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The plasmids I constructed for my paper are now available on Addgene! If anyone feels like reconstructing a synthetic reaction-diffusion circuit in mammalian cells... www.addgene.org/browse/artic... #OpenScience #SharingisCaring

Check out my first preprint highlight with @prelights.bsky.social! How cells read the room - coordinated symmetry breaking and proportional cell fate allocation in neural organoids, from Hannah T Stuart et al. Lovely story with solid back-and-forth between modelling and perturbative experiments.

Minimal essential requirements for neural tube self-organisation - preLightsHow cells read the room - coordinated symmetry breaking and proportional cell fate allocation in neural organoidsprelights.biologists.com

Beautiful, crazy #sciart

«The biases do not disappear; they get encoded into the model and then laundered into outputs that feel objective because they are numerical. Replacing one prestige filter with another that is harder to see or challenge is not progress toward equity in science; it’s the opposite. »

AI’s top 1% preprints «provides little information on why we should read those preprints or how relevant they might be to any individual». AI can be useful to find gaps between data and claims, cluster preprints per topic, or for author support - NOT to replace IF with more biased and opaque metrics

One goal of "understanding-by-building" is to test the sufficiency of established models to generate predicted phenotypes in the messy context of living cells. In my postdoc, I asked whether simple two-component circuits could generate self-organised patterns in mammalian cells. 1/4

Supplemental Movie 1Timelapse microscopy of L929 mouse fibroblasts engineered with a synthetic reaction-diffusion circuit, composed of synNotch-mediated juxtacrine activation and paracrine inhibition (JAPI), showing the ...vimeo.com

Beautiful piece on how field-specific journals with high ethical standards, such as Development, don’t try to « Game » the impact factor system - and practical steps to move away from this inherently flawed metric as a researcher (see Box 2)

www.cell.com/cell-systems... Great review from Pulin Li's lab on synthetic developmental biology - the knowledge gained through bottom-up reconstruction of developmental processes is not just how the embryo works, but also how multicellular systems CAN possibly work to generate form and function.

Discovering what is possible: How synthetic biology illuminates developmentWhile embryos have long served as the foundation of developmental biology, in vitro reconstruction of developmental modules has provided insight into their operational rules and limits. Using three re...www.cell.com

The peer-review system needs an update. Biology Open did a cool experiment - contract reviewers in advance, and compensate them for a job well done. The results: it accelerates the process without loss of quality! Very promising. It’s not like for-profit journals can’t afford it…

I’m super excited to announce that the work from my postdoc is now openly available on BioRxiv!! A novel reaction-diffusion architecture for engineering self-organized patterns in mammalian cells, from @leonardomorsut.bsky.social lab and friends (1/9) www.biorxiv.org/content/10.6...

How are preprints perceived and evaluated in the life sciences from a PI's perspective? Check our my podcast episode through the @asapbio.bsky.social Fellow's program, where I interviewed @leonardomorsut.bsky.social about his perspective on the topic! My key takeaways: 1/6

Why do we do science? This was my opener for a department roundtable “Reimagining Scientific Evaluation: Are we judging a book by its cover?”, inspired by @asapbio.bsky.social’s Fellows program. Now more than ever, we should strive for an academic culture that’s transparent, efficient, and fair. 1/5