Group leader at the Gene Center in Munich. RNA biology and protein translation in Immunity. Looking for excited and motivated students! Dad in Science, He/His Bohlenlab.com
Very interesting paper on defect in RNA editing: rupress.org/jem/article-...
ADAR1 loss-of-function variants altering RNA editing define a new interferon-dependent psoriasis subtypeIn this work, we identify a new type I IFN–dependent psoriasis subtype resulting from rare heterozygous variants in ADAR1 and associated with a specific rerupress.orgHappy to see this story out! Congrats to Diana and everyone involved :)
Rockefeller University PressIn @jem.org, Olguín Calderón et al. report four rare or common hypomorphic IL23R variants that, when present in the homozygous state, impair IFN-γ production by innate-like T and NK cells, thereby conferring a predisposition to #tuberculosis. rupress.org/jem/article/... @casanovalab.bsky.social
Wow! That's very bad! Great investigative work. @reeserichardson.bsky.social reeserichardson.blog/2026/05/28/h...
How much of Thermo Fisher’s antibody data has been manipulated?We’ve documented more than 100 instances of apparent data manipulation in Thermo’s catalogreeserichardson.blogWow, cool! Adult onset autoimmunity can be genetic.
Journal of Human ImmunitySTING gain-of-function has primarily been described to cause pediatric-onset disease. Here, Riley, Kotzin, Finck, Miner et al. report a surprisingly high prevalence of adult-onset #SAVI among patients with common #autoimmune disease diagnoses. rupress.org/jhi/article/... #Autoimmunity #IEIs
Amazing work, contextualizing the mechanism of action of the widely used chemotherapeutic azacytidine. We are very happy to have contributed a little bit to this manuscript! Big congrats to Julian, Carla and everyone involved!
Gene Center Munich @LMU Munich📣Publication alert: Julian Stingele and his team show that the chemotherapeutic drug azacitidine damages RNA and reveal a possible approach to improve therapies🤩👏 www.sciencedirect.com/science/arti... @jstingele.bsky.social @lmu.de @shubozhao.bsky.social
I am excited to receive this fellowship, which will help us with our research on regulated mRNA translation in the human immune system! www.daimler-benz-stiftung.de/cms/de/foerd...
Daimler und Benz Stiftung – Stipendiaten 2026Die Daimler und Benz Stiftung gibt Impulse – heute für Morgen. Über Ländergrenzen hinweg fördert sie interdisziplinäre Forschungsprojekte.www.daimler-benz-stiftung.deI am very excited to share that our paper is on the cover of this month's JHI! rupress.org/jhi/issue/2/2
New paper in the Journal of Human Immunity! We report complete and partial forms of X-linked MCTS1 deficiency in patients with mycobacterial disease -- four new families from Iran, Oman, China, and the USA. doi.org/10.70962/jhi...
Complete and partial forms of X-linked MCTS1 deficiency in patients with mycobacterial diseaseX-linked MCTS1 deficiency causes susceptibility to mycobacterial disease. Four new patients carried three previously undescribed truncating or loss-of-exprdoi.orgOur lab website is live! 🥳 We study how mRNA translation controls immune cell function and how defects in the protein synthesis machinery cause human disease. Come say hello and learn about what we do at the Gene Center Munich. bohlenlab.com
I don't want to be a huge stickler and I actually really like this paper, congrats to the authors for the nice work. But isn't the use of human eyes in the graphical abstract rather misleading for a paper that contains entirely mouse experiments?
γδ T cell ForumCommensal-derived trehalose monocorynomycolate triggers γδ T cell-driven protective ocular barrier immunity #gdTcells @cp-immunity.bsky.social
🥳 We are excited to share the first publication from the Bohlen Lab! "Somatic deficiency of the human E3 ubiquitin ligase CBL in leukocytes impairs B but not T cell development and function" www.nature.com/articles/s41... together with the Tangye Lab and @bloodgenes.bsky.social and many more! 1/n
Somatic deficiency of the human E3 ubiquitin ligase CBL in leukocytes impairs B cell but not T cell development and function - Nature ImmunologyBohlen and colleagues report that the E3 ubiquitin ligase CBL is necessary for the development, tolerance and activation of B cells in humans, unlike in mice where CBL deficiency results in loss of T ...www.nature.comHonored to get this opportunity to build out my team and explore molecular immunology!
Gene Center Munich @LMU Munich🥳🥂Huge congratulations to Jonathan Bohlen on being awarded an Emmy Noether Grant by @dfg.de 😊🤩 His project addresses a central open question in immunology: how mRNA translation governs the function of T cells. www.genzentrum.uni-muenchen.de/news-events/... @jonathanbohlen.bsky.social
We report a 5'UTR variant in YEATS4 that confers resistance to tuberculosis through altering the translation of the YEATS4 open-reading frame! Congrats to Clement Conil and colleagues at @casanovalab.bsky.social! It was fun to help with this story! link.springer.com/article/10.1...
A human YEATS4 variant confers resistance to TST and IGRA conversion despite Mycobacterium tuberculosis exposure - Genome MedicineBackground Despite sustained exposure to Mycobacterium tuberculosis (Mtb), some individuals—so-called resisters—have persistently negative results for the tuberculin skin test (TST) and interferon-gam...link.springer.com