⟳ Репост от Geoff Faulkner
Now online! Co-option of retrotransposons promotes antibody diversification
Co-option of retrotransposons promotes antibody diversificationA longstanding mystery in antibody diversification is how AID specifically targets immunoglobulin V genes. Ancient LINE-1 retrotransposons embedded within the immunoglobulin locus provide a recruitment platform for the HUSH complex and AID to drive somatic hypermutation.dlvr.it