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Профиль

Diego Ortega-Del Vecchyo

Профиль Vively

Associate professor @liigh-unam.bsky.social. Interested on theoretical population genetics and developing new computational methods to understand our past. He/him/his.

Alessandro and I discussed a paper analyzing a deleterious genetic interaction that causes melanoma in swordtail fishes.

Nature Reviews Cancer

In this #Journal Club, @delvecchyo.bsky.social &Co discuss a study that mapped the genetic basis of hybrid incompatibility in swordtail fish, revealing #melanoma-causing gene interactions that reduce survival in natural hybrid populations. 📖 ⬇️

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Alessandro and I discussed this great paper www.science.org/doi/10.1126/... that investigates a deleterious genetic interaction that causes melanoma.

Natural hybridization reveals incompatible alleles that cause melanoma in swordtail fishA combination of mapping approaches identifies interacting genes that lead to incompatibility and melanoma in natural hybrid fish.www.science.orgNature Reviews Cancer

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Gaceta UNAM cubrió nuestra investigación sobre el impacto de la selección natural en la predicción genética de rasgos complejos en individuos del pasado: www.gaceta.unam.mx/la-seleccion...

La selección natural complica las predicciones genéticas - Gaceta UNAMHacen menos confiables los análisis de características físicas en humanos antiguos, afirma artículo publicado en la revista científica The American Journal of Human Genetics, en el cual participa un g...www.gaceta.unam.mx
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Happy to have worked on this project with @mashaals.bsky.social , Emilia Huerta-Sanchez and Valeria Añorve-Garibay. We analyzed how stabilizing and directional selection cause problems to predict traits in ancient samples.

Mashaal Sohail

Our new work is now out in AJHG "Natural selection acting on complex traits hampers the predictive accuracy of polygenic scores in ancient samples." Great collaboration with @delvecchyo.bsky.social and Emilia Huerta-Sanchez, led by Valeria Añorve-Garibay.

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Don't forget to submit your abstract for "Probabilistic Modeling in Genomics 2025". Deadline: January 10th, 2025. meetings.cshl.edu/meetings.asp...

Probabilistic Modeling in GenomicsCold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.meetings.cshl.edu
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I have received tenure! I got here thanks to the support from my students, colleagues, mentors and home institution ( @liigh-unam.bsky.social ). I plan to continue doing research on Theoretical Population Genetics and developing methods to understand how Evolution has shaped our past.

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Our preprint analyzing the impact of stabilizing and directional selection on the prediction of complex traits in ancient samples is out. Work spearheaded by Valeria Añorve-Garibay in collaboration with Mashaal Sohail and Emilia Huerta-Sánchez. Thread below: www.biorxiv.org/content/10.1...

Natural selection acting on complex traits hampers the predictive accuracy of polygenic scores in ancient samplesbioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institutionwww.biorxiv.org
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Happy to see @Alanizarr, Sebastián Iturbe and Abad Guzmán from our group presenting their work during the poster session. #SMBE2024

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During dinner a lot of people were asking: "Where is the after party?". It is tomorrow at 9am. We have a great set of talks on new approaches to estimate demography and natural selection. Symposium organized with @valenomics #smbe2024

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"Community Engagement Experiences of the Afromexico Genomics Project" by @paleogenomics .

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Our group will have a strong presence at #SMBE2024 . Two students will be giving talks and another three students will be presenting posters.

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The abstract book is available online along with the scientific program and the travel guide to #smbe2024 #smbe24 https://smbe2024.org/ . Happy to see the community in Puerto Vallarta, Mexico soon.

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Don't forget to register for #SMBE2024 https://smbe2024.org/ today in order to be part of the scientific program if you were accepted to give a poster or oral presentation.

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We had a strong presence in the "Días Académicos" event held the last couple of days @LIIGH_UNAM . We had poster presentations by Sebastián Iturbe and Abad Guzmán. @AlanIzarr and @PsyduckResearch gave talks.

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Our perspective piece "The Promise of Inferring the Past Using the Ancestral Recombination Graph (ARG)" is out. Work with Débora YC Brandt, Christian D Huber , Charleston WK Chiang: academic.oup.com/gbe/article/...

The Promise of Inferring the Past Using the Ancestral Recombination GraphAbstract. The ancestral recombination graph (ARG) is a structure that represents the history of coalescent and recombination events connecting a set of sequenceacademic.oup.com
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We, Alan Izarraras Gomez and I, wrote a 'News and Views' on the latest Nakatsuka et al. (2023) paper discovering an ancient migration (around 5,200 years old) from Northwest Mexico to California that likely spread a language family in California: www.nature.com/articles/d41... rdcu.be/drLBe

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