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1/ I'm excited to share that we're launching NECB 2026, the inaugural New England Computational Biology Symposium. Oct 1-2 at Microsoft Research New England, Cambridge. Two days of keynotes,talks, and posters to bring our community together across institutions.Space is limited. newenglandcompbio.org

Tiberius predicts genes in eukaryotic genomes via our web service bioinf.uni-greifswald.de/tiberius/ #genomeannotation #geneprediction #eukaryotes

HPRC2: A human pangenome reference with near-complete coverage of common genetic variation https://www.biorxiv.org/content/10.64898/2026.07.21.739710v1

BTW: while we were trying to optimise IO from bam/cram in our rust-based methylation/variant calling tool "rastair", we ended up re-implementing htslib with a focus on better pileup performance: docs.rs/seqair/lates... It seems to make a big speed difference for us, would love to get feedback

Just added a couple more job apps (thanks Rachel and Arun!) but if you've gotten a job in industry, academia (R1, PUI, whatever!) in the last 5 years or so, please consider submitting your job app materials to help other folks! github.com/RILAB/statem...

GitHub - RILAB/statements: Successful Job Applications and GrantsSuccessful Job Applications and Grants. Contribute to RILAB/statements development by creating an account on GitHub.github.com

How good is MiniBWA, the successor to BWA? To test it, I ran MiniBWA on sequencing from 76 different species, comparing mapping speed, rate and accuracy with BWA MEM. In short, it's really good. If you map short reads, it's well worth your time. andrewcarroll.github.io/2026/06/30/t...

New on the Fulcrum blog: minibwa, a faster mapper from @lh3lh3.bsky.social and our @nilshomer.com Its speed is great, yes, but more interesting is the decision to revisit BWA-MEM as infrastructure – keep what still works, change what limits performance, then test downstream impact. shorturl.at/xxqeI

Minibwa: alignment is never solvedHeng Li and Nils Homer revisit BWA-MEM with a faster mapper for short reads, accurate long reads, and bisulfite sequencing data.blog.fulcrumgenomics.com

Congratulations to Prof Richard Durbin, winner of the 2026 Genetics Society Medal! His pioneering work in computational genomics has transformed how we analyse and understand genome sequences.

Introducing nail - a Rust implementation of profile HMM sequence alignment for proteins. Near-HMMER sensitivity, but a lot faster: www.biorxiv.org/content/10.1... github.com/TravisWheele...

Our method, savont, for generating amplicon sequence variants (ASVs) for long-read amplicons is now on bioRxiv. Work with @lh3lh3.bsky.social and help from @mkddueholm.bsky.social and team (Marie Riisgaard-Jensen, @kirk3gaard.bsky.social, Kasper Skytte Andersen) github.com/bluenote-157... 1/6

Sensitive long-read amplicon sequence variant recovery with savont https://www.biorxiv.org/content/10.64898/2026.05.26.727271v1

Excited to speak at ASM Microbe 2026 in the Oxford Nanopore session about new tools for long-read metagenomics + 16S sequencing. If you're attending ASM Microbe June 4-7 in D.C. and want to chat, let me know!

Summary of Key Changes in OMB’s Proposed Federal Financial Assistance Rule. Russell Vought is going destroy American Science. elizabethginexi.substack.com/p/summary-of...

Summary of Key Changes in OMB’s Proposed Federal Financial Assistance RuleRussell Vought is going destroy American Scienceelizabethginexi.substack.com

Please share widely! We will imminently be posting a technician position in our lab group since @rheasood.bsky.social is off to grad school 🙌! If you know of anyone excited about molecular biology, evolution, and functional genomics please have them reach out (schumer at stanford). Start date ~June

Ver excited to share my just-published Darwin Review with @lh3lh3.bsky.social on population-scale long-read sequencing! royalsocietypublishing.org/rspb/article...

Population-scale long-read DNA sequencing: peering under the hood of the new evolutionary genomicsAbstract. Population-scale long-read DNA sequencing (PLRS) is rapidly reshaping our understanding of genomic variation in humans and non-model species. Inroyalsocietypublishing.org

If you use fgbio or UMIs at all, you should start using fgumi. Up to 100x faster, and soon 2x faster sort than samtools, it’s been a labor of love and something we’ve wanted to do for a long time.

If you use our fgbio UMI tooling today, you owe it to yourself to check out fgumi! Massively faster re-write into Rust by @nilshomer.com with 100% reproduction of the fgbio outputs!

Myloasm, our long-read metagenome assembler, is now published! w/ @mgmarin.bsky.social and @lh3lh3.bsky.social Very rewarding after > a year of development and countless hours thinking about assembly. Thanks to beta testers, Li lab, and reviewers who gave very helpful feedback. rdcu.be/famFj

High-resolution metagenome assembly for modern long reads with myloasmNature Biotechnology - A long-read metagenome assembly method recovers circular and complete genomes better than existing tools.rdcu.be

High-resolution metagenome assembly for modern long reads with myloasm - @lh3lh3.bsky.social @jimshaw.bsky.social @danafarber.bsky.social @harvardmed.bsky.social go.nature.com/3PBEwvR

High-resolution metagenome assembly for modern long reads with myloasm - Nature BiotechnologyA long-read metagenome assembly method recovers circular and complete genomes better than existing tools.go.nature.com

_720 Gbp_ marine nanopore metagenome -> 328 circular prokaryotic contigs: using myloasm! Insane work by Lui and Nielsen. Also shows how modern long read assemblies can disentangle coexisting strains and reveal ecological insights.