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🔬 Recruiting a Physician Scientist PhD student (San Raffaele, Milan) via AIRC-Cariplo-SEMM-UniMi program. Project: reprogramming tumor endothelium to restore anti-tumor immunity in liver cancer. Keep 20% clinical work. Deadline Sept 16. Apply: tinyurl.com/3vcp27dp #AIRC

Great science and fun at our lab's annual retreat, bringing together my team with @mirelakuka.bsky.social, Marco De Giovanni, and Donato Inverso's teams. Thanks to @lozanzi.bsky.social and Stefano Sammicheli for inspiring lectures and great questions. Proud of what we've built together.

In vista della Giornata Mondiale dell'Epatite (28 luglio), abbiamo raccontato a UniSR le due strategie complementari su cui lavoriamo per la cura funzionale dell'epatite B cronica 🔗 blog.unisr.it/cura-funzion...

Cura funzionale epatite B cronica: le nuove strategieAntivirali di nuova generazione e immunoterapia: le strategie con cui UniSR e IRCCS San Raffaele affrontano la cura funzionale dell'epatite B cronica.blog.unisr.it

Huge congrats to Dr. Valentina Venzin, former PhD student in my lab, for being awarded the EFIS ACTERIA Doctoral Thesis Prize in Immunology! Her discovery of a liver-intrinsic CD4-to-CD8 T cell rescue circuit via IL-27 was a really elegant piece of work. So proud of her! www.efis.org/news/the-fon...

Pleased to have contributed to this new @science.org paper on how lymphoid tissue chemokines limit CD8⁺ T cell priming duration to preserve T cell functionality. Congrats to Lukas Altenburger and Jens Stein! t.co/K9Cmt8yO9C

Great fun to write this review on Kupffer cells with Florent Ginhoux and Paul Kubes, covering origin, diversity and roles in immunity and metabolism, now out in @natrevimmunol.nature.com. Huge credit to Bruna Araujo David, Francesco Andreata and Camille Blériot for driving this work. t.co/rGpmTMRddV

Neutralizing antibodies are not the whole story. In our Comment in Nature Reviews Immunology, we highlight an alternative mode of protection: 👉 T cells can eliminate infection at its earliest stage — before it becomes detectable We term this “abortive infection” 🔗 rdcu.be/fbq8p Thread 1/4

Abortive infection: T cells as early, antibody-independent defendersNature Reviews Immunology - Neutralizing antibodies are widely viewed as the frontline of antiviral defence. Yet emerging evidence reveals that T cells can terminate infection before it is...rdcu.be

Excited to organize @keystoneSymposia.bsky.social Tissue and Spatial Immunology with @leilaakkari.bsky.social and Hai Qi in February 2027! Join us to explore emerging research in Banff! keysym.us/KSSpatialImmune27 #KSSpatialImmune27

Tissue and Spatial Immunology | Keystone SymposiaJoin us at the Keystone Symposia on Tissue and Spatial Immunology, February 2027, in Banff, with field leaders!keysym.us

Join us for the 2026 GRC Immunochemistry and Immunobiology "Immune Circuitry and Molecular Pathways in Tissue Homeostasis, Infection, and Disease" in beautiful Barcelona. June 28 - July 3, 2026. Great lineup of speakers! www.grc.org/immunochemis...

Don't miss the 2026 Global Immunotalks!

Great story from the Nieswandt lab in Science: uncovering a non-classical platelet mechanism that drives inflammation via integrin- and tetraspanin-rich tethers. A fresh angle on thrombo-inflammation. Happy to be part of this work! www.science.org/doi/10.1126/...

Platelet-derived integrin- and tetraspanin-enriched tethers exacerbate severe inflammationPlatelet integrin αIIbβ3 is essential for hemostasis, thrombosis, and inflammation. We found that ligation of αIIbβ3 by von Willebrand factor or fibrin under flow triggered its accumulation in plasma ...www.science.org

1/ New from our lab 🧪 ARTC2 blockade is widely used to protect tissue Tregs — but when is it truly essential, and for which subsets? 2/ In this @eurjimmunol.bsky.social update, we dissect the subset-specific and context-dependent effects of ARTC2 blockade on hepatic Treg recovery.

Optimising Recovery of Hepatic Regulatory T Cells: A Practical Guide Using ARTC2 BlockadeThis is an update to the Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition), Chapter 3: 12C, by Cossarizza et al. Administration of anti-ARTC2 nanobody...onlinelibrary.wiley.com

Thrilled to contribute to this landmark consensus effort led by Dave Masopust and Rafi Ahmed. A major step toward clearer, shared T cell nomenclature for the field. www.nature.com/articles/s41...

Guidelines for T cell nomenclature - Nature Reviews ImmunologyThis Consensus Statement clarifies the existing subset-based nomenclature for T cells. Furthermore, it proposes an alternative modular nomenclature that is designed to be brief and flexible and to avo...www.nature.com

Honoured to see our @natimmunol.nature.com study highlighted in a thoughtful @jhepatology.bsky.social commentary on the IL-27/Kupffer cell axis in chronic HBV — a great summary of why tissue immunity matters and of our work. Paper: tinyurl.com/yt652mxa Commentary: tinyurl.com/56pke5x5

CD4+ T cells license Kupffer cells to reverse CD8+ T cell dysfunction induced by hepatocellular priming - Nature ImmunologyHere the authors show that CD4+ effector T cells prevent or reverse CD8+ T cell dysfunction by licensing Kupffer cells to trigger IL-27 production, defining a liver-specific immune circuit and a poten...www.nature.com

New review out in @cp-trendsimmuno.bsky.social! With @valentinavenzin.bsky.social, we revisit IL-27 as a central regulator of CD8⁺ T cell fate — integrating insights from infection, cancer, and autoimmunity, and outlining its therapeutic potential. www.sciencedirect.com/science/arti...

Reframing IL-27: a central regulator of CD8+ T cell immunityInterleukin-27 (IL-27), a member of the IL-12 cytokine family, was long viewed primarily as a regulator of CD4+ T cell immunity. Subsequent studies re…www.sciencedirect.com

Join us for this exciting meeting! @embo.org Workshop "Pathogen Immunity and Signalling", 8-12 June, 2026, Leiden, The Netherlands meetings.embo.org/event/26-pat...

Our review "From Histology to High-Resolution Mapping: The Rise of Spatial Omics in Immunology" is now online! onlinelibrary.wiley.com/doi/10.1002/...

From Histology to High‐Resolution Mapping: The Rise of Spatial Omics in ImmunologyImmune regulation is fundamentally spatial, shaped by tissue architecture and local cues. Spatial omics—transcriptomic, proteomic, metabolomic, lipidomic, and phosphoproteomic platforms—preserve coor...onlinelibrary.wiley.com

🧵 (1/2) Interested in tertiary lymphoid structures (TLSs)? Check out our latest review, where we chart how TLSs form across organs and contexts — from lung to liver, CNS, skin, gut & more — and their dual roles in protection vs. pathology.

Tertiary Lymphoid Structures Across Organs: Context, Composition, and Clinical LeversTertiary lymphoid structures (TLSs) arise in non-lymphoid tissues in response to persistent antigen stimulation and chronic inflammation. Spanning organs from lung and liver to meninges, skin, and be....onlinelibrary.wiley.com

Thanks for sharing @brendaraud.bsky.social and @immunologypodcast.com!

Do not miss it! 👇