RNA biology lab studying cell fate and cell identity in the context of embryonic development and disease @Goethe University #ribosome #translational_control #RBP #splicing #RNA_localizatilzon https://kurianlab.com/ Alum:@salkinstitute @yeo lab, UCSD
www.nature.com/articles/s41... how cool!
Intestinal stem cells count self-renewal divisions to switch multipotency - NatureIn Drosophila, cell fate switching in adult intestinal stem cells is determined through an epigenetic mechanism in which these cells count divisions, switching from producing enterocytes to producing ...www.nature.comwww.science.org/doi/10.1126/... Check this beauty from @benoitbruneau.bsky.social and colleagues
Dose-dependent sensitivity of human three-dimensional chromatin to a heart disease–linked transcription factorDosage-sensitive transcription factors (TFs) underlie altered gene regulation in human developmental disorders, and cell type–specific gene regulation is linked to the reorganization of three-dimensio...www.science.orgBeautiful work at the intersection of 3d genome biology, splicing and senescence from @akispapantonis.bsky.social Congrats buddy.
Akis (Argyris) PapantonisOur latest is now out in @nataging.nature.com giving reason to celebrate! Led by talented Spiros Palikyras, it improves our preprint (posted 2 years ago!) dissecting the mechanism and functional consequences of CTCF clustering upon senescence commitment of human cells. www.nature.com/articles/s43...
2 super cool papers on pre-mRNA splicing: www.cell.com/cell/abstrac... www.biorxiv.org/content/10.6...
Spliceosome loss in the red tide ciliate Mesodinium rubrum presents a symbiotic cul-de-sacMesodinium rubrum , a marine microbial eukaryote associated with some of the largest red tides on Earth, has the remarkable ability to commandeer the plastids, mitochondria and nuclei from the alga Te...www.biorxiv.orgHow cool!!
Nicholas BellonoHow did octopuses evolve novel traits? Rishav Mitra, Richard Han, Trey Scott, et al serendipitously discover a unique ribosome adaptation that increases the accuracy of protein synthesis and evolved alongside their elaborate nervous systems vs deep sea relatives. www.biorxiv.org/content/10.6...
www.nature.com/articles/s41...
Chemically synthesized, non-capped and non-polyadenylated peptide-coding RNA efficiently induces antigen-specific CD8+ T cells - Nature Biomedical EngineeringChemRNAs are chemically synthesized RNA lacking typical mRNA features that are nevertheless efficiently translated by CD8+ T cells to overcome limitations associated with in vitro transcription for de...www.nature.comwww.nature.com/articles/s41... 🤯
A secreted endosymbiont protein essential for colonizing host cells - NatureSyeA was present in the Buchnera ancestor, is secreted into the host cytoplasm, is homologous to secreted effectors of bacterial pathogens and is essential for Buchnera transmission.www.nature.comCheck this
Kazuhiro MaeshimaOur new preprint @biorxivpreprint.bsky.social, led by @katsuminami.bsky.social et al.! 🎉 www.biorxiv.org/content/10.6... Machine learning-assisted Repli-Histo labeling and single-nucleosome imaging reveal distinct transcription-dependent chromatin constraints across euchromatin and heterochromatin.
Key findings in RNA subcellular localization motif 'language' 👏👏👏👏👏
Matthew TaliaferroNew paper! How do RNAs "know" where to go inside a cell? We dug into the sequence elements that route RNAs to the right place. It turns out that, in mammals, they're surprisingly massive (>200 nt), multipartite, and wonderfully complicated. 🧵
www.science.org/doi/10.1126/... Really clever
Patterning human kidney organoids with synthetic Wnt-secreting organizersHuman stem cell–derived miniature organs, including kidney organoids, reproduce aspects of tissue development but lack reliable spatial patterning. In embryos, spatial organization is often establishe...www.science.orgRibo-Tweezer by @mbarnalab.bsky.social, a modular platform to deplete proteins from mature ribosomes . www.cell.com/molecular-ce... @jakub-zeman.bsky.social and I wrote a Preview on why this helps to turn ribosome heterogeneity into an experimentally testable paradigm www.cell.com/molecular-ce...
Tweezing apart ribosome heterogeneityIn this issue of Molecular Cell, Chen et al. introduce Ribo-Tweezer: a modular platform
for conditionally and selectively depleting proteins from mature ribosomes, enabling
direct tests of their ribos...www.cell.com*highly recommended* Mathias is brilliant and an super nice person to work with
Mathias MunschauerOne of the best parts of leading a department is the opportunity to recruit exceptional people who will shape its future. Today, I'm thrilled to share that we are recruiting a W3 Professor of Translational Hepatitis Virus Research at Heidelberg University. www.nature.com/naturecareer...
From Kidmaxing to use of 'latest tech advances,' we are in good hands: www.nytimes.com/2026/07/01/o...
Opinion | Is Kidmaxxing the Ultimate Status Symbol for Ultimate Wealth?www.nytimes.comNature PortfolioUsing burgers as a model system, a generative #AI system rediscovers the classic Big Mac without explicit supervision and generates novel burgers optimized for deliciousness, sustainability, or nutrition, according to a paper in npj Science of Food. go.nature.com/4v1GR23 🧪
