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Similar think happened at JOCI. The community has founded JHI in response, and looks like we gained a spectarcular society journal as a result of springers greed. retractionwatch.com/2025/02/06/e...

Editors resign from Springer immunology journal to launch nonprofit titleSeveral top editors of the Journal of Clinical Immunology, a Springer Nature title, have jumped ship to start a new, nonprofit journal with Rockefeller University Press.  Jean-Laurent Casanova…retractionwatch.com

There seems to be a problem with incentives for replication here. If the replicators cant replicate the data, the paper wont get published and neither will their work on replicating it. They shoot themselves in the leg. And that is ignoring the problem that NOONE will agree to try to replicate.

They're just really trying to milk the whole publishing landscape dry... Scientists need to stop feeding this machine. The OA initiative is nice, but not if 80-90% of the public money goes into companies with >50% profit margins... All this could go through university presses and societies.

Very nice! Congrats to all involved!

😅

What did the central dogma do to you? 🫠

Super cool! thank you

Ruthless...

JHI @jhumimmunity.org is the journal of the primary immunodeficiency societies worldwide, hosted by Rockefeller University Press. Open access: doi.org/10.70962/jhi... With Qinhua Zhou, Jacinta Bustamante, Jean-Laurent @casanovalab.bsky.social , and colleagues from six countries.

Complete and partial forms of X-linked MCTS1 deficiency in patients with mycobacterial diseaseX-linked MCTS1 deficiency causes susceptibility to mycobacterial disease. Four new patients carried three previously undescribed truncating or loss-of-exprdoi.org

Building on our 2023 paper, we identified three new MCTS1 variants, including the first hypomorphic variant (p.W175*). Even partial loss of MCTS1 translation reinitiation activity can cause susceptibility to mycobacteria.

Not yet, but I would love to!!

Support dogs guide blind people all day long but never become blind? What can we learn?

Awesome, thanks for the enthusiasm!!

Finally, I do think it is really worth understanding what you're doing when analyzing such data, otherwise what you get out might not be very useful! So a bioinfo course could be a great idea! Good luck!

Is this question just abou data analysis or also about producing a new dataset in an experiment? Most published datasets have already count matrices submitted to repositories such as NCBI Geo or similar, maybe you wont need to do the analysis. Otherwise usegalaxy.org is the easiest solution I know.

Thank you Kilian!!

Thank you!!!

Huge thanks also to all the amazing collaborators and colleagues all around the world, who made this happen. Finally, many, many thanks to the patients and their families for supporting and enabling our research. fin/n

Huge thanks and congrats go to exceptional first authors Taja Vatovec (in my lab) and my friend Anna-Lena Neehus @alneehus.bsky.social in Boston! Furthermore, many thanks to @casanovalab.bsky.social for letting me start this project in Paris. 5/n

We also found striking defects in B cell function in vivo, by studying the response to SARS.CoV2 mRNA vaccination in a subset of patients. For many more interesting obsevations and experiments, please read the paper! 4/n