/
We’re so excited to share our new paper, where we tackle the wealth of structural and functional diversity of anti-phage sensors across bacteria (1/6)
NatureNature research paper: Diverse bacterial pattern recognition receptors sense the core phage proteome go.nature.com/45fpXCZ
🎉final print version in PLOS Genetics @sullivan-lab.bsky.social @biosci.lbl.gov journals.plos.org/plosgenetics...
Cross-family and phage-specific gene requirements for Klebsiella infection revealed by scalable RB-TnSeq genetic screensAuthor summary Bacteriophages, or phages, are viruses that infect bacteria and play central roles in shaping microbial communities across ecosystems. Despite their ecological importance, the bacterial...journals.plos.orgVivek MutalikNew paper 🔔 Collaboration @sullivan-lab.bsky.social Marissa Gittrich led the work Klebsiella phage biology has focused almost entirely on capsulated strains, but capsule loss is the #1 resistance mechanism under phage predation. We used a naturally acapsular host to reveal the receptor landscape
Bacteriocins in archaea and archaeocins in bacteria. @romainstrock.bsky.social surveys the the exchange of molecular weaponry between archaea and bacteria. www.biorxiv.org/content/10.6...
Bacteriocins in archaea and archaeocins in bacteriaArchaea and bacteria routinely live side by side in microbial communities and must interact at least on occasion. Whether such cross-Domain interactions are dominated by mutual disregard, co-operation...www.biorxiv.org
Phage hijacks host phosphorothioate DNA modification machinery to circumvent bacterial Ssp defences | Nature Microbiology
Phage hijacks host phosphorothioate DNA modification machinery to circumvent bacterial Ssp defences - Nature MicrobiologyThe phage-encoded protein PptA enables its DNA to masquerade as the host and evade cleavage, providing a potential foundation for engineering therapeutic phages that could bypass this widespread defence system.www.nature.com
Discovery of a Turing reaction-diffusion system in Archaea! www.biorxiv.org/content/10.6...
A self-organized geometry sensing oscillator spatially regulates cell division in archaeaCell division must be tightly regulate in time and space. Many bacteria and eukaryotes employ geometry sensing systems to regulate cell division spatiotemporally. However, how archaea ensure they divi...www.biorxiv.org
Clever little buggers, geminiviruses...😎
GeminiTeamLabHow does a geminivirus replicate its genome using a pick&mix strategy with host proteins? 🦠🦠🌱🧬 Our new preprint identifies plant proteins repurposed by geminiviruses to carry out rolling-circle replication. Congrats @chaonan123.bsky.social , who spearheaded this work! www.biorxiv.org/content/10.6...
Surface architecture of the bacterial envelope determines phage adsorption route in pathogenic Escherichia coli O157:H7 www.biorxiv.org/content/10.6...
Surface architecture of the bacterial envelope determines phage adsorption route in pathogenic Escherichia coli O157:H7The outermost surface layers of Gram-negative bacteria determine phage access to terminal receptors, yet their genetic basis has been mapped almost exclusively in laboratory strains that lack them. He...www.biorxiv.org
Come work on exciting AI for biology projects in Paris!! 🇫🇷 Details and application below, deadline sept 1st!
Antigen Evolution & Design Lab🚨 JOB ALERT🚨 We are very excited to be hiring the lab's ✨very first postdoc✨! Work on new AI technologies for decoding antigen protein evolution in a fresh research environment, at the heart of Paris 🇫🇷 Details & link to apply: research.pasteur.fr/en/job/postd... Deadline: Sep 1st
Check out this fun collaboration on phages and Polyamines with the Marshall Lab! #microsky #phagesky 🧪🧫🧬🔬
Chris MarshallThis is our 2nd recently posted paper where we wanted to build off the fantastic 2023 PNAS paper by @prsecor.bsky.social group (www.pnas.org/doi/10.1073/...) 1/3
Characterizing the ecological niche of insertion sequences within prokaryotic genomes academic.oup.com/ismej/advanc... #jcampubs
Characterizing the ecological niche of insertion sequences within prokaryotic genomesAbstract. Insertion sequences (ISs) are widespread prokaryotic transposable elements, often regarded as genomic parasites that primarily cause deleteriousacademic.oup.com
Our paper out in Science today: The Metis defense system senses molecular byproducts released when a phage degrades the bacterial genome, and then prevents replication of the phage in the infected cell Congratulations @ostermanilya.bsky.social and co-authors!
