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🧵 GETCampy Stories #3 Campylobacter is the leading cause of bacterial gastroenteritis worldwide. Yet we still don't have a licensed human vaccine, and reducing infections remains surprisingly difficult. Why? 👇 #MicroSky #OneHealth #Campylobacter

New Preprint 🥳 Here we wondered how phages that have been extensively studied in laboratory E. coli strains actually behave when they encounter a real pathogen such as O157:H7 strain...one with a far more complex cell surface & one of the most consequential foodborne pathogens in the United States.

Animated E. coli Bacteria DrawingAlt: Animated E. coli Bacteria Drawingstatic.klipy.com

New Research The spread of sexually transmissible drug-resistant shigellosis in England: a genomic epidemiology study www.thelancet.com/journals/lan...

The spread of sexually transmissible drug-resistant shigellosis in England: a genomic epidemiology studyOur study shows the distinct and intensifying sexual transmission of shigellosis, highlighting the urgent need to address sexually transmissible shigellosis as a distinct health threat. Traditional in...www.thelancet.com

Interested in microbiology, immunology, and host-pathogen interactions? Come work with us! Our department at OHSU is opening a search for a new tenure-track faculty position. See the job advertisement for details. Please share within your networks! www.nature.com/naturecareer...

Faculty Position in Molecular Microbiology and Immunology - Portland, Oregon job with Oregon Health & Science University (OHSU) - Molecular Microbiology and Immunology | 12858852The Department of Molecular Microbiology and Immunology at OHSU invites applications for a tenure-track Assistant or Associate Professor position.www.nature.com

We hope you all had as wonderful a time in Paris last week as we did - please do fill out the EMBO feedback form that was emailed out this morning to help us improve the meeting! #Shigella2026

Russell Vance taking leaps and bounds with the mouse knock out model - happy to share mice and test vaccines #Shigella2026

@christinafaher1.bsky.social talks us through benefits and insights from organoid models, including malnourished organoids!

Cecilia Toro now giving us a tour or Shigella AMR molecular epi in Latin America

@yekwah.bsky.social launches FlexIt: the S. flexneri genotyping scheme at @shigellameeting.bsky.social 🎉

Karen Kotloff follows Philippe’s molecular talk with a tour de force in Shigella clinical and epidemiological features

Keynote #1 is off with Philippe Sansonetti taking us on an incredible tour of Shigella research in the last half century

The CDC warns that extensively drug-resistant (XDR) Shigella is on the rise in US. The prevalence of XDR Shigella isolates in US surveillance data rose from 0% during 2011-2015 to 8.5% in 2023. Read more: ow.ly/VXee50YLphl 📷: CDC, Stephanie Rossow

Passengers watch Artemis II blast off from commercial plane. 🔭 🧪 www.bbc.co.uk/news/videos/...

Passengers watch Artemis II blast off from commercial planePeople on a commercial flight were treated to a rare view of the launch of Nasa's first crewed mission to the Moon in half a century.www.bbc.co.uk

Quick takes: -More sick in the E coli outbreak linked to raw cheese & raw dairy products -Increase in Shigella cases in UK, some drug-resistant -The Global Fund approved funds to support the diagnosis and treatment of tuberculosis in Sudan Read more: ow.ly/gcWG50YzXYe.

Quick takes: More E coli tied to raw cheese, drug-resistant Shigella in UK, TB funds for SudanThe CDC and FDA continue to investigate the E coli outbreak, which has sickened 9 people in 3 states.ow.ly

New paper from my lab! First (as far as we know) comprehensive review of the Shigella outbreak data collected by CDC between 2009 and 2022. This is going to become my favorite class example of the struggle of dealing with state-reported data at a national level

Frontiers | Temporal trends of Shigella outbreaks in the United States, 2009–2022BackgroundShigella infections remain a significant public health threat in the United States because of their diverse outbreak patterns and high disease impa...www.frontiersin.org

Well done @xosematanza.bsky.social and Clements lab! Happy that I was able to contribute to this nice new publication, using TraDIS to gain insights into how Shigella sonnei can survive long-term nutrient starvation. journals.asm.org/doi/10.1128/...

Ever wonder what really goes down in the microscopic battleground of a catheter-associated UTI? 🦠⚔️ Our new review unpacks the Host-Pathogen Interactions during CAUTIs. Thank you, Kurt Kohler and Alyssa La Bella @alabella14.bsky.social for putting this together!!! pubs.acs.org/doi/full/10....

Host Pathogen Interactions during Catheter-Associated Urinary Tract InfectionsAs a leading cause of healthcare-associated infections, catheter-associated urinary tract infections (CAUTIs) present a unique challenge due to the high prevalence of multidrug-resistant and polymicrobial pathogens. Distinct from uncomplicated UTIs, the insertion of a urinary catheter provokes tissue damage that triggers inflammation, plasma extravasation, and the deposition of host fibrinogen. This inflammatory response drives the robust recruitment of immune cells and plasma extravasation, leading to the accumulation of fibrinogen─a key coagulation protein─on the device and bladder epithelium. This fibrinogen-rich environment creates a unique niche for intricate host–pathogen interactions. Crucially, uropathogens exploit these deposits to establish persistent biofilms, while the protein scaffold simultaneously modulates host immunity. Understanding these mechanisms, particularly the role of fibrinogen-binding adhesins, is vital for developing targeted, antimicrobial-sparing therapeutics. In this perspective, we examine the strategies uropathogens employ to persist in the catheterized bladder, the corresponding host immune response, and emerging strategies to prevent CAUTI.pubs.acs.org

A fabulous undergraduate researcher I mentor is graduating this spring and is looking for a job as a lab technician! She's interested in bacterial pathogenesis and is planning to go to grad school after getting more research experience. Please let me know if you or anyone you know is hiring!

Differential targeting of human pyroptotic caspase-5 and caspase-4 by Shigella OspC2 and OspC3 | mBio journals.asm.org/doi/10.1128/...

Differential targeting of human pyroptotic caspase-5 and caspase-4 by Shigella OspC2 and OspC3 | mBioShigella species are human-specific gram-negative pathogens that establish a replicative niche in intestinal epithelial cells by blocking pyroptosis, a key inflammatory cell death pathway. We reveal t...journals.asm.org

We are current investigating Shigella cases linked to travel to Cape Verde. Regular handwashing with soap and water (especially after the toilet, changing nappies, and before handling food) is the best way to prevent the bacteria from spreading.