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Brain (and other tissues’) ultrastructure can be resolved with X-ray nanoimaging techniques. If at @fens.org #FENS2026, come to my poster P60 this morning to find out more! 🧠🔬

#paper: Drying tissue samples enhances contrast in X-ray phase contrast imaging while largely preserving ultrastructure. 🧠🔬 doi.org/10.1107/S160... @safekhan.bsky.social @andreas-t-schaefer.bsky.social @crick.ac.uk @embl.org @imperialcollegeldn.bsky.social @esrf.fr @uclnpp.bsky.social

Here's a spotlight article on our recent study! Tissue ultrastructure can be resolved with X-rays, which impacts not only how we can study neuronal circuits but soft tissues more generally. Kudos to Ana Diaz, @adrianawanner.bsky.social, @andreas-t-schaefer.bsky.social and all authors.

Imaging spotlight: Revealing mouse brain ultrastructure using non-destructive X-ray tomography - FocalPlaneImaging spotlight: Revealing mouse brain ultrastructure using non-destructive X-ray tomography - Newsfocalplane.biologists.com

I was glad to receive a Science Achievement Award from @crick.ac.uk! Thanks!! Cheers to all co-authors of our study showing that tissue ultrastructure can be resolved by X-rays. www.nature.com/articles/s41... And congrats as well to all the other awardees - such a pleasure to be in this lot!

Nondestructive X-ray tomography of brain tissue ultrastructure - Nature MethodsOptimizations of X-ray nanotomography including the choice of resin allows high-resolution imaging of mouse brain tissue, approaching the resolution of volume electron microscopy. Since it does not re...www.nature.com

#paper! X-rays can resolve #ultrastructure in tissues non-destructively. www.nature.com/articles/s41... Shoutout to key collaborators at @crick.ac.uk and @psich.bsky.social Ana Diaz, @adrianawanner.bsky.social and @andreas-t-schaefer.bsky.social, and to the whole team that made this possible.

Check these positions at @crick.ac.uk! It’s an outstanding opportunity to shape the way we can map neuronal circuits - and more broadly biological tissues.

Join us *next Monday*! #CrickXrays25 X-ray #nanoimaging of biological tissues 🇬🇧🌐 @crick.ac.uk & online tinyurl.com/crickxrays25 Sponsored by @dectris.bsky.social, @webknossos.org and @biologists.bsky.social and backed by @brukercorporation.bsky.social and Histomography

#Nanoimaging symposium @crick.ac.uk! At #CrickXrays25 we'll tackle: 💫synchrotron upgrades 📈current limits in throughput, volume, resolution 🧪sample preparation for X-ray PC imaging 🧠♥️applications in neuroscience and tissue life science 🗓️13th October 2025 🇬🇧🌐 London & online tinyurl.com/crickxrays25

Hard X-ray imaging of biological soft tissues symposium 2025tinyurl.com

#preprint: We optimised the preparation of tissues for #X-ray phase contrast imaging. Drying tissue samples (instead of embedding them) brings more signal in #X-ray phase contrast images. The process largely preserves #ultrastructure. @safekhan.bsky.social @andreas-t-schaefer.bsky.social

#preprint: We mapped the structure and function of olfactory bulb circuits with in vivo 2-photon microscopy and synchrotron #Xray holographic nanotomography. doi.org/10.1101/2025... @yuxinzhang.bsky.social @andreas-t-schaefer.bsky.social @apacureanu.bsky.social @crick.ac.uk @esrf.fr

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