Bacteria sense virus-induced genome degradation via methylated mononucleotidesPhages often degrade the genome of their bacterial host to individual nucleotides. Here we describe Metis, a bacterial defense system that directly senses phage-mediated host genome degradation. Metis...www.science.orgOsterman IlyaExcited to share that our Metis story is now published in Science! 🎉 Bacteria can sense phage-induced degradation of their genome and activate immunity. Many thanks to everyone who contributed to this work. 📄 www.science.org/doi/10.1126/... More details in my earlier thread 🧵⬇️
#microsky New preprint from the lab! Widespread immune systems protect bacteria against conjugative plasmids www.biorxiv.org/content/10.6... Kudos to the extremely talented lead author Ludovic Poiré! Key contributions by @francoisrousset.bsky.social and also help from C. Lesterlin/TacC lab. 🧵⬇️
Widespread immune systems protect bacteria against conjugative plasmidsConjugative plasmids are a class of mobile genetic elements capable of efficient transfer between bacterial cells. Although they can introduce beneficial traits such as antibiotic resistance to recipi...www.biorxiv.orgLab account is official! go follow @antigenevo.bsky.social 👇👇👇 research.pasteur.fr/en/team/anti...
Antigen Evolution & Design - ResearchMost pathogens have proteins on their surface which are recognised by our immune system and prime it to make antibodies that protect us from future infection. Vaccines contain these proteins to activa...research.pasteur.frAntigen Evolution & Design LabInaugural post! We are a brand new lab @pasteur.fr studying how pathogen antigens evolve and how we can exploit these proteins' evolution to make better vaccines! Read a few words from the currently sole member of the lab @spyroslytras.bsky.social below! 😁 www.pasteur.fr/en/research-...
🚨 Registration for VEGA26 is 👏 officially open 👏 🚨 The 5th edition of our Viral EcoGenomics and Applications symposium will be held November 18-19, 2026, on the UC Berkeley campus 🧬 🦠 🔬 🧫 Event website ➡️ jgi.doe.gov/work-with-us... Registration link ➡️ cvent.me/e0RnA0
Excited to share our new preprint led by Fred and me in collaboration with the archaeal community! We found that the molecular foundation of histone-based chromatin has pre-eukaryotic roots in Asgard archaea. (1/4) #ArchaeaSky www.biorxiv.org/content/10.6...
Emergence of histone-based chromatin complexity in Asgard archaeaThe emergence of the eukaryotes coincided with the diversification of histone proteins and their post-translational modifications by enzymes that constitute the core of eukaryotic chromatin. Yet the e...www.biorxiv.org🚨New paper alert 🚨 Here we tried to leverage an (incredible) metagenome time-series to better understand MGE diversity and activity in soil across decade(s). @scbagby.bsky.social has an amazing thread about this work with all the details - bsky.app/profile/scba...
Mobile genetic elements shape microbial diversity and functions in thawing permafrost soils - Nature MicrobiologyAn 8-year soil meta-omic time series shows how mobile genetic elements shape permafrost microbial diversity and impact a range of functions, including carbon and nutrient cycling.www.nature.comSarah BagbyOut today in Nature Microbiology: a paper that started in 2021 with an email from @sullivan-lab.bsky.social. Subject line: "Crazy ideas". www.nature.com/articles/s41... 1/23
Microbes that have the greatest genomic potential for secondary metabolism tend to be multicellular. Here, we show that signatures of ancestral BGC expansions within 3 bacterial phyla and 2 fungal lineages coincide with origins of complex multicellularity [1/12] 🧵 www.nature.com/articles/s41...
Complex multicellularity is linked with expanded specialized metabolite production in microorganisms - Nature MicrobiologyThe evolutionary emergence of complex multicellularity in bacteria and fungi, such as the ability for mycelial growth, is strongly associated with increased genomic carriage of biosynthetic machinery ...www.nature.com
#gbdraw v0.12.1 is now live with a massive update! Powerful new features are now available in your local environment: You can now generate circular comparisons (homology rings) and interactive SVG files directly on your machine 🧬 #bioinformatics #genomics
Review summarises how viruses dominate genetic diversity on Earth and evolve through multiple origins, gene sharing, and host–virus arms races, reshaping the global virosphere and replicator space 🧬🌍🦠 #Virology #Evolution #Metagenomics 📄 doi.org/10.5802/crbi... 👤 EVBC member: Mart Krupovic
Organization and evolution of the virosphere and the replicator space doi.org
Our paper on the evolution of cellular miniaturization is now out in PNAS! www.pnas.org/doi/10.1073/... A short recap 🧵
PNASProceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...www.pnas.orgMarco Fumasoni🗞️ New preprint from the lab, led by our postdoc Ana Garoña (not on here) in collab with @andreagiometto.bsky.social: “Experimental evolution of cellular miniaturization reveals a mechanism for cell size evolution”, aka: “honey, we shrank the yeasts!” 🎥 www.biorxiv.org/content/10.6...